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This open access book focuses on Switzerland-based medium-sized companies with a longstanding export tradition and a proven dominance in global niche markets. Based upon in-depth documentation and analysis of 36 Swiss companies over their entire history, an expert team of authors presents several parallels in the pathways and success factors which allowed these firms to become dominant and operate from a high-cost location such as Switzerland. The book enhances these insights by providing detailed company profiles documenting the company history, development, and how their relevant global niche positions were reached. Readers will benefit from these profiles as they compile a diverse selection of industries, mainly active within the B2B sector, with mostly mature companies (60 years to older than 100 years since founding) and different types of ownership structures including family firms. ‘Masterpieces of Swiss Entrepreneurship’ brings unique learning opportunities to owners and leaders of SMEs in Switzerland and elsewhere. Findings are based on detailed bottom-up research of 36 companies -- without any preconceived notions. The book is both conceptual and practical. It fosters understanding for different choices in development pathways and management practices. Matti Alahuhta, Chairman DevCo Partners, ex-CEO Kone, Board member of several global listed companies, Helsinki, Finland Start-up entrepreneurs need proven models from industry which demonstrate the various paths to success. “Masterpieces of Swiss Entrepreneurship” provides deep insights highlighting these models and the important trade-offs entrepreneurial teams must consider when choosing the path of high growth or of maximum control, as they are often mutually exclusive. Gina Domanig, Managing Partner, Emerald Technology Ventures, Zurich
This document brings together a set of the latest data points and publicly available information relevant to the Retail & Consumer Goods Industry. We are very excited to share this content and believe that readers will benefit from this periodic publication immensely.
This book is filled with real-life personal stories, testimonies, prayers, scriptures, and answers to help women find wisdom, strength and salvation. Each thought-provoking story is concluded with a light-hearted story providing readers with lots of laughter.
Are humans just complex biochemical machines, mere physical parts of a causally closed materialist universe? Are we approaching the so-called "Singularity" when human consciousness can (and will) be downloaded into computers? Or is there more to the human person--something that might be known as soul or spirit? As this book makes clear, the answers to these questions have profound implications to topics such as heroism, creativity, ecology, and the possibility of reason and science. In exploring this important topic, Dickerson engages the ideas of some well-known twentieth- and twenty-first-century espousers of physicalism, including philosopher Daniel Dennett (Consciousness Explained), biologist Richard Dawkins (The God Delusion), futurist-engineer Raymond Kurzweil (The Age of Spiritual Machines), psychologist B. F. Skinner (Beyond Freedom and Dignity), and mathematician-philosopher Bertrand Russell (Why I Am Not a Christian). Through a careful reading of their works, Dickerson not only provides a five-fold critique of physicalism, but also offers a Christian alternative in the form of "integrative dualism," which affirms the existence of both a physical and spiritual reality without diminishing the goodness or importance of either, and acknowledges that humans are spiritual as well as bodily persons.
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.