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This text investigates the molecular biology of conjugation, and the subsequent activity of the transfered genes "in vivo". Conjugation may be very important when considering biotransformations, as expression of transfered genes may allow organisms to metabolize certain substrates.
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
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In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students throu
Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations. The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug ...
Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.
Understanding Drug Action: An Introduction to Pharmacology provides readers with a survey of the scientific understanding of drug action. This readable introduction to pharmacology is simple enough to be understood without having to take a class to follow the material, but can also be used to complement a course in pharmacology. The approach to pharmacology is at a basic scientific level to build a framework of how drugs work supplemented with information on some representative drugs that are used clinically. Each chapter includes review questions and many chapters include tables of important drugs with brand and generic names.
A rigorous, high-yield review for the new ABA Part 1: BASIC Examination The year 2014 marks the beginning of a new phase in board certification for anesthesiology residents in the United States. The Part 1 exam is now split into two written examinations: Basic and Advanced. Anesthesiology. Residents who are unable to pass the Basic examination will not be allowed to finish their training. That's why this book is a true must read for every anesthesiology resident. It is the single best way to take the stress out of this make-or-break exam, focus your study on nearly 200 must-know topics found on the board exam outline, and identify your areas of strength and weakness. Written by program directors with many years of board examination advising experience, Anesthesiology Core Review Part One: BASIC Exam is designed to be the cornerstone of your study preparation. Each chapter of Anesthesiology Core Review succinctly summarizes key concepts in basic science and clinical anesthesia practice. Space is conveniently provided throughout the book to add notes from other study resources. Anesthesiology Core Review Part One: BASIC Exam is logical divided into four sections: Basic Science Clinical Sciences Organ-Based Sciences Special Issues in Anesthesiology (covering important topics such as professionalism and licensure, ethics, and patient safety) With its expert authorship and concise yet thorough coverage, Anesthesiology Core Review Part One: BASIC Exam is biggest step you can take to assure effective preparation for the new ABA BASIC Examination.
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. - Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. - Provides in vivo and in vitro models to study human liver pathology. - Explains the beneficial effects of antioxidants on liver diseases. - Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.