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Sir Richard Doll, FRS, FRCP ICRF Cancer Research Studies Unit Radcliffe Infirmary, Oxford, UK The twentieth century has seen few changes more remarkable than the improvement in health that has occurred nearly everywhere, most spectacularly in the economically developed countries. In these countries improved nutrition, better housing, the control ofinfection, smaller family sizes, and higher standards of education have brought about a situation in which more than 97% of all liveborn children can expect to survive the first half ofthe three score years and ten that formerly was regarded as the allotted span oflife. From then on, however, the position is less satisfactory. Some improvement has occurred; but the proportion of survivors who die prematurely, that is under 70 years of age, varies from 25% to over 50% in men and from 13% to 28% in women, the extremes in both sexes being recorded, respectively, in Japan and Hungary. Most of these deaths under 70 years of age must now be called premature, even in Japan. For most of them are not the result of any inevitable aging process, but instead are the consequences of diseases (or types of trauma) that have lower-often much lower-age-specific incidence rates in many of the least developed countries.
In this major synthesis of cross-cultural research, 34 distinguished scientists study 25 common metabolic and degenerative diseases characteristic of all advanced Western nations and then examine their incidence in developing countries, among both hunter-gatherers and peasant agriculturalists. Thus the authors provide a unique opportunity to compare epidemiological data reflecting modern modes of life with data influenced by habits and diets dating back 400 generations to the advent of agriculture, and even 200,000 generations or more to the dawn of man. The results confirm the view that diseases like hypertension, lung cancer, diverticular disease, and appendicitis are maladaptations to environmental factors introduced since the Industrial Revolution. They also demonstrate that such diseases become more prevalent when Western lifestyles are adopted in primitive societies. Certain studies reveal a regression of disease incidence when exercise is increased and a diet high in starch and fiber, low in fat and salt, is resumed--characteristics of a simpler way of life. Western Diseases greatly broadens our perspective on some of the most vexing health problems in our society. It will be an essential reference for epidemiologists, nutritionists, and gastroenterologists in particular.
This is the story of the discovery of the first human cancer virus. Through intriguing accounts that include some remarkable characters and individual stories from around the globe - including the UK, Africa, USA, and China - it tells the story of the Epstein-Barr virus and the understanding of its connections to a variety of other diseases.
This biography of Dr. Denis Parsons Burkitt, after whom the childhood cancer Burkitt's lymphoma was named, and who was a pioneer of the dietary fiber movement, paints a personal but holistic portrait of both the man and his life's work. Featuring excerpts from Dr. Burkitt's personal diaries, spanning seven decades from his boyhood to just before his passing, and extensive family archives, this book invites readers to follow Burkitt's journey through life and experience his tribulations and successes. Prof. John Cummings was a colleague of Dr. Burkitt and weaves the tale of his life through the lens of family, faith, and science. The journey takes Burkitt from his childhood in Ireland, a country undergoing major social upheaval, through his medical studies in Dublin, to army service in Africa in the midst of WWII and the independence movements that swept the continent in the following years. During his two decades spent in Uganda, working for the Colonial Medical Service, Burkitt made his first major contribution to cancer research - the characterization of Burkitt's lymphoma and its possible viral cause. Following his return to England in 1966, he turned his attention to the cause of ‘Western Diseases’ especially the role of dietary fibre in the prevention of disease and promotion of health. This earned him even wider international recognition and helped to inspire what is a vital field of research today. The book examines Burkitt's personal views of the world around him, including his experiences as a committed evangelical Christian who had been raised an Irish Protestant, and the challenges, both familial and cultural, that this elicited from and towards him and his scientific work. The lymphoma and later the fibre story propelled Denis into an orbit of worldwide travel, fame and many honours. An engaging speaker but man of great humility, always giving the credit for much of what he did to others, he left a legacy of evidence and ideas for the causes of cancer and prevention of disease from which we all now benefit.
The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, such as Sugar and White Flour contends that the causation of these conditions has been obscured through confusing distinctions between unnatural, refined carbohydrates and that of natural, unrefined carbohydrates like fruits and whole meal flour. The author notes that all the foregoing conditions are really the manifestations of a single master-disease—that many of the major diseases of modern societies are caused by consuming unreasonable amounts of refined carbohydrate foods. The author discusses that in the short time that man has changed his diet, evolutionary adaptation is left behind. He gives two rules to prevent and arrest all saccharine disease manifestations: Do not eat any food unless you definitely want it, and avoid eating white flour or white sugar. These two rules will prevent gastric or duodenal ulcer, diabetes, coronary disease, constipation, complications of varicose veins, hemorrhoids, E. coli infections, obesity, and some skin conditions, As a retired Surgeon-General of the Royal Navy, the author bases his assumptions on evolutionary, epidemiological, and other scientific or historical work. This book can give insights to dieticians, food researchers, nutritionists, people on diet, and general medicine practioners.
This book summarizes current knowledge of the biology and molecular pathogenesis of aggressive lymphomas and reviews the state of the art in diagnostic and therapeutic strategies. The aim is both to provide the reader with a sound understanding of the very significant progress that has been achieved in the understanding and management of these malignancies over recent years and to facilitate appropriate choice of the therapeutic strategy in individual cases. The assessment of different prognostic parameters are clearly presented in order to permits effective risk stratification that impacts on treatment choice. Recent insights into lymphomagenesis are exemplified and may assist in identifying emerging therapeutic targets. The comprehensive and up-to-date nature of the book will make it an ideal reference for all physicians and researchers interested in lymphoma, including clinicians from various medical specialties, biologists, pathologists, radiologists and nuclear medicine specialist, as well as students.
The revised and expanded edition of the bestseller that changed millions of lives The science is clear. The results are unmistakable. You can dramatically reduce your risk of cancer, heart disease, and diabetes just by changing your diet. More than 30 years ago, nutrition researcher T. Colin Campbell and his team at Cornell, in partnership with teams in China and England, embarked upon the China Study, the most comprehensive study ever undertaken of the relationship between diet and the risk of developing disease. What they found when combined with findings in Colin's laboratory, opened their eyes to the dangers of a diet high in animal protein and the unparalleled health benefits of a whole foods, plant-based diet. In 2005, Colin and his son Tom, now a physician, shared those findings with the world in The China Study, hailed as one of the most important books about diet and health ever written. Featuring brand new content, this heavily expanded edition of Colin and Tom's groundbreaking book includes the latest undeniable evidence of the power of a plant-based diet, plus updated information about the changing medical system and how patients stand to benefit from a surging interest in plant-based nutrition. The China Study—Revised and Expanded Edition presents a clear and concise message of hope as it dispels a multitude of health myths and misinformation. The basic message is clear. The key to a long, healthy life lies in three things: breakfast, lunch, and dinner.
A decade ago Leaf, a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public's immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress-- brilliant young scientists-- are now abandoning the search for a cure.
Joanna Wilson and Gerhard May have assembled a collection of the key molecular biology protocols used in the analysis of Epstein-Barr virus (EBV), along with a series of valuable immunology, cell biology, and transgenic mouse protocols. These readily reproducible techniques include methods for gene expression with mini-EBV plasmids, for expression analysis by FISH, for EBV detection and quantitation, and for cell proliferation and death assays. In addition, there are EBV-based vectors, an up-to-date map of EBV, a comprehensive table of available latent protein antisera, and assays from in vitro to cell to organ to organism levels. Timely and highly practical, Epstein-Barr Virus Protocols provides powerful tools for elucidating the life cycle of EBV and its host interactions, work that promises the emergence of major new treatments and cures for EBV associated diseases, including several forms of human cancer.