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"It is my hope," writes the author in his preface, "that the material collected in this monograph will provide a new perspective in some areas for those students, biologists, and physicians interested in the kidney but too involved with their special trees to notice some of the changes occurring in the forest in which they toil." In the first up-to-date compendium to correlate the changes in kidney structure and function from the onset of organogenesis to the end of childhood growth, Dr. Wallace McCrory presents a new aspect of developmental pediatrics, skillfully explains the clinical enigmas surrounding the immature kidney, and suggests possible research areas for productive exploration. Clearly documented with tables and illustrations, the study synthesizes relevant new knowledge from the fields of embryology, biochemistry, and renal and growth physiology as a means of stimulating reappraisals of the current concepts of the pathophysiology of many childhood renal diseases. Included are reproductions of reconstructed micro dissections of the early stages in the developing human kidney taken from Dr. Jean Oliver's monograph Nephrons and Kidneys.
Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
The traditional approach to kidney disorders is changing. In the field of diagnostics much innovative research is ongoing: from the “old” embryology, revisited and re-interpreted with new eyes in the light of immunohistochemistry, up to metabolomics the latest “daughter” of genomics, the most promising and remarkable of the “omics” disciplines. Between these two extremes we find a universe of novelties, ranging from the most recent urinary biomarkers to the questions of nutrition and growth, as well as those of ethics, which the new populations of extremely low birth weight (ELBW) neonates present to neonatologists and nephrologists. The studies on perinatal programming expands the temporal horizon of precocious reduction in the number of nephrons, both congenital and/or acquired, thus dilating and multiplying the immediate and long-term negative effects. Neonatal asphyxia, obstructive uropathies, nephrotoxic drugs administered to the mother and/or to the neonate, malnutrition, underfeeding, or overfeeding make it necessary to apply all possible preventive measures to ensure the well-being of the kidney. Because of the kidney’s holistic dimension, themethodical and rigorous study of neonatal nephrology has advanced all aspects of health through the life cycle. This volume is an update state of the art of the latest discoveries in neonatal and pediatric nephrology. These advances will have an even greater impact when the same children reach adulthood, and the ultimate consequences of perinatal care are unmasked.
Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.
This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life and the correlation with renal carcinogenesis. Written by well recognized experts in their fields, Kidney Development in Renal Pathology is a valuable tool for pathologists, neonatologists, nephrologists, gynecologists and researchers with an interest in kidney diseases.
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
The Proceedings of the Fifth International Pediatric Nephrology Symposia are dedicated to those who make the writing possible: the delegates; those who wanted to attend, but could not, and to our colleagues, families and friends who helped organize the meeting. with the advent of certification of pediatric nephrologists in the USA and the increasing numbers of pediatric nephrologists contributing to and practic ing this specialty throughout the world, it is appropriate that we begin to record our international symposia in order to periodically document the State of the Art of pediatric nephrology and to share new information in a timely fashion with colleagues who care for children. Four previous international pediatric nephrology symposia have been spon sored by the International Pediatric Nephrology Association. These meetings were held in Guadalajara, Mexico, 1968, Paris, France, 1971, Washington, DC, USA, 1974 and Helsinki, Finalnd, 1977. This is the first time that it has been possible to organize the publication of the proceedings of a symposium. The enclosed manuscripts represent more than seventy percent of the symposia presentations delivered at the Fifth International Pediatric Symposia (October 6-10, 1980, Phila., PAl which was - hosted by St. Christopher's Hospital for Children and The Children's Hospital of Philadelphia representing the Departments of Pediatrics of Temple University School of Medicine and The University of Pennsylvania School of Medicine.
The third edition of a bestseller, this book provides insight from a wide array of international contributors in the field of pediatric nephrology. Copiously illustrated with photomicrographs and clinical diagrams, the third edition reflects current advances in the field. Each chapter contains a set of questions, directed at helping fellows succeed at the American Pediatric Nephrology Board examination. New information for this edition includes changes in treatment options for hyponatremia, and updates on hyperparathyroidism and transplantation. Text boxes highlight important "take home points" throughout the chapters. Clinical Pediatric Nephrology, Third Edition will be a valuable reference for clinicians in nephrology, pediatrics and urology, and any professional involved in the care of children with renal diseases seeking a reliable contemporary text.