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Breast Cancer

Israel) International Association for Breast Cancer Research Conference (1989 : Tel Aviv

Published: 1989

Total Pages: 239


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Proceedings of the International Association for Breast-Cancer Research Conference, Tel-Aviv, Isreal, March 1989
In breast cancer as in other cancers on the front line of modern interdisciplinary research we have crossed the threshhold of new understanding. Fueled by an awareness that breast cancer is a leading cause of morbidity and mortality in women and honed by rapid technological advances in molecular mechanisms, major inroads into the darkness of this scourge have been accomplished during the past several years. Basic laboratory and clinical research findings must influence and in turn be influenced by efforts to detect, to diagnose and to cure the human disease. It is indeed gratifying to note that the efforts of scientists and clinicians from throughout the world reported in this volume are achieving this objective. The first section of the book focuses on the molecular and genetic basis of breast cancer. The role of specific oncogenes in mammary tumorigenesis using transgenic mice and mammary glands correlating molecular events with specific stages in neoplastic development are described and discussed. Such topics as the nature of specific oncogenes, levels of oncogene expression, the alteration of expression of other growth regulatory genes and the state of the cell in which the oncogene is expressed are specifically addressed. This section of the book is rounded out with discussions on the potential of genetic alterations as indicators of prognosis, the characterization of full-length cDNA codes for breast cancer markers and the function of antigens in tuomorigenesis.
Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
The optimal management of breast cancer patients relies on the expertise of a team of medical specialists including radiologists, surgeons, radiation therapists and medical oncologists. Much of the progress in breast cancer management made over the last several years reflects the translation of observations made in the laboratory to the clinic. Critically evaluating the impact of new treatment approaches relies on a commitment to well-designed clinical trials. In this volume, Advances in Breast Cancer Management, a renowned group of breast cancer experts have been asked to provide their perspective on management issues that directly effect patients on a day-to-day basis. Dr. Melody Cobleigh discusses the consequences of estrogen deprivation and the ways of ameliorating secondary symptoms and the potential long-term morbidity. Drs. Haigh and Guiliano review the sentinel lymph node biopsy technique including results from their extensive experience. Dr. Abram Recht places into perspective the potential benefit of post-mastectomy radiotherapy and reviews recent trials that address this issue. Dr. Dennis Slamon takes from us from the laboratory to the clinic in explaining the development of Herceptin as a paradigm for therapy targeted to specific molecular characteristics of breast cancer tumor cells. Drs. Nieto, Shpall, Crump and Pritchard offer different perspectives on the future of high-dose chemotherapy with stem cell transplantation as a treatment for breast cancer patients. Drs.
This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Contributions from leading authors in the field of clinical and biological breast cancer research constitute these three chapters: predisposition to breast cancer, carcinogenesis, and early breast cancer screening and management; tumour biology and prognostic; and therapeutics aspects of breast cancer. 21st Meeting of the International Association for Breast Cancer Research, Paris, 1996.
Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.