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Major neurocognitive disorders are one of the leading causes of disability and dependency among the elderly worldwide. Notably, their far-reaching impact extends beyond the estimated 50 million people currently living with a major neurocognitive disorder. As the conversion to Alzheimer's disease (AD) progresses, patients’ symptoms (e.g., memory loss, severe impairments in thinking and behavior) place a heavy toll on their caregivers, family, and friends, who face emotional frustration, coupled with great financial stress. Furthermore, in terms of global cost estimation, the World Health Organization predicted that by 2030, the treatment of patients with AD and other forms of acquired cognitive impairment will cost the healthcare system US$1.7 trillion (or US$2.8 trillion, if corrected for the increase in care costs).
It has become accepted in the neuroscience community that perception and performance are quintessentially multisensory by nature. Using the full palette of modern brain imaging and neuroscience methods, The Neural Bases of Multisensory Processes details current understanding in the neural bases for these phenomena as studied across species, stages of development, and clinical statuses. Organized thematically into nine sub-sections, the book is a collection of contributions by leading scientists in the field. Chapters build generally from basic to applied, allowing readers to ascertain how fundamental science informs the clinical and applied sciences. Topics discussed include: Anatomy, essential for understanding the neural substrates of multisensory processing Neurophysiological bases and how multisensory stimuli can dramatically change the encoding processes for sensory information Combinatorial principles and modeling, focusing on efforts to gain a better mechanistic handle on multisensory operations and their network dynamics Development and plasticity Clinical manifestations and how perception and action are affected by altered sensory experience Attention and spatial representations The last sections of the book focus on naturalistic multisensory processes in three separate contexts: motion signals, multisensory contributions to the perception and generation of communication signals, and how the perception of flavor is generated. The text provides a solid introduction for newcomers and a strong overview of the current state of the field for experts.
Dementia: Comprehensive Principles and Practice is a clinically-oriented book designed for clinicians, scientists, and other health professionals involved in the diagnosis, management, and investigation of disease states causing dementia. A "who's who" of internationally-recognized experts contribute chapters emphasizing a multidisciplinary approach to understanding dementia. The organization of the book takes an integrative approach by providing three major sections that (1) establish the neuroanatomical and cognitive framework underlying disorders of cognition, (2) provide fundamental as well as cutting-edge material covering specific diseases associated with dementia, and (3) discuss approaches to the diagnosis and treatment of dementing illnesses.
Electroencephalograms (EEGs) are becoming increasingly important measurements of brain activity and they have great potential for the diagnosis and treatment of mental and brain diseases and abnormalities. With appropriate interpretation methods they are emerging as a key methodology to satisfy the increasing global demand for more affordable and effective clinical and healthcare services. Developing and understanding advanced signal processing techniques for the analysis of EEG signals is crucial in the area of biomedical research. This book focuses on these techniques, providing expansive coverage of algorithms and tools from the field of digital signal processing. It discusses their applications to medical data, using graphs and topographic images to show simulation results that assess the efficacy of the methods. Additionally, expect to find: explanations of the significance of EEG signal analysis and processing (with examples) and a useful theoretical and mathematical background for the analysis and processing of EEG signals; an exploration of normal and abnormal EEGs, neurological symptoms and diagnostic information, and representations of the EEGs; reviews of theoretical approaches in EEG modelling, such as restoration, enhancement, segmentation, and the removal of different internal and external artefacts from the EEG and ERP (event-related potential) signals; coverage of major abnormalities such as seizure, and mental illnesses such as dementia, schizophrenia, and Alzheimer’s disease, together with their mathematical interpretations from the EEG and ERP signals and sleep phenomenon; descriptions of nonlinear and adaptive digital signal processing techniques for abnormality detection, source localization and brain-computer interfacing using multi-channel EEG data with emphasis on non-invasive techniques, together with future topics for research in the area of EEG signal processing. The information within EEG Signal Processing has the potential to enhance the clinically-related information within EEG signals, thereby aiding physicians and ultimately providing more cost effective, efficient diagnostic tools. It will be beneficial to psychiatrists, neurophysiologists, engineers, and students or researchers in neurosciences. Undergraduate and postgraduate biomedical engineering students and postgraduate epileptology students will also find it a helpful reference.
Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.
To a certain extent the dementias have been forgotten diseases until just recen tly when they were brought to the attention of the general public and health authorities as a result of the increasing number of cases in the aging popula tion, especially among famous people, and because of the efforts of private foundations. The goals of the present volume are to present the dementias to health prac titioners, to provide some basic information on their epidemiology and biolo gical basis and to discuss the diagnostic and clinical problems that physicians and institutions face when caring for demented patients. This book explores the various types of dementias and is not limited to Alzheimer's disease although, as expected, more information is available and presented on this pathology. On the other hand, a few fundamental questions on dementia can only be answe red through a comparison of the various forms. Examples of such questions are the following: Is the loss of cerebral tissue sufficient to cause dementia? Are there thresholds or is there a continuous progression toward the irreversible development of dementia? Are there common pathways in the dementing pro cess? Are there common risk factors? Comparative analysis allows the common and distinctive patterns of the various dementias to be defined, ultimately lea ding to more focused therapeutic interventions.
Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder
Principles of Geriatric Neurology combines input from both neurologists and geriatricians, offering a superbly focused examination of the neurologic problems of our aging population. The book includes recent research on Alzheimer's disease and other disorders, and discussions addressing normal biologic and neurologic changes that occur with aging, abnormal signs and their related pathophysiology, and improved diagnosis and management of patients with age-related problems.
New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.
Alzheimer's disease and related dementias represent an increasing threat to public health, in addition to the stress they place upon patients, their families and caregivers. While historically the emphasis in studying Alzheimer's disease has been on cognitive decline, this unique, state of the art book rectifies this imbalance and addresses the key behavioral and neuropsychiatric disorders associated with dementing conditions. Written by a world famous leader in the field of dementia and neuropsychiatry, this dynamic text has been richly illustrated with graphs, brain imaging and pathology. Rigorously referenced, it is packed with essential information and will be an excellent resource for clinicians as well as an ideal teaching text.