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In 1961, twenty-eight-year-old Dr. Judah Folkman saw something while doing medical research in a United States navy lab that gave him the first glimmering of a wild, inspired hunch. What if cancerous tumors, in order to expand, needed to trigger the growth of new blood vessels to feed themselves? And if that was true, what if a way could be found to stop that growth? Could cancers be starved to death? Dr. Folkman had ample reason to be self confident — second in his class at Harvard Medical School, he was already considered one of the most promising doctors of his generation. But even he never guessed that his idea would eventually grow into a multibillion-dollar industry that is now racing through human trials with drugs that show unparalleled promise of being able to control cancer, as well as other deadly diseases. For the creation of this book, Dr. Judah Folkman cooperated fully and exclusively with acclaimed science writer Robert Cooke. He granted Cooke unlimited interviews, showed him diaries and personal papers, and threw open the doors of his lab. The result is an astonishingly rich and candid chronicle of one of the most significant medical discoveries of our time and of the man whose vision and persistence almost single-handedly has made it possible. Dr. Folkman's radical new way of thinking about cancer was once considered preposterous. So little was known about how cancer spreads and how blood vessels grow that he wasn't even taken seriously enough to be considered a heretic. Other doctors shook their heads at the waste of a great mind, and ambitious young medical researchers were told that accepting a position in Folkman's lab would be the death of their careers. Now, though, the overwhelming majority of experts believes that the day will soon come when antiangiogenesis therapy supplants the current more toxic and less-effective treatments — chemotherapy, radiation, and surgery-as the preferred method of treatment for cancer in patients around the world, and Dr. Folkman's breakthrough will come to be taken for granted the way we now take for granted the polio vaccine and antibiotics. Dr. Folkman's War brilliantly describes how high the odds are against success in medical research, how vicious the competition for grants, how entrenched the skepticism about any genuinely original thinking, how polluted by politics and commerce the process of getting medicine into patients' hands. But it also depicts with rare power how exalted a calling medicine can be and how for the rare few—the brilliant, the tireless, and the lucky — the results of success can be world-changing. From the Hardcover edition.
This electrifying, intimate account is the exclusive inside story of cancer pioneer Judah Folkman's 35-year pursuit of an idea that is revolutionizing the way cancer is treated around the world.
In 1961, twenty-eight-year-old Dr. Judah Folkman saw something while doing medical research in a United States navy lab that gave him the first glimmering of a wild, inspired hunch. What if cancerous tumors, in order to expand, needed to trigger the growth of new blood vessels to feed themselves? And if that was true, what if a way could be found to stop that growth? Could cancers be starved to death? Dr. Folkman had ample reason to be self confident second in his class at Harvard Medical School, he was already considered one of the most promising doctors of his generation. But even he never guessed that his idea would eventually grow into a multibillion-dollar industry that is now racing through human trials with drugs that show unparalleled promise of being able to control cancer, as well as other deadly diseases. For the creation of this book, Dr. Judah Folkman cooperated fully and exclusively with acclaimed science writer Robert Cooke. He granted Cooke unlimited interviews, showed him diaries and personal papers, and threw open the doors of his lab. The result is an astonishingly rich and candid chronicle of one of the most significant medical discoveries of our time and of the man whose vision and persistence almost single-handedly has made it possible. Dr. Folkman's radical new way of thinking about cancer was once considered preposterous. So little was known about how cancer spreads and how blood vessels grow that he wasn't even taken seriously enough to be considered a heretic. Other doctors shook their heads at the waste of a great mind, and ambitious young medical researchers were told that accepting a position in Folkman's lab would be the death of their careers. Now, though, the overwhelming majority of experts believes that the day will soon come when antiangiogenesis therapy supplants the current more toxic and less-effective treatments chemotherapy, radiation, and surgery-as the preferred method of treatment for cancer in patients around the world, and Dr. Folkman's breakthrough will come to be taken for granted the way we now take for granted the polio vaccine and antibiotics. Dr. Folkman's War brilliantly describes how high the odds are against success in medical research, how vicious the competition for grants, how entrenched the skepticism about any genuinely original thinking, how polluted by politics and commerce the process of getting medicine into patients' hands. But it also depicts with rare power how exalted a calling medicine can be and how for the rare fewthe brilliant, the tireless, and the lucky the results of success can be world-changing. From the Hardcover edition.
Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.
In 1998, Nobel laureate Dr James Watson, co-discoverer of the structure of DNA, said that, in time, Doctor Judah Folkman would be considered the twentieth century's Darwin for his pioneering research into a cure for cancer. However, at that time, although medicines emerging from Folkman's library were curing many forms of cancer, completely and without side effects, success was only seen in mice. Doing the same in humans seemed a long time away.Now that time seems near. Dr Folkman's theory of anti-angiogenesis - that cancer cells can be starved by cutting off their blood supply - has gone into fast-track clinical trials. The new agents rank among the most important new weapons in the war against cancer to emerge in our time. Already, scores of patients thought doomed have had their cancers cured.Doctor Folkman's War is the chronicle of an epoch-making scientific achievement and the story of a man who turned his back on a golden career in surgery to embark on a lonely and lifelong pursuit of a challenging idea. It was an idea roundly ridiculed and dismissed as ludicrous, but it could turn the tide against cancer and have an impact on several dozen other stubborn ailments - soon. Science journalist Robert Cooke is the only writer who has been given complete and exclusive access to Judah Folkman and his staff, and he is also following patients taking part in clinical trials.
Having breast cancer can be devastating for the woman affected - and for her family and loved ones. It can also be confusing, because there are many variations of the disease and at least as many treatments. By bringing together comprehensive information on the subject, Breast Cancer Basics and Beyond helps women better understand their illness and participate in making decisions about all aspects of their treatment and care. In this book, award-winning medical writer Delthia Ricks tells you all about: common and rare types of breast cancer, their causes and symptoms, diagnosis, including mammography and different kinds of biopsies, treatment options, including lumpectomy, mastectomy, chemotherapy, radiation and hormone therapy, benefits and side effects of the most commonly used drugs, your risk factors, including ethnicity, genetics, hormones and diet, life after cancer, follow-up care and dealing with recurrence, reasons for hope: breast cancer research and treatments in development.
In Saving Sight, Dr. Andrew Lam explains the intricacies of human sight and shines a light on the heroes who fought to save it, while also revealing the personal side of life as an eye surgeon - the stress and joy of a man who, on his best days, can turn darkness into light. Many remarkable life stories illuminate this autobiographical/biographical/historical work. Included are Louis Braille, Judah Folkman, Harold Ridley and many others who have enabled us to see in all kinds of unimaginable ways.
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
The author helps readers figure out which leaders matter, why, and when - and what lessons they can learn from those who do matter. Leaders from politics and business are profiled, they include: Abraham Lincoln, Neville Chamberlain, Woodrow Wilson, Thomas Jefferson, Winston Churchill, Jamie Dimon, Al Dunlap, Sir Jacky Fisher, and Judah Folkman.
The American Psychological Association offers this book to help researchers understand ethical conflicts. The examples and analyses help researchers in identifying conflicts of interest and solving ethical dilemmas, planning research, recruiting participants, training researchers, managing matters of informed consent and confidentiality, dealing with intellectual property issues, working with special populations, and updating protocols for institutional review boards.