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Since 1992, when it began as the Medicine Meets Virtual Reality conference, NextMed/MMVR has been a forum for researchers utilizing IT advances to improve diagnosis and therapy, medical education, and procedural training. Scientists and engineers, physicians and other care providers, educators and students, military medicine specialists, futurists, and industry all come together with the shared goal of making healthcare more precise and effective.This book presents the proceedings of the 20th NextMed/MMVR conference, held in San Diego, California, USA, in February 2013. It covers a wide range of topics simulation, modeling,
Since 1992, when it began as the "Medicine Meets Virtual Reality" conference, NextMed/MMVR has been a forum for researchers utilizing IT advances to improve diagnosis and therapy, medical education, and procedural training. Scientists and engineers, physicians and other care providers, educators and students, military medicine specialists, futurists, and industry: all come together with the shared goal of making healthcare more precise and effective. This book presents the proceedings of the 20th NextMed/MMVR conference, held in San Diego, California, USA, in February 2013. It covers a wide range of topics: simulation, modeling, imaging, data visualization, haptics, robotics, sensors, interfaces, plasma medicine, and more. Key applications include simulator design, information-guided therapies, learning tools, mental and physical rehabilitation, and intelligence networking. During the past two decades, healthcare has been transformed by progress in computer-enabled technology, and NextMed/MMVR has played a prominent role in this transformation.
This title covers a wide range of topics relevant to the development of drugs. It provides a comprehensive description of the major methodological strategies available for rational drug discovery.
Since the debut of the Medicine Meets Virtual Reality (MMVR) conference in 1992, MMVR has served as a forum for researchers harnessing IT advances for the benefit of patient diagnosis and care, medical education and procedural training. At MMVR, virtual reality becomes a theatre for medicine, where multiple senses are engaged - sight, sound and touch - and language and image fuse. Precisely because this theatre is unreal, it is a valuable tool: the risks of experimentation and failure are gone, while the opportunity to understand remains. Improvement of this tool, through steady technological progress, is the purpose of MMVR. This book presents papers delivered at the MMVR18 / NextMed conference, held in Newport Beach, California, in February 2011, with contributions from international researchers whose work creates new devices and methods at the juncture of informatics and medicine. Subjects covered include simulation and learning, visualization and information-guided therapy, robotics and haptics, virtual reality and advanced ICT in Europe, validation of new surgical techniques, and many other applications of virtual-reality technology. As its name suggests, the NextMed conference looks forward to the expanding role that virtual reality can play in global healthcare. This overview of current technology will interest those who dedicate themselves to improving medicine through technology.
These proceedings deal with the fundamentals and applications of poromechanics to geomechanics, material sciences, geophysics, acoustics and biomechanics. They discuss the state of the art in such topics as constitutive modelling and upscaling methods.
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a
This book covers the basic structural, thermodynamic and kinetic principles are covered and molecular strategies for the adaptation to high temperatures revealed by structure analysis are delineated. The roles of fluctuations, hydration and internal packing are thoroughly dicussed. Enzymes with a particular industrial importance, the subtilisin-like serine proteases, have been extensively studied by protein engineering. One extensive chapter is devoted to the present state of knowledge concerning structure-function relations and the origin of the their structural stability. Last but not least, computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or 3D structures are present