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Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separation and analysis of chiral substances. The text addresses the newest advances in TLC instrumentation, two-dimensional TLC, quantification by slit scanning densitometry and image analysis, statistical processing of data, and various detection and identification methods. It also describes the use of TLC for solving a key issue in the drug market—the presence of substandard and counterfeit pharmaceutical products. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups. Each chapter contains an introduction about the structures and medicinal actions of the described substances and a literature review of their TLC analysis. A useful resource for chromatographers, pharmacists, analytical chemists, students, and R&D, clinical, and forensic laboratories, this book can be utilized as a manual, reference, and teaching source.
This guide for the practicing chromatographer who wants a ready source of information on HPLC detection explores and compares existing detection systems and detectors, outlines the common problems associated with a given detector, and offers proven approaches to avoiding such problems. - Addresses the practical aspects of HPLC detection, including: basic theory, when a particular type of detector can be used, how detectors from various manufacturers differ, common problems of detectors and ways to avoid them - Presents an overview of today's most common techniques - Discusses the advantages and disadvantages of HPLC, dispelling common misconceptions
For food scientists, high-performance liquid chromatography (HPLC) is a powerful tool for product composition testing and assuring product quality. Since the last edition of this volume was published, great strides have been made in HPLC analysis techniques-with particular attention given to miniaturization, automatization, and green chemistry. Tho
Theory and practice of HPLC; Applications of HPLC to food analysis; Determination of carborydrates; The analysis of lipids by HPLC; Determination of vitamins; Determination of food additives by HPLC; Determination of synthetic food colours by HPLC; HPLC of natural pigments in foodstuffs; Determination of mycotoxins; Determination of polynuclear aromatic hydrocarbons and nitrosamines; Determination of pesticide residues; Determination of amino acids; liquid chromatography/mass spectrometry.
The conventional solvents used in chemical, pharmaceutical, biomedical and separation processes represent a great challenge to green chemistry because of their toxicity and flammability. Since the beginning of “the 12 Principles of Green Chemistry” in 1998, a general effort has been made to replace conventional solvents with environmentally benign substitutes. Water has been the most popular choice so far, followed by ionic liquids, surfactant, supercritical fluids, fluorous solvents, liquid polymers, bio-solvents and switchable solvent systems. Green Solvents Volume I and II provides a throughout overview of the different types of solvents and discusses their extensive applications in fields such as extraction, organic synthesis, biocatalytic processes, production of fine chemicals, removal of hydrogen sulphide, biochemical transformations, composite material, energy storage devices and polymers. These volumes are written by leading international experts and cover all possible aspects of green solvents’ properties and applications available in today’s literature. Green Solvents Volume I and II is an invaluable guide to scientists, R&D industrial specialists, researchers, upper-level undergraduates and graduate students, Ph.D. scholars, college and university professors working in the field of chemistry and biochemistry.
This book is a comprehensive guide to forensic analytical toxicology for trainees in forensic medicine and forensic scientists. The second edition has been fully revised to provide clinicians with the latest developments and research in the field. New chapters covering the latest analytical instruments have been added to this edition. Beginning with guidance on setting up a modern toxicology laboratory, the next sections, with the help of flow charts, explain the procedures for collection, preservation, extraction, and clean up; and screening and colour tests for various poisons. The following chapters describe numerous major and minor analytical instruments and techniques, and their application in forensic toxicology. The text is further enhanced by clinical images, figures and tables. The previous edition (9789351522249) published in 2014.
This book presents the applications of ion-exchange materials in the biomedical industries. It includes topics related to the application of ion exchange chromatography in determination, extraction and separation of various compounds such as amino acids, morphine, antibiotics, nucleotides, penicillin and many more. This title is a highly valuable source of knowledge on ion-exchange materials and their applications suitable for postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology. Additionally, this book will provide an in-depth knowledge of ion-exchange column and operations suitable for engineers and industrialists.
Introduces the reader to the field of ion chromatography, species analysis and hyphenated methods IC-MS and IC-ICP-MS including the theory and theirs applications Covers the importance of species analysis and hyphenated methods in ion chromatography Includes practical applications of IC-MS and IC-ICP-MS in environmental analysis Details sample preparation methods for ion chromatography Discusses hyphenated methods IC-MS and IC-ICP-MS used in determining both the total element contents and its elements Details speciation analysis used in studying biochemical cycles of selected chemical compounds; determining toxicity and ecotoxicity of elements; food and pharmaceuticals quality control; and in technological process control and clinical analytics