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We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Calcium and Phosphorus Metabolism focuses on the metabolism of calcium and inorganic phosphorus and covers topics ranging from the mechanism of calcium and phosphorus absorption in the intestine to calcium and phosphorus balances and retention. The results of balance experiments on the intestinal absorption of calcium and phosphorus are also presented. This book is comprised of 15 chapters and begins with an introduction to dietary sources of calcium and phosphorus, including water. The influence of vitamin D on the mechanism of calcium and phosphorus absorption in the intestine is then examined, along with calcium and phosphorus content of the body; recommended daily calcium and phosphorus requirements; calcium and phosphorus in the blood; and bone formation and resorption. The remaining chapters explore the chemical and organic composition of bone, together with theories of mineralization and the action of endocrine glands on bone as well as calcium and phosphorus metabolism. The final chapter is devoted to the metabolism of calcium and phosphorus in the teeth. This monograph will serve as a useful guide for biochemists and physiologists.
Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. - Provides a fully-updated resource with more color illustrations - Focuses on the biochemical and molecular basis of disease as well as the analytical techniques - Defines important differences in the pathophysiology of diseases, comparing childhood with adult
Calcium and Phosphorus in Health and Disease is a valuable source of information on the role of nutrition in maintaining bone health throughout the life cycle. It emphasizes nutritional interactions with mineral metabolism and maintenance of bone health. This book presents the basic concepts of regulation of calcium and phosphorus metabolism by calcemic hormones and the structure and function of calcified tissues. It provides an in-depth review of bone growth and maintenance and calcium metabolism throughout the life cycle. Pregnancy and lactation, the effects of physical activity, and the special problems of nutrition and bone health in the elderly are addressed. It presents the basic biochemistry of mineral homeostasis and bone development and presents reviews by experts on the treatment and epidemiology of osteoporosis. This text/reference is extensively illustrated, with numerous original drawings created especially for this work. Calcium and Phosphorus in Health and Disease will benefit both students in medical and basic sciences who are beginning their studies in this area and researchers and clinicians who are not expert in this field but need a source of basic information on the subject. The book's current discussions and up-to-date references will quickly move the beginning student to a higher level of understanding.
EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.
Acid-Base and Electrolyte Handbook for Veterinary Technicians provides an easy to understand yet comprehensive approach to acid-base and electrolyte balance. Covers the physiology of fluids and their effect on acid-base and electrolyte balance Offers detailed information on managing acid-base and electrolyte derangements in disease Includes access to a companion website with case studies and multiple choice questions
This book contains 10 chapters that discuss phosphorus and calcium metabolism, efficiency of utilization, availability, requirements and excretion in livestock and environmental impact.
Nutrition and Osteoporosis: Seeing Through a Glass, Darkly (1 Cor. 13:12) This volume of Advances in Nutritional Research deals with the present state of knowledge relative to the role of nutrition in the etiology of osteoporosis, one of the most serious degenerative diseases in the aging population. As a back drop for subsequent chapters on specific nutrients, Chapter 1 provides a com prehensive account of the gain and loss of bone throughout the life cycle, with emphasis on the architectural changes in later life that predispose to osteoporotic bone fractures. Chapter 2 documents the occurrence of aging bone loss through out human archeological history and Chapter 3 extends this documentation to all non-human vertebrate species so far examined, including primates living in the wild. It is apparent that a progressive loss of bone tissue is a normal accompaniment of aging among higher vertebrates. Whether it is a cause of bone fractures in animals, as it is in humans, is still unknown. It has also been established that there are significant differences in the frequency of osteoporotic fractures among human families, ethnic groups, national populations and diet cultures. Numerous studies have been carried out in an effort to explain these differences, and many of these deal with the possible effect of nutrition. Protracted controversies over the role of nutrition in the etiology of osteoporosis are reflected in the contents of several of the ensuing chapters.
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.