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There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases explains how the search for new substances effective against mosquitoes and their diseases has benefited from the use of in silico techniques. QSAR modeling is suited to identify the key structural features and/or physicochemical properties explaining an activity and to propose candidate molecules for further evaluation by laboratory tests. Homology modeling is useful to approximate the 3D structure of proteins of interest. Pharmacophore modeling is a powerful means to capture the chemical features responsible for an activity and to identify new potentially active compounds via the virtual screening of databases. Fugacity modeling and a wealth of other modeling paradigms are useful for risk assessment in vector borne disease control.
There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases explains how the search for new substances effective against mosquitoes and their diseases has benefited from the use of in silico techniques. QSAR modeling is suited to identify the key structural features and/or physicochemical properties explaining an activity and to propose candidate molecules for further evaluation by laboratory tests. Homology modeling is useful to approximate the 3D structure of proteins of interest. Pharmacophore modeling is a powerful means to capture the chemical features responsible for an activity and to identify new potentially active compounds via the virtual screening of databases. Fugacity modeling and a wealth of other modeling paradigms are useful for risk assessment in vector borne disease control.
Big Data Analytics in Chemoinformatics and Bioinformatics: With Applications to Computer-Aided Drug Design, Cancer Biology, Emerging Pathogens and Computational Toxicology provides an up-to-date presentation of big data analytics methods and their applications in diverse fields. The proper management of big data for decision-making in scientific and social issues is of paramount importance. This book gives researchers the tools they need to solve big data problems in these fields. It begins with a section on general topics that all readers will find useful and continues with specific sections covering a range of interdisciplinary applications. Here, an international team of leading experts review their respective fields and present their latest research findings, with case studies used throughout to analyze and present key information. - Brings together the current knowledge on the most important aspects of big data, including analysis using deep learning and fuzzy logic, transparency and data protection, disparate data analytics, and scalability of the big data domain - Covers many applications of big data analysis in diverse fields such as chemistry, chemoinformatics, bioinformatics, computer-assisted drug/vaccine design, characterization of emerging pathogens, and environmental protection - Highlights the considerable benefits offered by big data analytics to science, in biomedical fields and in industry
Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological values. A volume in the Exploring Medicinal Plants series, this book highlights trends, technologies, processes, and services important to and necessary for efficient production, use, and understanding of medicinal qualities of antimalarial plants. It critically examines claims made by traditional medical practitioners with scientific validations for safe herbal drug formulation. It is a reference work for researchers of herbal medicine, traditional healers, pharmacists, and students associated with plant sciences and economic botany.
March 18-20, 2019 Edinburgh, Scotland Bio-Pharmaceutics,Pharmaceutical Chemistry,Drug Targeting and Design,Pharmacokinetics and Pharmacodynamics in Drugs,Pharmaceutical Formulation,Pharmaceutical Manufacturing,Pharmaceutical Nanotechnology,Novel Drug Delivery Systems,Smart Drug Delivery Systems,Nanomedicine and Biomedical Applications,Biomaterials in Drug Delivery,Vaccine Drug Delivery Systems,Medical Devices for Drug Delivery,Biologics & Biosimilars,Pharmaceutical Analysis,Pharmaceutical Process Validation,Pharmaceutical Packaging,Clinical Trials and Clinical Research,Pharmacogenetics and Genomics,Regulatory Affairs and Intellectual Property Rights,Industrial and Physical Pharmacy,Clinical and Hospital Pharmacy,Pharmacovigilance and Drug Safety,Pharmacy Education and Practice,
Matrix metalloproteinases (MMPs) have been established as promising biomolecular targets for novel drug design and discovery against numerous major disease conditions including various cancers, cardiovascular, neurodegenerative, inflammatory diseases, and more. This book covers various modern molecular modeling methodologies particularly related to MMP inhibitors. Included in the text are descriptions of ligand-based drug designing and structure-based drug designing modeling strategies for designing potential and target specific or selective MMPIs. This book will benefit those who are looking for an in-depth text on the design and discovery processes of novel and selective MMPIs. Features Describes modeling strategies applied to MMPs Elaborates on the designing strategies of MMPs specifically Includes in-depth analyses of related case studies Acts as a guide for medicinal chemists, not only from pharmaceutical industries, but also from academia Covers various modern molecular modeling methodologies, particularly related to MMPIs
Advances in Arthropod Repellents offers the most current knowledge on arthropod repellents. This area of study is quickly evolving as mosquito- and tick-borne diseases become more prevalent worldwide. Written by global arthropod repellent experts, this book begins by delving into molecule discovery and assay development that is followed by the latest research and investigations of repellent developments and effects. The book then offers readers a look into the global field, semi-field, and laboratory trials using various insect repellents, ranging from Africa, Australia, Europe, South America and the United States. Lastly, it examines the future of spatial repellents and expert insight. This book is a valuable resource for entomologists and vector control researchers and practitioners. Public health officials and developers in private pest control companies, as well as readers in academia will find this a useful resource to learn the latest information available on controlling the spread of arthropod-borne diseases with repellents. - Discusses recent progress on understanding how insect repellents work, as well as modern methods for finding new molecules and formulations - Edited by a team whose expertise includes cutting-edge insect repellent research and development - Serves as a reference and resource that will be useful to a wide variety of professionals, particularly those in public health and vector control
In this book is reported novel information on diagnosis, treatment, and control of parasites that are naturally transmitted from animal reservoirs to humans. Subjects: Public Health and Healthcare: Prevention; Medicine and Pharmacology: Therapy.
As doctors and biologists have learned, to their dismay, infectious disease is a moving target: new diseases emerge every year, old diseases evolve into new forms, and ecological and socioeconomic upheavals change the transmission pathways by which disease spread. By taking an approach focused on the general evolutionary and ecological dynamics of disease, this Very Short Introduction provides a general conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the 'where', 'why', 'how', and 'what' questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another, and why are some individuals more susceptible than others? What biochemical, ecological, and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level, or to block infection at the individual level? Through a series of case studies, Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way, emphasising the general principles of infection, the management of outbreaks, and the evolutionary and ecological approaches that are now central to much research about infectious disease. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths. Comprehensive coverage of molecular processes in olfaction of vertebrates and insects Focus on the emerging field of insect olfaction Contributions by leading research groups in their fields, from a range of countries Discusses fundamental knowledge and also key applications being addressed by the research