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Human Brainstem: Cytoarchitecture, Chemoarchitecture, Myeloarchitecture explores how the human brainstem has been impeded by the unavailability of an up-to-date, comprehensive, diagrammatic and photographic atlas. Now, with the first detailed atlas on the human brainstem in more than twenty years, this book presents an accurate, comprehensive and convenient reference for students, researchers and pathologists. - Presents the first detailed atlas on the human brainstem in more than twenty years - Represents all areas of the medulla, pons and midbrain in the plane transverse to the longitudinal axis of the brainstem - Consists of 63 plates and 63 accompanying diagrams with an interplate distance of one millimeter - Includes photographs of Nissl and acetylcholinesterase (AChE) stained sections at alternate levels - Provides an accurate and convenient guide for students, researchers and pathologists
This work had its inception in 1945 when C. and O. Vogt suggested to one of us (J.O.) the need for investigation of the reticular formation of the brain stem. The Vogts felt that their studies of the extrapyramidal diseases, limited to an investigation of the basal ganglia, had illuminated only one aspect of the problem. In their opinion thorough knowledge of the morphological and functional organization of the reticular formation was indispensable for the understanding of the regulation and co-ordination of motor activity by the extraphyramidal systems. Accordingly, a study of the normal cytoarchitecture of the reticular formation was commenced at the Brain Research Institute, Neustadt, with the intention of applying this knowledge in the investigation of pathological material at a later date. For various reasons this work was interrupted for a period of several years, and it was not until 1952 that it was resumed at the Montreal Neurological Institute. It soon became apparent that it was advisable to extend the scope of the project to include the cytoarchitecture of all the gray masses of the lower brain stem. This conclusion was based largely on the lack of precise definition of the boundaries of the reticular formation and the insufficient data available concerning the cytoarchitecture of many nonreticular nuclei. At the present time the most comprehensive descriptions of the cytoarchitecture of the human brain stem are to be found in Jacobsohn's Uber die Kerne des menschlichen Hirnstamms " (1909) and in Ziehen's "Anatomie des Centralnervensystems" (1933). Jacobsohn's widely utilized drawings of cross sections of the brain stem constitute the most accurate guide at present available for delineation of the various nuclear masses. These drawings are necessarily overschematized due to their small size, and neither they nor the descriptions of nclei are supplemented by photomicrographs. Ziehen's exhaustive description of the cyto- and myeloarchitecture and fiber connections of the brain stem, supplemented by an extensive bibliography, suffers from the lack of representative serial cross sections stained for nerve cells. In addition the photomicrographs presented are limited to a few myelin stained preparations. Marburg devotes a considerable part of his atlas to the description of the cytoarchitecture of the human brain stem, but presents only five schematicrepresentationn of Nissl stained cross sections and includes no photomicrographs of this region. More cyoarchitectural detail of various regions of the human brain stem may be found in the monographs of Gagel and Bodechtal (1930), Stern (1936) and Crosby and Woodburne (1943), all of which are illustrated by excellent photomicrographs. Riley's "Atlas of the Basal Ganglia, Brain Stem and Spinal Cord" (1943), Although not directly concerned with cytoarchitecture, should be mentioned as an invaluable guide to any student of these regions. Apart from these comprehensive reviews, innumerable other investigators have confined their studies to the anatomy of individual brain stem nuclei. The presents work is an attempt to portray adequately and objectively the cytoarchitecture of all the nuclear structures of the medulla oblongata, pons and midbrain. In addition to the presentation of formerly recognized nuclei, several previously undescribed cell groups have been delineated on the basis of cytoarchitectonic criteria. The majority of these lie within the reticular formation. The contents of the monograph fall naturally into two parts. The first consists of a series of nineteen semischematic representative cross sections of the brain, stem, accompanied by low power photomicrographs. Descriptions of the individual nuclei, supplemented by photomicrographs of higher magnifications, compose the second part. It is hoped that this atlas will prove of value to the neuroanatomist who is interested in the position and morphology of the individual nuclei, and to the neuropathologist in his attempts to localize pathological processes and to distinguish abnormal cell forms from the confusing array of morphologically different normal cells found within various regions of the brain stem. Further, the neurophysiologist may find it useful to have available detailed human morphological data which can be correlated with that of experimental animals, and with which his functional concepts may be integrated.
