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The 7th International Conference on Computer Applications in Biotechnology (CAB7) was held in Osaka on May 31- June 4, 1998. CAB7 was the continuation of a successful series of conferences which addressed all major areas in which computers are used to aid process analysis, synthesis, supervision, diagnosis, operation, optimization, control and other biotechnological procedures. Essential bioprocess system engineering aspects ranging from metabolic engineering to the control of bioproduction plants were covered. CAB7 was supported by the International Federation of Automatic Control, the European Federation of Biotechnology, and the Society of Fermentation and Bioengineering, Japan. The scientific program was arranged in several sessions. Titles of the sessions were: Modeling, simulation, design and optimization of bioprocesses; Robotics in biotechnology; Knowledge engineering approaches for bioprocess operation; Computer application in metabolic engineering; Instrumentation and data processing; Cell culture engineering and clinical application; and Application to environmental engineering. Leading international figures in their fields presented papers of the latest information. All papers selected were reviewed with the assistance of the international organizing committee (IPC). In total, 94 high quality papers are complied in this volume.
Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.
This volume deals with "Microbial Production of L-Amino Acids" and presents five comprehensive, expert and actual review articles on the modern production of Amino Acids by application of biotechnologically optimized microorganisms. This includes not only the modern techniques of enzyme, metabolic and transport engineering but also sophisticated analytical methods like metabolic flux analysis and subsequent pathway modeling. A general review about industrial processes of Amino Acid production provides a comprehensive overview about recent strain development as well as fermentation technologies. It was our special interest to focus the other articles on the most important and best selling amino acids on the world market i.e. L-Glutamate, L-Lysine and L-Threonine. The authors of this special volume have contributed significantly to the progress of Amino Acid biotechnology in the last decades and earn our special gratitude and admiration for their expert review articles.
Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.
This title was first published in 2000: This text presents a study of collective learning, networking and high-technology regions in Europe. It first provides an overview of the subject area, then goes on to discuss topics such as the role of inter-SME networking and collective learning processes in European high-technology milieux.
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