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The development of European thought as we know it from the dawn of history down to the Dark Ages is marked by the successive secularization and de-secularization of knowledge. From the beginning Greek secular science can be seen painfully disengaging itself from superstition. For some centuries it succeeded in maintaining its separate existence and made wonderful advances; then it was obliged to give way before a new and stronger set of superstitions which may be roughly called Oriental. In the following centuries all those branches of thought which had separated themselves from superstition again returned completely to its cover; knowledge was completely de-secularized, the final influence in this process being the victory of Neoplatonized Christianity. The sciences disappeared as living realities, their names and a few lifeless and scattered fragments being all that remained. They did not reappear as realities until the medieval period ended. This process of de-secularization was marked by two leading characteristics; on the one hand, by the loss of that contact with physical reality through systematic observation which alone had given life to Greek natural science, and on the other, by a concentration of attention upon what were believed to be the superior realities of the spiritual world. The consideration of these latter became so intense, so detailed and systematic, that there was little energy left among thinking men for anything else.
Semmelweis's exposure to the childbed fever was concurrent with his appointment to the Vienna maternity hospital in 1846. Like many similar hospitals and clinics in the major cities of nineteenth-century Europe and America, where death rates from the illness sometimes climbed as high as 40 percent of admitted patients, the Viennese wards were ravaged by the fever. Intensely troubled by the tragic and baffling loss of so many young mothers, Semmelweis sought answers. The Etiology was testimony to his success. Based on overwhelming personal evidence, it constituted a classic description of a disease, its causes, and its prevention. It also allowed a necessary response to the obstetrician's already vocal, rabid, and perhaps predictable critics. For Semmelweis's central thesis was a startling one - the fever, he correctly surmised, was caused not by epidemic or endemic influences but by unsterilized and thus often contaminated hands of the attending physicians themselves.