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The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
Metal- Free Synthetic Organic Dyes is a comprehensive guide to the synthetic, organic dyes that are classified by their chemical structure. As synthetic dyes are playing an increasingly important role in modern life, with applications in both industry and scientific research, this book provides insights on the many research attempts that have been made to explore new photosensitizers in the development of dye sensitized solar cells (DSCs). These novel photosensitizers have incorporated, within their structure, different organic groups, such as coumarins, cyanines, hemicyanines, indolines, triphenylamines, bis(dimethylfluorenyl) aminophenyls, phenothiazines, tetrahydroquinolines, carbazoles, polyenes, fluorenes, and many others. This comprehensive resource contains color figures and schemes for each dye discussed, and is an invaluable resource for organic, inorganic and analytical chemists working in academia and industry. - Features a discussion of the synthesis of the new, high-value synthetic dyes and pigments and their applications and performance - Includes coverage of new photosensitizers and their role in the development of dye sensitized solar cells (DSCs) - Covers synthesis of the functional dyes that are ideal for applications in the dye and pigment industry, textiles, color science, solar energy materials and solar cells, biomedical sensors, advanced materials, structure and synthesis of materials, and more
In this book the authors go back to basics to describe the structural differences between dyes and pigments, their mechanisms of action, properties and applications. They set the scene by explaining the reasons behind these differences and show how dyes are predominately organic compounds that dissolve or react with substrates, whereas pigments are (predominantly) finely ground inorganic substances that are insoluble and therefore have a different mode of coloring. They also describe the role of functional groups and their effect on dyeing ability, contrasting this with the way in which pigments cause surface reflection (or light absorption) depending on their chemical and crystalline structure and relative particle size. The book explores the environmental impact of dyes in a section that covers the physical, chemical, toxicological, and ecological properties of dyes and how these are used to assess their effect on the environment and to estimate whether a given product presents a potential hazard. Lastly, it assesses how, in addition to their traditional uses in the textile, leather, paper, paint and varnish industries, dyes and pigments are indispensable in other fields such as microelectronics, medical diagnostics, and in information recording techniques.
This volume examines the chemistry of natural and synthetic dyes produced for non-textile markets, where much new basic research in color chemistry is now taking place.The first group of chapters covers the design, synthesis, properties and application technology pertaining to dyes for digital printing and photography. The reader will be pleased with the breadth and depth of information presented in each case. Of particular interest is the discussion of strategies for the design of dyes in these categories, with emphasis on enhancing technical properties. In view of certain new developments, the ink-jet chapter includes results from studies pertaining to dyes for textiles.The three chapters comprising Section II of this volume cover the broad subject of dyes for food, drug and cosmetic applications and then provide an in-depth look at dyes for biomedical applications and molecular recognition. The chapter on dyes for molecular recognition places emphasis on applications in the biological sciences, including sensory materials and artificial receptors. While the former two topics have been covered elsewhere in the past, the present chapters are unequalled in scope.Section III provides an in-depth review of the design of laser dyes and dye-based functional materials. In the first of the two chapters, the major principles of laser operation are summarized. This is followed by a discussion of spectroscopic properties, such as activation and deactivation of absorbed light by laser dyes. Approaches to the development of new laser dyes are presented. The second chapter pertains to the synthesis of dicyanopyrazine-based multifunctional dyes. The visible and fluorescence spectra of these dyes in solution and the solid state are correlated with their three-dimensional molecular structures. Molecular stacking behavior and solid state properties of these "multifunctional" dye materials are presented.The final group of chapters pertains to natural dyes and dyes for natural substrates. In recent years, the impression among certain consumers that "natural" is better/safer has generated much interest in the use of natural dyes rather than synthetics. This has led to a few short discussion papers in which the environmental advantages to using natural dyes have been questioned. The initial chapter in this group provides both a historical look at natural dyes and a comprehensive compilation of natural dye structures and their sources. Though natural dyes are of interest as colorants for textiles, selected ones are used primarily in food and cosmetics.Chapter ten provides an update on the author's previous reviews of structure-color-relationships among precursors employed in the coloration of hair. Chemical constitutions characterizing hair dye structures are presented, along with a summary of available precursors and their environmental properties. Similarly, the chapter on leather dyes covers constitutions and nomenclature, in addition to providing interesting perspectives on the origin and use of leather, the dyeing of leather, and key environmental issues.This volume is concluded with another look at colors in nature. In this case, rather than revisiting colors in plant life, an interesting chapter dealing with color in the absence of colorants is presented. Chapter twelve covers basic concepts of color science and illustrates how 3-D assemblies leading to a plethora of colors are handled in nature. It is our hope that this atypical "color chemistry" chapter will invoke ideas that lead to the design of useful colorants.The chapters presented in this volume demonstrate that color chemistry still has much to offer individuals with inquiring minds who are searching for a career path. This work highlights the creativity of today's color chemists and the wide variety of interesting non-textile areas from which a career can be launched.
Vols. for 1911-13 contain the Proceedings of the Helminothological Society of Washington, ISSN 0018-0120, 1st-15th meeting.