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In the early nineteenth century the major economic players of the Atlantic trade lanes -- the United States, Brazil, and Cuba -- witnessed explosive commercial growth. Commodities like cotton, coffee, and sugar contributed to the fantastic wealth of an elite few and the enslavement of many. As a result of an increased population and concurrent economic expansion, the United States widened its trade relationship with Cuba and Brazil, importing half of Brazil's coffee exports and 82 percent of Cuba's total exports by 1877. Disease, Resistance, and Lies examines the impact of these burgeoning markets on the Atlantic slave trade between these countries from 1808 -- when the U.S. government outlawed American involvement in the slave trade to Cuba and Brazil -- to 1867, when slave traffic to Cuba ceased. In his comparative study, Dale Graden engages several important historiographic debates, including the extent to which U.S. merchants and capital facilitated the slave trade to Brazil and Cuba, the role of infectious disease in ending the trade to those countries, and the effect of slave revolts in helping to bring the transatlantic slave trade to an end. Graden situates the transatlantic slave trade within the expanding and rapidly changing international economy of the first half of the nineteenth century, offering a fresh analysis of the "Southern Triangle Trade" that linked Cuba, Brazil, and Africa. Disease, Resistance, and Lies challenges more conservative interpretations of the waning decades of the transatlantic slave trade by arguing that the threats of infectious disease and slave resistance both influenced policymakers to suppress slave traffic to Brazil and Cuba and also made American merchants increasingly unwilling to risk their capital in the transport of slaves.
Disease resistance is one of the major factors that can be improved to sustain yield potential in cultivated crops. This book looks at disease resistance in wheat, concentrating on all the economically important diseases -- their economic impact and geographical spread, breeding for resistance, pathogen variability, resistance mechanisms and recent advances made on resistance genes. Newer strategies for identifying resistance genes and identify resistance mechanisms are discussed, including cloning, gene transfer and the use of genetically modified plants.
This book describes the experimental and analytical methodologies available for the genetical analysis of qualitative, quasi-quantitative and quantitative traits and its applications in practical plant breeding and evolution. Models for studying quantitative genetic variation following Birmingham and Edinburgh notations are described. The statistics used is simple and systematic so that the reader will have no difficulty in solving problems in plant genetics. It describes the genetic principles and provides breeding procedures underlying various breeding methods for manipulating qualitative, quasi-quantitative and quantitative traits. It takes into account the latest developments in breeding methodologies including dihaiploidy and apomixis, applications of tissue culture for plant breeding use, genetic engineering for production of transgenics and hybrids, and molecular marker technologies in the analysis of quantitative trait loci, marker assisted selection, evolution and conservation of genetic resources. This book will be useful for undergraduates, postgraduates, teachers and researchers working in the field of genetics and plant breeding.
Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant - Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance - Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance - Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria
Examine the most recent developments in molecular plant pathology! This comprehensive reference book describes the molecular biology of plant-pathogen interactions in depth. With Dr. Vidhyasekaran’s keen insights and experienced critical viewpoint, Bacterial Disease Resistance in Plants: Molecular Biology and Biotechnological Applications not only presents reviews of current research but goes on to suggest future research strategies to exploit the studies in interventions with biotechnological, commercial, and field applications. This extraordinarily well-referenced book delivers in-depth examinations of: the molecular recognition process between plants and bacterial pathogens bacterial genes involved in the recognition process hrp, avr, dsp, and hsv genes the transcription of bacterial genes in plants signal transduction systems in bacteria and plants the functions of resistance genes and defense genes at the molecular level the elicitor molecules of bacterial pathogens and plants and their interactions plant and bacterial cell wall modifications and their role in triggering host defense mechanisms Bacterial Disease Resistance in Plants also explores active oxygen species, inducible plant proteins and their signals and transcription mechanisms, inducible secondary metabolites, and more. It introduces novel strategies for bacterial disease management using genes from human beings, birds, crabs, insects, fungi, bacteria, and bacteriophages; and genetic engineering techniques that can be used to develop transgenic, disease-resistant plants. Generously illustrated with figures and tables that make the data more quickly understandable, Bacterial Disease Resistance in Plants will be an invaluable resource and textbook for plant pathologists, bacteriologists, botanists, plant physiologists, plant molecular biologists, microbiologists, biochemists, plant cell and applied biologists, genetic engineers, and graduate-level students in these disciplines.
Drug-resistant bacteria — known as superbugs — are one of the biggest medical threats of our time. Here, a doctor, researcher, and ethics professor tells the exhilarating story of his race to beat them and save countless lives. When doctor Matt McCarthy first meets Jackson, a mechanic from Queens, it is in the ER, where he has come for treatment for an infected gunshot wound. Usually, antibiotics would be prescribed, but Jackson’s infection is one of a growing number of superbugs, bacteria that have built up resistance to known drugs. He only has one option, and if that doesn’t work he may lose his leg or even his life. On the same day, McCarthy and his mentor Tom Walsh begin work on a groundbreaking clinical trial for a new antibiotic they believe will eradicate certain kinds of superbugs and demonstrate to Big Pharma that investment in these drugs can save millions of lives and prove financially viable. But there are countless hoops to jump through before they can begin administering the drug to patients, and for people like Jackson time is in short supply. Superbugs is a compelling tale of medical ingenuity. From the muddy trenches of the First World War, where Alexander Fleming searched for a cure for soldiers with infected wounds, to breakthroughs in antibiotics and antifungals today that could revolutionise how infections are treated, McCarthy takes the reader on a roller-coaster ride through the history — and future — of medicine. Along the way, we meet patients like Remy, a teenage girl with a dangerous and rare infection; Donny, a retired firefighter with a compromised immune system; and Bill, the author’s own father-in-law, who contracts a deadly staph infection. And we learn about the ethics of medical research: why potentially life-saving treatments are often delayed for years to protect patients from exploitation. Can McCarthy get his trial approved and underway in time to save the lives of his countless patients infected with deadly bacteria, who have otherwise lost all hope?
Applied Plant Biotechnology for Improvement of Resistance to Biotic Stress applies biotechnology insights that seek to improve plant genomes, thus helping them achieve higher resistance and optimal hormone signaling to increase crop yield. The book provides an analysis of the current state-of-the-art in plant biotechnology as applied to improving resistance to biotic stress. In recent years, significant progress has been made towards understanding the interplay between plants and their hosts, particularly the role of plant immunity in regulating, attenuating or neutralizing invading pathogens. As a result, there is a great need to integrate these insights with methods from biotechnology. - Applies biotechnology insights towards improving plant genomes, achieving higher resistance and optimizing hormone signaling to increase crop yield - Presents the most modern techniques, investigations, diagnostic tools and assays to monitor and detect contaminating agents in crops, such as grape, tomato, coffee and stone fruit - Provides encyclopedic coverage of genes, proteins, interaction networks and mechanisms by which plants and hosts seek survival - Discusses the methods available to make crops resistant and tolerant to disease without decreased yield or food production - Provides insights for policymakers into the difficulties faced by scientific researchers in the use of biotechnology intervention, transgenes and genetically modified sequences