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"A subject collection from Cold Spring Harbor perspectives in biology."
This book vividly describes how complex and integrated movements can arise from the properties and behaviors of biological molecules. It provides a uniquely integrated account in which the latest findings from biophysics and molecular biology are put into the context of living cells. This second edition is updated throughout with recent advances in the field and has a completely revised and redrawn art program. The text is suitable for advanced undergraduates, graduate students, and for professionals wishing for an overview of this field.
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Winner, 2010 PROSE Award for Excellence in the Biological Sciences. Professional and Scholarly Publishing division of the Association of American Publishers In this unique book, Peter S. Ungar tells the story of mammalian teeth from their origin through their evolution to their current diversity. Mammal Teeth traces the evolutionary history of teeth, beginning with the very first mineralized vertebrate structures half a billion years ago. Ungar describes how the simple conical tooth of early vertebrates became the molars, incisors, and other forms we see in mammals today. Evolutionary adaptations changed pointy teeth into flatter ones, with specialized shapes designed to complement the corresponding jaw. Ungar explains tooth structure and function in the context of nutritional needs. The myriad tooth shapes produced by evolution offer different solutions to the fundamental problem of how to squeeze as many nutrients as possible out of foods. The book also highlights Ungar's own path-breaking studies that show how microwear analysis can help us understand ancient diets. The final part of the book provides an in-depth examination of mammalian teeth today, surveying all orders in the class, family by family. Ungar describes some of the more bizarre teeth, such as tusks, and the mammal diversity that accompanies these morphological wonders. Mammal Teeth captures the evolution of mammals, including humans, through the prism of dental change. Synthesizing decades of research, Ungar reveals the interconnections among mammal diet, dentition, and evolution. His book is a must-read for paleontologists, mammalogists, and anthropologists.
Using familiar examples and clear arguments, this volume offers fresh alternatives to widespread misconceptions about biological development.
Humans are mammals. Most of us appreciate that at some level. But what does it mean for us to have more in common with a horse and an elephant than we do with a parrot, snake or frog? After a misdirected football left new father Liam Drew clutching a uniquely mammalian part of his anatomy, he decided to find out more. Considering himself as a mammal first and a human second, Liam delves into ancient biological history to understand what it means to be mammalian. In his humorous and engaging style, Liam explores the different characteristics that distinguish mammals from other types of animals. He charts the evolution of milk, warm blood and burgeoning brains, and examines the emergence of sophisticated teeth, exquisite ears, and elaborate reproductive biology, plus a host of other mammalian innovations. Entwined are tales of zoological peculiarities and reflections on how being a mammal has shaped the author's life. I, Mammal is a history of mammals and their ancestors and of how science came to grasp mammalian evolution. And in celebrating our mammalian-ness, Liam Drew binds us a little more tightly to the five and a half thousand other species of mammal on this planet and reveals the deep roots of many traits humans hold dear.
There are nearly 6,000 mammalian species, among them our own. Research on our evolutionary cousins has a long history, but the last 20 years have seen particularly rapid progress in disentangling the interrelationships and evolutionary history of mammals. The present volume combines up-to-date reviews on mammalian phylogenetics with paleontological, taxonomic and evolutionary chapters and also summarizes the historical development of our insights in mammalian relationships, and thus our own place in the Tree of Life. Our book places the present biodiversity crisis in context, with one in four mammal species threatened by extinction, and reviews the distribution and conservation of mammalian diversity across the globe. This volume is the introductory tome to the new Mammalia series of the Handbook of Zoology and will be essential reading for mammalogists, zoologists and conservationists alike.
Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References
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