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Comprehensive and up to date, the Second Edition of Diagnostic Pathology: Infectious Disease, by Dr. Richard Kradin, is an invaluable tool for the accurate diagnosis of any infectious disease―from the common to the most challenging. The organ-based format makes it an especially useful tool for surgical pathologists' daily diagnostic and management issues. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion, clearly depicting how to recognize the morphology of organisms and the spectrum of histological responses that they may cause. - Addresses the most difficult diagnostic issues that practicing or trainee surgical pathologists face when handling infectious disease tissue specimens. - Highlights morphological characteristics and landmarks of tissue samples for easy access to information necessary for signing out a specimen. - Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. - Completely revised with the latest diagnostic support and hot topics in the field: - A new chapter on novel techniques in microbiology - A new chapter on eye infections - New coverage of immunohistochemical staining and other molecular diagnostic techniques - New discussions of human papillomavirus, a critical tool in predictive cancer screening - New information on infections in the immunocompromised host and related special considerations - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.
Current and Emerging Technologies in Microbial Diagnostics, the latest volume in the Methods in Microbiology series, provides comprehensive, cutting-edge reviews of current and emerging technologies in the field of clinical microbiology. The book features a wide variety of state-of-the art methods and techniques for the diagnosis and management of microbial infections, with chapters authored by internationally renowned experts. This volume focuses on current techniques, such as MALDI-TOF mass spectroscopy and molecular diagnostics, along with newly emerging technologies such as host-based diagnostics and next generation sequencing. - Written by recognized leaders and experts in the field - Provides a comprehensive and cutting-edge review of current and emerging technologies in the field of clinical microbiology, including discussions of current techniques such as MALDI-TOF mass spectroscopy and molecular diagnostics - Includes a broad range and breadth of techniques covered - Presents discussions on newly emerging technologies such as host-based diagnostics and next generation sequencing
Rapid multiplex detection of pathogens in the environment and in our food is a key factor for the prevention and effective treatment of infectious diseases. Biosensing technologies combining the high selectivity of biomolecular recognition and the sensitivity of modern signal detection platforms are a prospective option for automated analyses. They allow rapid detection of single molecules as well as cellular substances. This book, including 12 chapters from 50 authors, introduces the principles of identification of specific pathogen biomarkers along with different biosensor-based technologies applied for pathogen detection.
Infectious diseases remain a leading cause of prolonged illness, premature mortality, and soaring health costs. In the United States in 1995, infectious diseases were the third leading cause of death, right behind heart disease and cancer. Mortality is mounting over time, owing to HIV/AIDS, pneumonia, and septicemia, with drug resistance playing an ever-increasing role in each of these disease categories. This book, a report from a Forum on Emerging Infections workshop, focuses on product areas where returns from the market might be perceived as being too small or too complicated by other factors to compete in industrial portfolios with other demands for investment. Vaccines are quintessential examples of such products. The lessons learned fall into four areas, including what makes intersectoral collaboration a reality, the notion of a product life cycle, the implications of divergent sectoral mandates and concepts of risk, and the roles of advocacy and public education. The summary contains an examination of the Children's Vaccine Initiative and other models, an industry perspective on the emerging infections agenda, and legal and regulatory issues.
This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.
This book fully updates and builds upon its first edition. Beginning with chapters on epidemiology and population genetics, it continues with sections covering genomics and gene expressions, fitness mutation and physiology, and the detection of resistance.
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
The genus Salmonella comprises an important number of bacterial species able to colonize and infect numerous animal species and humans. Although more than a hundred years passed since its discovery, Salmonella still represents a redoubtable and successful microorganism, difficult to deal with. Whether we discuss about typhoid fever or food poisoning, the public health and financial consequences are practically incalculable. The costs attributable to Salmonella contamination of meat, eggs, and vegetables are also very high worldwide. Antimicrobial resistance in Salmonella isolates is an emerging threat not only in humans, and special measures should be addressed to this global problem. The book Current Topics in Salmonella and Salmonellosis contains a series of reviews about all-important issues concerning these subjects. It comprises 14 chapters grouped in 4 sections emphasizing new insights into pathogenesis, bacterial detection and antibiotic resistance, infections in animals, risk factors, and control strategies. The new genomic data and the exhaustive presentation of molecular pathogenesis bring novelty to the book and can help to improve our knowledge about Salmonella-induced diseases.
This manual provides an authoritative guide to standard laboratory procedures for detecting and diagnosing sexually transmitted diseases. Addressed to clinical microbiologists and medical technologists, the manual is designed to serve as a practical bench aid, tuned to the needs and capacities of laboratories at different levels in the health system. Although the standard procedures described have universal relevance, particular attention is given to conditions in developing countries, where rapid transport of specimens may not be possible and cost factors may be decisive. Recommended procedures, tests, and techniques are supported by close to 150 references. Noting the constraints on staff and resources faced by most laboratories throughout the world, the manual concentrates on tests known to yield essential diagnostic information. Standard antimicrobial susceptibility tests are described for those diseases where drug resistance is a problem. Although the major emphasis is on procedures for diagnosis, case-finding, and test-of-cure, some procedures useful in epidemiological research are also included. The manual has nine chapter covering the full range of sexually transmitted diseases: gonorrhoea "Chlamydia trachomatis "infection, syphilis, genital herpes, chancroid granuloma inguinale, vaginitis in adults, human papillomavirus infection, and human immunodeficiency virus. Each chapter opens with a brief description of the disease and the principal laboratory approaches to diagnosis, followed by detailed advice on the collection and transport of specimens. Against this background, all relevant laboratory methods, from microscopy, culture and non-culture techniques to serology and the use of commercial test kits, are described in detail, with colour plates used to illustrate selected procedures and results. Apart from providing detailed step-by-step instructions for each procedure, the manual offers abundant practical advice on the selection of tests, their comparative sensitivity, and specificity, the degree of skill required, the correct interpretation of results, and common errors and how to avoid them. The chapter on HIV infection reproduces the latest joint UNAIDS and WHO recommendations for the selection and use of HIV antibody tests. Further practical guidance for each of these diseases is provided in three annexes, which summarize appropriate diagnostic tests at different levels of the laboratory system, describe the media, reagents, and stains required for the tests, and list all the basic products needed to prepare essential reagents and media.