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Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
A strange glowing stone picked up on a sea voyage captivates a ship's crew and has a terrible transforming effect on them.
Open Learning Units offer a very flexible approach to the teaching of psychology. They are designed to be more than sufficient for the purposes of A/S and A-Level psychology, and the applied emphasis will appeal to various vocational courses such as those offered by BTEC and also to mature students on Access courses. Their primary use will be in the classroom with a tutor's guidance, but the interactive style makes them equally appropriate for the purposes of self-study. More advanced students might want to use the Units to learn at their own pace, and in all cases, the careful structure of the writing and the extensive use of Examples, Open Questions and Self-Assessment Questions make them ideal revision guides.
If you were an astronaut traveling far out in space and you looked at the earth, what would you see? A small ball in the huge black universe. That’s where these pictures begin. Then they move closer and closer to the earth, each view revealing new details. Until finally . . . See for yourself. In this wordless picture book with stunning cut-paper illustrations, Steve Jenkins masterfully depicts the many levels of the universe, from the farthest reaches of space to the most familiar corner of your backyard.
Who's having a lucky day is in this clever, hilarious trickster tale? When a delicious-looking piglet knocks on Mr. Fox's door "accidentally," the fox can hardly believe his good luck. It's not every day that dinner just shows up on your doorstep. It must be his lucky day! Or is it? Before Mr. Fox can say grace, the piglet has manipulated him into giving him a fabulously tasty meal, the full spa treatment (with bath and massage), and . . . freedom. In a funny trickster tale of her own, Kasza keeps readers guessing until the surprise ending when they'll realize it was piglet's lucky day all along.
The mid-level text of Flemming's successful series, Reading for Results hones students' comprehension skills and introduces them to the basics of critical reading. Featuring the author's trademark high-interest reading selections--including multi-paragraph readings to prepare students for college-level texts--this developmental text motivates students to complete numerous exercises and tests, while simultaneously fostering the idea that reading is a stimulating and exciting activity in its own right.
This volume contains a collection of essays and discussions which serve as an introduction and guide to current research in the area of drawing inferences from self-selected samples. This topic is of direct interest to a professional audience of survey researchers, pollsters, market researchers, policymakers, statisticians, demographers, economists, and sociologists. The essays themselves and their associated critical discussions are clear and careful; the contributors are among the foremost experts in the field.
A funny, playful salute to the power and importance of books from New York Times best-selling author Carmen Agra Deedy. When Sunrise Elementary School advertised for a thick-skinned librarian with a burning love of books, Miss Lotta Scales knew she was perfect for the job. Who could guard books better than a REAL dragon? Yet when she won't let any of the children take a book from the shelves, the teachers form a delegation. Not even sweet Miss Lemon can convince Miss Lotta Scales that "the library belongs to the children." Fortunately, when nearsighted Molly Brickmeyer stumbles onto a copy of Snuff the Magic Dragon and reads the tale out loud, her storytelling beckons the children back to the library and brings them face to face with the Library Dragon. Can an open book temper the flames of the school's hotheaded librarian? Filled with clever dragon puns, this is an entertaining story, now available in an audio edition, about the power and importance of books for both children and adults.