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These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.
Neurocognitive Mechanisms of Attention: Computational Models, Physiology, and Disease States describes the brain mechanisms underlying the attention control system, how those mechanisms are examined, how they operate in different disease states, and methods for improving them. Conceptual models of attention further explore their functional operation. Coverage includes the different types of attention, processing paths, brain anatomy, and attention's role in memory and movement. Factors affecting attention are explored including nutrition, exercise, and genetics. Neurocognitive disorders impacting attention are discussed including autism, ADHD, OCD, depression, anxiety, schizophrenia, Alzheimer's and Parkinson's Disease. Assessment methods and treatments are uniquely set against the backdrop of current conceptual, computational, and oscillatory-based models to encourage researchers to pursue continued development of new diagnostic and therapeutic tools. - Examines brain mechanisms underlying different types of attention - Explores how nutrition, exercise, genetics and more impact attention - Identifies impact on attention of neurocognitive diseases and disorders - Includes therapeutic advances to improve attention - Provides computational models via companion website
• . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . •. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.
This book sums up key research findings, and theoretical and technological advances having a direct bearing on neuroergonomics. Neuroergonomics is an emerging area whose Neuroergonomics is an emerging area that is collectively defined as the study of human brain function and behaviour in relation to behavioural performance in natural environments and everyday settings. It helps readers to understand neural mechanisms of human cognition in the context of human interaction with complex systems, as well as understanding the change of perception, decision-making and training in humans. The authors give new insights into augmenting human performance, reflecting upon the opportunities provided through neuroergonomics research and development. Computer systems acting on data from behavioural-output, physiological, and neurological sensing technologies are used to determine the user’s cognitive state and adapt the systems to change, support, and monitor human cognition. Various domains and case studies delve into the field of neuroergonomics in detail. These include, but are not limited to: an evaluation of technologies in health, workplace, and education settings, to show the different impacts of neuroergonomics in everyday lives; assessment of real-time cognitive measures; dynamic casual interactions between inhibition and updating functions, through analysis of behavioral, neurophysiological and effective connectivity metrics; and applications in human performance modelling and assessment of mental workload, showing the reader how to train and improve working memory capacity. Neuroergonomics: Principles and Practice provides academic practitioners and graduate students with a single go-to handbook that will be of significant assistance in research associated with human factors and ergonomics, human-computer interaction, human-systems engineering and cognitive neuroscience.
Remarkable advances in medical diagnostic imaging have been made during the past few decades. The development of new imaging techniques and continuous improvements in the display of digital images have opened new horizons in the study of brain anatomy and pathology. The field of brain imaging has now become a fast-moving, demanding and exciting multidisciplinary activity. I hope that this textbook will be useful to students and clinicians in the field of neuroscience, in understanding the fundamentals of advances in brain imaging.
Neuroimaging provides a valuable noninvasive window into the human neural system and is used in fundamental and clinical research. Imaging techniques are essential for understanding spontaneous neural activity and brain mechanisms engaged in the processing of external inputs, memory formation, and cognition. Modern imaging modalities make it possible to visualize memory processes within the brain and to create images of its structure and function. Scientists and technologists are joining forces to pave the way for improving imaging technologies and methods, data analysis, and the application of imaging to investigate the wide spectra of neurological diseases, neuropsychological disorders, and aging. Imaging techniques are essential for the identification of biological markers of the earliest stages of neurodiseases and the development of new therapies. This book intends to provide the reader with a short overview of the current achievements in the state-of-the-art imaging modality methods, their highlights, and limitations in neuroscience research and clinical applications. The current state of in-vivo neuroimaging methods in the context of the understanding and diagnosis of mental disorders and relation to the mind is also discussed in a modern compact format, featuring the latest and most relevant research results.
Image-Guided Neurosurgery provides readers with an update on the revolutionary improvements in imaging and visualization relating to neurosurgery. From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes. The book provides a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques discussed include brain biopsies, brain tumor resection, deep brain stimulation, and more. The book is ideal for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering. - A comprehensive reference on image-guided neurosurgery - Includes coverage of neuronavigation in cranial surgery and advanced imaging, including functional imaging, adoption of intra-operative MRI and emerging technologies - Covers all image-guided neurosurgery tools, including robotic surgical devices - Ideal reference for topics relating to neurosurgery, imaging, stereotaxis, radiosurgery, radiology, epilepsy, MRI, the use of medical robotics, lasers, and more
Balance, Gait, and Falls, Volume 159 presents the latest information on sensorimotor anatomy, sensory integration, gravity and verticality, standing balance, balance perturbations, voluntary stepping and gait initiation, gait and gait adaptability, disorders of balance and gait that result from aging and neurological diseases. The book provides a brief overview of age-related changes in the structure and function of sensorimotor and central processes, with sections specifically devoted to Parkinson's disease, parkinsonism, cerebellar ataxia, stroke, corticobasal degeneration, multiple sclerosis, Huntington's disease, dystonia, tremor, Alzheimer's disease, frontotemporal dementia, cerebral palsy, polio, motor neuron disease, brainstem lesions, spinal lesions, peripheral nerve disease, and psychogenic conditions. Diseases covered have a common structure comprising background and epidemiology, pathology, balance disorders, gait disorders, falls, therapies (including fall prevention), and future directions. - Covers all aspects of basic and clinical research on disorders of balance and gait in neurological disease - Presents a multidisciplinary review of balance and gait physiology, the epidemiology and natural history of balance and gait impairments in aging, and a broad range of neurological diseases - Addresses impairments of balance and gait for basic and clinical researchers in neuroscience, human movement science, physiotherapy and exercise physiology
Here you'll find more than 500 entries from the world's leading experts in the field on the basic concepts, methodologies, and applications in clinical trials. The range of topics includes: basic statistical concepts, design and analysis of clinical trials, ethics, regulatory issues, and methodologies for clinical data management and analysis