Work on the human brainstem has been impeded by the unavailability of a comprehensive diagrammatic and photographic atlas. In the authors' preliminary work on the morphology of the human brainstem (The Human Nervous System, 1990), Paxinos et al demonstrated that it is possible to use chemoarchitecture to establish a number of human homologs in structures known to exist in the rat, the most extensively studied species. Now, with the first detailed atlas on the human brainstem in more than forty years, the authors present an accurate, comprehensive, and convenient reference for students, researchers, and pathologists. Key Features * The first detailed atlas on the human brainstem in more than forty years * Delineated as accurately as The Rat Brain in Stereotaxic Coordinates, Second Edition (Paxinos/Watson, 1986), the most cited book in neuroscience * Based on a single brain from a 59-year-old male with no medical history of neurological or psychiatric illness * Represents all areas of the medulla, pons, and midbrain in the plane transverse to the longitudinal axis of the brainstem * Consists of 64 plates and 64 accompanying diagrams with an interplate distance of half a millimeter * The photographs are of Nissl and acetylcholinesterase (AChE) stained sections at alternate levels * Establishes systematically the human homologs to nuclei identified in the brainstem of the rat Reviewed by leading neuroanatomists * An accurate and convenient guide for students, researchers, and pathologists
The previous two editions of the Human Nervous System have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the Atlas of the Human Brain, and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition. - Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. Atlas of the Human Brain (new edition in 2007) - Full color throughout with many new and significantly enhanced illustrations - Provides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Ideal for students of neuroscience and neuroanatomy, the new edition of Netter's Atlas of Neuroscience combines the didactic well-loved illustrations of Dr. Frank Netter with succinct text and clinical points, providing a highly visual, clinically oriented guide to the most important topics in this subject. The logically organized content presents neuroscience from three perspectives: an overview of the nervous system, regional neuroscience, and systemic neuroscience, enabling you to review complex neural structures and systems from different contexts. You may also be interested in: A companion set of flash cards, Netter's Neuroscience Flash Cards, 3rd Edition, to which the textbook is cross-referenced. Coverage of both regional and systemic neurosciences allows you to learn structure and function in different and important contexts. Combines the precision and beauty of Netter and Netter-style illustrations to highlight key neuroanatomical concepts and clinical correlations. Reflects the current understanding of the neural components and supportive tissue, regions, and systems of the brain, spinal cord, and periphery. Uniquely informative drawings provide a quick and memorable overview of anatomy, function, and clinical relevance. Succinct and useful format utilizes tables and short text to offer easily accessible "at-a-glance" information. Provides an overview of the basic features of the spinal cord, brain, and peripheral nervous system, the vasculature, meninges and cerebrospinal fluid, and basic development. Integrates the peripheral and central aspects of the nervous system. Bridges neuroanatomy and neurology through the use of correlative radiographs. Highlights cross-sectional brain stem anatomy and side-by-side comparisons of horizontal sections, CTs and MRIs. Features video of radiograph sequences and 3D reconstructions to enhance your understanding of the nervous system. Student Consult eBook version included with purchase. This enhanced eBook experience includes access -- on a variety of devices -- to the complete text, 14 videos, and images from the book. Expanded coverage of cellular and molecular neuroscience provides essential guidance on signaling, transcription factors, stem cells, evoked potentials, neuronal and glial function, and a number of molecular breakthroughs for a better understanding of normal and pathologic conditions of the nervous system. Micrographs, radiologic imaging, and stained cross sections supplement illustrations for a comprehensive visual understanding. Increased clinical points -- from sleep disorders and inflammation in the CNS to the biology of seizures and the mechanisms of Alzheimer's -- offer concise insights that bridge basic neuroscience and clinical application.
This book is unique in that it provides the reader with the most up-to-date terminology used to describe the human nervous system (central and peripheral) and the related sensory organs, i.e., the Terminologia Neuroanatomica (TNA), the official terminology of the IFAA (International Federation of Associations of Anatomists). The book provides a succinct but detailed review of the neuroanatomical structures of the human body and will greatly benefit not only various specialists such as (neuro)anatomists, neurologists and neuroscientists, but also students taking neuroanatomy and neuroscience courses. The book offers a high yield, combined presentation of neuroanatomical illustrations and text and provides the reader a ‘one-stop source’ for studying the intricacies of the human nervous system and its sensory organs. It includes an alphabetical list of official English terms and synonyms with the official Latin terms and synonyms from the TNA. With regard to the entries, the name of the item in standardized English is provided, followed by synonyms and the official TNA Latin term, Latin synonyms and eponyms, a short description and in many cases one or more illustrations. To facilitate the use of illustrations, certain entries such as the gyri or sulci of the cerebral cortex are presented together with extensive cross-references. Terms that form part of a certain structure (such as the amygdaloid body, the thalamus and the hypothalamus) are listed under the respective structure. Segments and branches of arteries are discussed under the main artery, for example the A1–A5 segments under the anterior cerebral artery. Most nerves can be found following their origin from the brachial, cervical and lumbosacral plexuses. However, the major nerves of the limbs are discussed separately, as are the cranial nerves. Nuclei can be found by their English name or under Nuclei by their eponym.