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Ten years ago a symposium on Cytotaxonomy 'was held in London (Proc. Linn. Soc. Lond. 169:110, 1958) in which a first attempt was made to bring together various disciplines to discuss advances of mammalian cytogenetics and to put them into proper context with the sciences of evolution and taxonomy. The introductory remarks by \V. B. Turrill to that symposium, essentially an admonishment to be tolerant of the short comings of our respective disciplines, would be a most appropriate begin ning to this conference as ,,'ell. However, the meeting held at Hanover was conceived more along the lines of remarks made by R. B. Seymour Se,,'ell in his presidential address to the same society: "It has been said that scientists in this search for truth are nowadays too much concerned with the accumulation of facts, and make too little use of their imagina tion in their attempts to explain such facts as they have accumulated. " (In "The continental drift theory and the distribution of the Copepoda," ibid. 166:149, 1956. ) \\Tith this as a background, two years ago we held the first of a series of loosely-structured conferences on reproductive failure in the relaxing atmosphere of this small New England college community. The manu scripts of that meeting have been published (Comparative Aspects of Re productive Failure, Springer-Verlag New York Inc. , 1967).
This book is intended for the senior undergraduate (Honours student) in genetics, and for the postgraduate who wants a survey of the whole field or information on a special area within it. In order to cater for readers with such different requirements, I have made the list of references unusually large for a textbook. It includes classical papers as well as very recent ones (to the end of 1974); reviews as well as specialized articles; elementary expositions from Scientific American as well as highly technical papers from journals on genetics and molecular biology. In areas of active research, I have given preference to the latest references, which will lead the reader to earlier ones. In addition to the references at the end of each chapter, a bibliography at the end of the book lists relevant books and general reviews. Apart from the first chapter, the book is not written as a history of mutation research; but throughout I have tried to emphasize the continuity of the problems, concepts and ideas. The reader will find many examples of this. Muller's once famous and then almost forgotten classification of genes by their action has now been given biochemical reality by studies of gene action in vitro. The problem of whether mutations can arise in non-replicating genomes is one of the oldest in mutation research; yet an unequivocal solution was obtained only recently with bacteriophage.
From prehistoric times man has had a pecial s relationship with seed plants - as a source of food, materials for tools, buildings, clothing and pharmaceuticals, and for ornamenting his surroundings for his own delight (probably in that chronological order which, incidentally, also gives some indication ofthe priorities oflife). Today man's most important staple foods are derived directly from seeds as they have been since neolithic times. (It is a sobering thought, as Harlan* has pointed out, that nothing significant has been added to his diet since then. ) From those times he must have learned to collect, conserve and cultivate seeds; and the accumulated experience has been handed down. This book then is part of an ancient tradition, for here we are still primarily concerned with these skills. Seeds are plant propagules comprised of embryos in which growth has been suspended, usually supplied with their own food reserves and protected by special covering layers. Typically they are relatively dry structures compared with other plant tissues and, in this condi tion) they are resistant to the ravages of time and their environment. But resistant is a relative tenn and seeds do deteriorate: the type, the extent and the rapidity of the deterioration, and the factors which control it are important to agronomists, horticulturalists, plant breeders, seedsmen, seed analysts, and those concerned with the conservation of genetic resources.
The Causes and Consequences of Chromosomal Aberrations explores one of the most dramatic examples of genomic instability-chromosomal aberrations. It describes some of the more recent techniques used to map genes within the human genome, study chromosomal aberrations at the cellular level, and define the organization of the interphase nucleus. General overviews are provided to build a conceptual framework for understanding the generality and specificity of chromosomal aberrations. The Causes and Consequences of Chromosomal Aberrations also explores the role of recombinases and topoisomerases in the development of chromosomal aberrations. It contains studies of chromosomal aberrations, which offer separate instructive treatises on specific malignancies. The Causes and Consequences of Chromosomal Aberrations is useful to medical and graduate students, physicians, molecular biologists, and cytogeneticists. It will benefit anyone interested in the concepts, contributions, and development in the field of molecular cytogenetics.