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Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. - Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings - Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung - Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more - Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.
Hopefully, this book will be taken off of the shelf frequently to be studied carefully over many years. More than 40 researchers were involved in this project, which examines respiration, circulation, and metabolism from ?sh to the land vertebrates, including human beings. A breathable and stable atmosphere ?rst appeared about 500 million years ago. Oxygen levels are not stable in aquatic environments and exclusively water-breathing ?sh must still cope with the ever-changing levels of O 2 and with large temperature changes. This is re?ected in their sophisticated count- current systems, with high O extraction and internal and external O receptors. 2 2 The conquest for the terrestrial environment took place in the late Devonian period (355–359 million years ago), and recent discoveries portray the gradual transitional evolution of land vertebrates. The oxygen-rich and relatively stable atmospheric conditionsimpliedthatoxygen-sensingmechanismswererelativelysimpleandl- gain compared with acid–base regulation. Recently, physiology has expanded into related ?elds such as biochemistry, molecular biology, morphology and anatomy. In the light of the work in these ?elds, the introduction of DNA-based cladograms, which can be used to evaluate the likelihood of land vertebrates and lung?sh as a sister group, could explain why their cardio-respiratory control systems are similar. The diffusing capacity of a duck lung is 40 times higher than that of a toad or lung?sh. Certainly, some animals have evolved to rich high-performance levels.
The central focus of this book is the avian respiratory system. The authors explain why the respiratory system of modern birds is built the way it is and works the way that it does. Birds have been and continue to attract particular interest to biologists. The more birds are studied, the more it is appreciated that the existence of human-kind on earth very much depends directly and indirectly on the existence of birds. Regarding the avian respiratory system, published works are scattered in biological journals of fields like physiology, behavior, anatomy/morphology and ecology while others appear in as far afield as paleontology and geology. The contributors to this book are world-renowned experts in their various fields of study. Special attention is given to the evolution, the structure, the function and the development of the lung-air sac system. Readers will not only discover the origin of birds but will also learn how the respiratory system of theropod dinosaurs worked and may have transformed into the avian one. In addition, the work explores such aspects as swallowing mechanism in birds, the adaptations that have evolved for flight at extreme altitude and gas exchange in eggs. It is a highly informative and carefully presented work that provides cutting edge scientific insights for readers with an interest in the respiratory biology and the evolution of birds.
Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.
A panel of recognized authorities comprehensively review the medical, surgical, and pathophysiologic issues relevant to lung volume reduction surgery for emphysema. Topics range from the open technique and video-assisted thoracoscopic approaches to LVRS, to anesthetic management, to perioperative and nursing care of the patient. The experts also detail the selection of candidates for LVRS, the clinical results and clinical trials in LVRS, and the effects of LVRS on survival rates.
Biology and Evolution of Crocodylians is a comprehensive review of current knowledge about the world's largest and most famous living reptiles. Gordon Grigg's authoritative and accessible text and David Kirshner's stunning interpretive artwork and colour photographs combine expertly in this contemporary celebration of crocodiles, alligators, caimans and gharials. This book showcases the skills and capabilities that allow crocodylians to live how and where they do. It covers the biology and ecology of the extant species, conservation issues, crocodylian–human interaction and the evolutionary history of the group, and includes a vast amount of new information; 25 per cent of 1100 cited publications have appeared since 2007. Richly illustrated with more than 500 colour photographs and black and white illustrations, this book will be a benchmark reference work for crocodylian biologists, herpetologists and vertebrate biologists for years to come.
Medicine is grounded in the natural sciences, where biology stands out with regard to our understanding of human physiology and the conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, the macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system. Moreover, many adaptations to past ecologies have actually turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. One could add depression, anxiety, and other psychiatric conditions to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of up-to-date insights into the evolutionary history of ourselves as a species, exploring how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine is valuable reading for students as well as scholars in the fields of medicine, biology, anthropology and psychology.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
How did flying birds evolve from running dinosaurs, terrestrial trotting tetrapods evolve from swimming fish, and whales return to swim in the sea? These are some of the great transformations in the 500-million-year history of vertebrate life. And with the aid of new techniques and approaches across a range of fields—work spanning multiple levels of biological organization from DNA sequences to organs and the physiology and ecology of whole organisms—we are now beginning to unravel the confounding evolutionary mysteries contained in the structure, genes, and fossil record of every living species. This book gathers a diverse team of renowned scientists to capture the excitement of these new discoveries in a collection that is both accessible to students and an important contribution to the future of its field. Marshaling a range of disciplines—from paleobiology to phylogenetics, developmental biology, ecology, and evolutionary biology—the contributors attack particular transformations in the head and neck, trunk, appendages such as fins and limbs, and the whole body, as well as offer synthetic perspectives. Illustrated throughout, Great Transformations in Vertebrate Evolution not only reveals the true origins of whales with legs, fish with elbows, wrists, and necks, and feathered dinosaurs, but also the relevance to our lives today of these extraordinary narratives of change.