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"This book is concerned with the electron transfer between electrodes on one hand and DNA, RNA and proteins on the other hand and with the use of electrochemistry and electrochemical sensors in DNA and protein analyses. Electrochemical bioassays involve newly emerging fields of genomic, proteomics, biomedicine and biotechnology. DNA and protein chips with electrochemical detection represent new tools of science, medicine and other areas of practical life in this century."--BOOK JACKET.
The Physical Basis of Biochemistry is a rigorous, imaginative textbook that applies physical and chemical principles to understanding the bi ology of cells. The book features numerous problem sets and examples, clear illustrations, and extensive appendices that provide additional information on mathematics, physics and chemistry topics that support the text. The Physical Basis of Biochemistry is suitable for graduate and advanced undergraduate courses in physical biochemistry, biophysic al chemistry, and physical chemistry with application in the life scie nces. It will be welcomed by instructors seeking a text which combines a quantitative approach with a consistent biological perspective.
The past half century has seen an extraordinary growth in the fields of cellular and molecular biology. From simple morphologi cal concepts of cells as the essential units of living matter there has been an ever-sharper focus on functional organization of living systems, with emphasis on molecular dynamics. Thus, life forms have come to be defined increasingly in terms of metabolism, growth, reproduction and responses to environmental perturbations. Since these properties occur in varying degrees in systems below the level of cellular organization, there has been a blurring of older models that restricted the concepts of life to cellular systems. At the same time, a search has begun for elemental as pects of molecular and atomic behavior that might better define properties common to all life forms. This search has led to an examination of nonlinear behavior in biological macromolecules, whether in response to electrical or chemical stimulation, for example, or as a means of signaling along a molecular chain, or as a means of energy transfer. Experimental knowledge in this area has grown rapidly in the past decade, and in some respects has outstripped theoretical models adequate to ex plain these new observations. Nevertheless, it can be claimed that there is now an impressive body of experiments implicating non linear, nonequilibrium processes as fundamental steps in sequential operations of biological systems.
Medicine, chemistry, physics and engineering stand poised to benefit within the next few years from the ingenuity of complex biological structures invented and perfected by nature over millions of years. This book provides both researchers and engineers as well as students of all the natural sciences a vivid insight into the world of bioelectronics and nature's own nanotechnological treasure chamber.