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With cardiovascular disease becoming the most common cause of death in people with diabetes, interest in the assessment and treatment of heart disease in these patients has been reawakened. This book examines developing topics from a largely cardiological perspective, covering both pharmacological and non-pharmacological interventions. The DIGAMI study on the use of intravenous insulin infusion at the time of myocardial infarction (MI) has stimulated a large number of discussion papers on the best treatment of MI in the diabetic patient. The UKPDS has shown that treatment of Type 2 diabetes does not reduce cardiovascular end-points significantly, but that aggressive treatment of blood pressure can do so. In addition, sub-group analysis from several large cardiovascular trials has shown that treatment with statins, anti-platelet therapy, ACE inhibitors and other drugs will also reduce cardiovascular events in people with diabetes.
Cardiodiabetes refers to heart disease that develops in people who have diabetes. Compared with people who don't have diabetes, people who have diabetes are at higher risk of heart disease, have additional causes of heart disease, may develop heart disease at a younger age, and may have more severe heart disease. With nearly 1000 pages, this manual is a complete guide to the diagnosis and management of cardiodiabetes. Divided into nine sections, each chapter addresses a separate and distinct issue of clinical relevance. The book provides an insight into clinical spectrum, diagnostic methodology, management strategies, nutraceutical and obesity care, arrhythmia management, coronary intervention, cardiac surgery, rehabilitation, and future directions in cardiodiabetes care. Additionally, the text features discussion on strategies to reduce the growing prevalence of diabetes, and the current pathophysiological understanding of cardiovascular comorbidities in patients with diabetes. More than 500 clinical photographs, illustrations, tables and boxes further enhance the comprehensive text. Key points Nearly 1000 pages providing in depth discussion on diagnosis and management of cardiodiabetes Each chapter addresses a separate issue of clinical relevance Includes future directions in cardiodiabetes care Highly illustrated with more than 500 images, tables and boxes
Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.
The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.
The prevalence of obesity, metabolic syndrome and diabetes - three links of the same 'atherothrombotic chain' - has reached pandemic proportions worldwide. As a result, our civilization is at war against a threatening enemy: cardio-diabetes. Several independent physiological processes underlie the clustering of cardio-diabetes, including central obesity, insulin resistance, dyslipidemia, inflammation, impaired glucose tolerance, and hypertension. Early detection is of overwhelming importance for public health. The complex and intimate relationship between cardiovascular disease and diabetes from basic science to clinical and therapeutic concerns is discussed in this outstanding book. Beginning with molecular, biochemical, inflammatory and cellular aspects, this publication continues with histological and pathophysiological issues, details particular problems in specific metabolic and clinical settings, and finally analyzes several aspects of clinical pharmacology focusing on the optimal management of combined dyslipidemia and non-insulin antidiabetic therapy in cardiac diabetic patients. This book will be a gain in knowledge for every cardiologist, diabetologist, specialist in internal medicine, nutritionalist, general physician and medical student.
This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors and available drug therapies. Appropriate myocardial revascularization strategies are explained and the current state of knowledge is documented regarding target-led multifactorial treatment and the management of acute coronary syndromes, heart failure, and cerebrovascular disease. New algorithms for diagnosis and treatment are presented and to ensure ease of reference each chapter includes a box with practical recommendations as well as informative color illustrations and tables. The handbook will be of value for all cardiologists and diabetologists and will be especially helpful for young cardiologists, who are ever more frequently confronted by patients with diabetes and cardiovascular disease.
Diabetes and Cardiovascular Disease: Evaluation, Prevention & Management presents the epidemiologic relation of diabetes and associated risk factors with cardiovascular disease. This concise guide demonstrates the role of non-invasive imaging strategies for evaluation of cardiovascular disease risk in diabetes, and the role of nutrition and physical activity in preventing diabetes and its cardiovascular complications. Diabetes and Cardiovascular Disease: Evaluation, Prevention & Management also covers the relation of chronic kidney disease to diabetes and cardiovascular consequences, and offers glycaemic control strategies for reducing the risk of cardiovascular disease with diabetes. The wide scope of this book makes it an essential resource for diabetologists, cardiologists and physicians. Key Features Presents the relationship between diabetes and cardiovascular disease Focus on prevention and management, including chapter on quality of care and provider/medical systems in diabetes management Edited by team of experts in the field from the University of California
This issue of Cardiology Clinics, guest edited by Drs. Silvi Shah and Charuhas V. Thakar, will focus on Diabetes/Kidney/Heart Disease. Topics include, but are not limited to, Cardiorenal syndrome-Pathophysiology; Cardiorenal syndrome- treatment; Hypertensive Emergencies; Contrast induced acute kidney injury; Acute Kidney Injury, Heart failure, and health outcomes; Hypertension management in CKD/ESRD/DM; Arrhythmias/ICD/LVAD, Afib, and dialysis; Apol1 and blood pressure changes/hypertension; Novel ant-diabetic therapies and CV reduction; and Hypertensive disorders of pregnancy.
This state-of-the-art reference details current and effective symptom-specific strategies for the diagnosis and management of diabetic patients-emphasizing the exploration of therapeutic options available for the treatment of accelerated coronary complications associated with diabetes. Addresses the pathophysiology underlying advanced heart