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Presents a class of young armadillos being taught armadillo facts, and why they should never cross a road.
Chicken wants to cross the road. His friends on the other side eat popsicles for lunch, play Duck Duck Goose and invite him to join the fun. But Chicken's fears hold him back, fears that are magnified by his parents, who screech and cluck their warnings about the hazards of crossing. Will Chicken overcome his fears? In the end, his pluck and ingenuity take the story to a smart and satisfying free-range conclusion.
Emma Howe finally meets a man who lights her up..and then promptly turns him into a floor lamp. Yes, that’s right. Floor lamp. Dangling pull switch, shade, and all. After spending years trying to get her magic to behave, Emma finally admits the truth. She’s the worst witch ever, and she should just give up. On magic. On any hope for love. Until her cousin convinces her to try a magical dating app, and it pairs her with a gargoyle shifter named…of all things…Stone. Stone didn’t want to come to Salem. But when his boss at the Agency of Magic, Unusual Licensing, and Extraordinary Things orders him to track down a demon who’s eluded capture for more than twenty-five years, he doesn’t have much choice. AMULET wants the trickster contained, but every time Stone gets close to the demon’s magical trail, it turns colder than an iceberg. What's a gargoyle shifter supposed to do for fun when he's on assignment in a strange town? Sign up for a dating app, of course. It’s all fun and games until he gets turned into a lamp and thrown in the trunk of a car—with an unconscious Emma. Will he ever be flesh and bone again? Or will an unknown force harness the demon’s magical energy for their own dark purposes and leave Emma and her lamp in the dark…forever?
‘You are going to die. You will die like the policeman in the hotel, but this time your family won’t escape.’ Prepare to be swept away by the thrilling story of Dead Don't Cross The Line, the first book in The Nexus series, where danger, intrigue and betrayal await you at every turn. Rachel Barnes, former Brazilian Federal Police agent, now at DRT International Investigations Ltd. in London, alongside her partners: David, a former FBI strategist, and Tyler, a former RCMP tactical specialist. Their ordinary world is catapulted into chaos when they hear of a frightening threat from a Japanese prisoner in Shanghai. This sinister prophecy sets Rachel on a collision course with her past, revealing a dark secret: her ex-partner, the so-called “policeman in the hotel,” whose death was ruled an accident. As they delve deeper into the complex network of Chinese organized crime in the city of Shanghai, Rachel finds herself in the crosshairs of an enemy more ruthless than any she has ever faced. Her life is at stake and each clue brings her closer to a deadly truth that could destroy everything she believes in. Dare to immerse yourself in this gripping narrative, where each page crackles with tension and each chapter brings you closer to an unpredictable ending. Dead Don't Cross The Line promises a reading experience that captivates, challenges, and ultimately leaves you wanting more.
Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
Conventional CD8+ and CD4+ T cells recognize antigens, presented by antigen-presenting cells in the form of short peptides loaded onto major histocompatibility complex (MHC) class I and class II molecules, through their T cell receptor (TCR). Somatic gene rearrangement of the TCR locus and randomization of TCR hyper-variable regions generate the marked diversity of TCRs. Once assembled, the heterodimeric TCR confers specificity to naïve T cells. The naïve T cell repertoire of an individual is established by selection processes in the thymus and cannot be broadened upon antigen recognition by additional somatic mutations. In humans, the estimated number of distinct TCRs in the naïve T cell pool is several orders of magnitude lower than the possible array of peptides that can be generated and accommodated into an MHC molecule. This challenge can be overcome by T cell cross-reactivity, that is the ability of a single TCR to bind multiple peptide-MHC complexes. T-cell cross-reactivity can have both positive and negative consequences. First, it allows for covering a wide range of foreign peptides with a limited repertoire of T cells. Second, it facilitates polyclonal immune responses to a single peptide and increases resistance to escape mutations. Third, it can induce heterologous immunity, that is the generation of memory to a pathogen different from the one against which the immune response has been originally raised. On the contrary, a negative consequence of T-cell cross-reactivity is the possibility of self-antigen recognition, potentially causing autoimmunity. The lower activation threshold of memory T-cells compared to naïve T-cells increases this risk, partially eluding the thymic negative selection checkpoint. Moreover, heterologous immunity can be detrimental when the type of memory T-cell polarization induced by the first pathogen is inappropriate to control the second pathogen.
The ultimate myth-busting collection of quirky and curious facts about your body and health In 2009, Drs. Aaron E. Carroll and Rachel C. Vreeman explored a wide range of myths and misconceptions about our bodies and health in the media sensation, Don't Swallow Your Gum!, featured on The Dr. Oz Show, CNN, and in The New York Times, USA Today, and more. Now, they're delving into a whole new collection of myths based on the latest scientific research, including: • Eggs give you high cholesterol. • You should stretch before you exercise. • Kids in day care catch more colds. • Sit-ups or crunches will flatten your stomach. • A glass of warm milk will put you to sleep. With a perfect balance of authoritative research and breezy humor, Don't Cross Your Eyes . . . They'll Get Stuck That Way! exposes the truth behind all of the things you thought you knew about your health, your well-being, and how the body works.