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Pharmacokinetics, the study of the movement of chemicals within the body, is a vital tool in assessing the risk of exposure to environmental chemicals. This bookâ€"a collection of papers authored by experts in academia, industry, and governmentâ€"reviews the progress of the risk-assessment process and discusses the role of pharmacokinetic principles in evaluating risk. In addition, the authors discuss software packages used to analyze data and to build models simulating biological phenomena. A summary chapter provides a view of trends in pharmacokinetic modeling and notes some prospective fields of study.
The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies. This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts: Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use for detecting them, offers an outlook on future toxicity testing, and lists specific recommendations for action. Part II: Mixtures explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be reliably assessed. The book describes alternative approaches and considers the option of developing a modified "hazard index" for chemical compounds.
An in-depth look at the changing approaches that environmentalists, governments, and the open market have taken to water through the lens of world history. When we turn on the tap or twist open a tall plastic bottle, we probably don’t give a second thought about where our drinking water comes from. But how it gets from the ground to the glass is far more convoluted than we might think. In this revised edition of Drinking Water, Duke University professor and environmental policy expert James Salzman shows how drinking water highlights the most pressing issues of our time. He adds eye-opening, contemporary examples about our relationship to and consumption of water, and a new chapter about the atrocities that occurred in Flint, Michigan. Provocative, insightful, and engaging, Drinking Water shows just how complex a simple glass of water can be. “A surprising, delightful, fact-filled book.” —Jared Diamond, Pulitzer Prize–winning author of Guns, Germs, and Steel “Instead of buying your next twelve-pack of bottled water, buy this fascinating account of all the people who spent their lives making sure you’d have clean, safe drinking water every time you turned on the tap.” —Bill McKibben, author of Earth: Making a Life on a Tough New Planet “Drinking Water effortlessly guides us through a fascinating world we never consider. Even for people who think they know water, there is a surprise on almost every page.” —Charles Fishman, bestselling author of The Big Thirst and The Wal-Mart Effect “Salzman puts a needed spotlight on an often overlooked but critical social, economic, and political resource.” —Publishers Weekly
This volume describes the methods used in the surveillance of drinking water quality in the light of the special problems of small-community supplies, particularly in developing countries, and outlines the strategies necessary to ensure that surveillance is effective.
Includes information you need to make intelligent decisions about the safety and treatment of your water.
The Drinking Water Book takes a level-headed look at the serious issues surrounding America's drinking water supply. In the completely revised comprehensive guide to making tap and bottled water safer, you'll find unbiased reporting on what's in your water and how to drink safely. Featuring the latest scientific research, Ingram evaluates the different kinds of filters and bottled waters and rates specific products on the market. The Drinking Water Book: · Honestly and thoroughly tackles a subject vital to ongoing environmental, health, and safety concerns · Shows how to avoid bogus safety tests, scams, and unnecessary expenditures · Explains the toxins in our water, how to test for them, and how to get rid of them · Details which toxins aren't regulated by federal and state water standards
In today's chemically dependent society, environmental studies demonstrate that drinking water in developed countries contains numerous industrial chemicals, pesticides, pharmaceuticals and chemicals from water treatment processes. This poses a real threat. As a result of the ever-expanding list of chemical and biochemical products industry, current drinking water standards that serve to preserve our drinking water quality are grossly out of date. Environmental Science of Drinking Water demonstrates why we need to make a fundamental change in our approach toward protecting our drinking water. Factual and circumstantial evidence showing the failure of current drinking water standards to adequately protect human health is presented along with analysis of the extent of pollution in our water resources and drinking water. The authors also present detail of the currently available state-of-the-art technologies which, if fully employed, can move us toward a healthier future.* Addresses the international problems of outdated standards and the overwhelming onslaught of new contaminants. * Includes new monitoring data on non-regulated chemicals in water sources and drinking water.* Includes a summary of different bottled waters as well as consumer water purification technologies.
Having safe drinking water is important to all Americans. The Environmental Protection Agency's decision in the summer of 2001 to delay implementing a new, more stringent standard for the maximum allowable level for arsenic in drinking water generated a great deal of criticism and controversy. Ultimately at issue were newer data on arsenic beyond those that had been examined in a 1999 National Research Council report. EPA asked the National Research Council for an evaluation of the new data available. The committee's analyses and conclusions are presented in Arsenic in Drinking Water: 2001 Update. New epidemiological studies are critically evaluated, as are new experimental data that provide information on how and at what level arsenic in drinking water can lead to cancer. The report's findings are consistent with those of the 1999 report that found high risks of cancer at the previous federal standard of 50 parts per billion. In fact, the new report concludes that men and women who consume water containing 3 parts per billion of arsenic daily have about a 1 in 1,000 increased risk of developing bladder or lung cancer during their lifetime.