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An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. This is because diseases such as Parkinson's and Alzheimer's do not exist in biology. Yet, hundreds of clinical trials around the world are examining the potential of single therapies in thousands of people sharing one of these labels. Compounding the problem, these therapies were developed on evidence from models that do not come close to capturing the complexity of these diseases in the affected humans. These practices must end. Brain Fables is a call to refocus on understanding living and aging to create the personalized treatments each affected individual desperately needs.
Chevalier (anthropology, Carlton U., Ottawa) begins a series of three non-technical volumes on connections between brain, sign, and mind, seeking answers at the intersection between neuropsychology, semiotics, and philosophy. Here he explores symbols ranging from western naming practices to botanical imageries appearing in Genesis, English poetry, and native Mexican mythology.Distributed in the US by CUP Services. Annotation copyrighted by Book News, Inc., Portland, OR
How does the brain control the rest of the body? How does it enable the senses, regulate speech, affect balance, and influence sleep and dreams? These 30 full-page illustrations to color help explain every aspect of the brain's big job, from communicating with the central nervous system to retaining memories.
How new biomedical technologies—from prenatal testing to gene-editing techniques—require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities—especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich—an award-winning poet and memoirist, and the father of a young woman with Down syndrome—delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on “three-parent IVF,” a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.
Despite originating more than two-and-a-half thousand years ago, Aesop's Fables are still passed on from parent to child, and are embedded in our collective consciousness. The morals we have learned from these tales continue to inform our judgements, but have the stories also informed how we regard their animal protagonists? If so, is there any truth behind the stereotypes? Are wolves deceptive villains? Are crows insightful geniuses? And could a tortoise really beat a hare in a race? In Aesop's Animals, zoologist Jo Wimpenny turns a critical eye to the fables to discover whether there is any scientific truth to Aesop's portrayal of the animal kingdom. She brings the tales into the twenty-first century, introducing the latest findings on some of the most fascinating branches of ethological research – the study of why animals do the things they do. In each chapter she interrogates a classic fable and a different topic – future planning, tool use, self-recognition, cooperation and deception – concluding with a verdict on the veracity of each fable's portrayal from a scientific perspective. By sifting fact from fiction in one of the most beloved texts of our culture, Aesop's Animals explores and challenges our preconceived notions about animals, the way they behave, and the roles we both play in our shared world.
With more than one in ten Americans -- and more than one in five families -- affected, the phenomenon of migraine is widely prevalent and often ignored or misdiagnosed. By his mid-forties, Andrew Levy's migraines were occasional reminders of a persistent illness that he'd wrestled with half his life, though he had not fully contemplated their physical and psychological influence on the individual, family, and society at large. Then in 2006 Levy was struck almost daily by a series of debilitating migraines that kept him essentially bedridden for months, imprisoned by pain and nausea that retreated only briefly in gentler afternoon light. When possible, Levy kept careful track of what triggered an onset -- the "thin, taut" pain from drinking a bourbon, the stabbing pulse brought on by a few too many M&M's -- and in luminous prose recounts his struggle to live with migraines, his meticulous attempts at calibrating his lifestyle to combat and avoid them, and most tellingly, the personal relationship a migraineur develops -- an almost Stockholm syndrome-like attachment -- with the indescribable pain, delirium, and hallucinations. Levy read about personalities and artists throughout history with migraine -- Alexander Pope, Nietzsche, Freud, Virginia Woolf, even Elvis -- and researched the treatments and medical advice available for migraine sufferers. He candidly describes his rehabilitation with the aid of prescription drugs and his eventual reemergence into the world, back to work and writing. An enthralling blend of memoir and provocative analysis, A Brain Wider Than the Sky offers rich insights into an illness whose effects are too often discounted and whose sufferers are too often overlooked.
New York Times bestseller • Winner of the Los Angeles Times Book Prize • One of the Washington Post's 10 Best Books of the Year “It’s no exaggeration to say that Behave is one of the best nonfiction books I’ve ever read.” —David P. Barash, The Wall Street Journal "It has my vote for science book of the year.” —Parul Sehgal, The New York Times "Immensely readable, often hilarious...Hands-down one of the best books I’ve read in years. I loved it." —Dina Temple-Raston, The Washington Post From the bestselling author of A Primate's Memoir and the forthcoming Determined: A Science of Life Without Free Will comes a landmark, genre-defining examination of human behavior and an answer to the question: Why do we do the things we do? Behave is one of the most dazzling tours d’horizon of the science of human behavior ever attempted. Moving across a range of disciplines, Sapolsky—a neuroscientist and primatologist—uncovers the hidden story of our actions. Undertaking some of our thorniest questions relating to tribalism and xenophobia, hierarchy and competition, and war and peace, Behave is a towering achievement—a majestic synthesis of cutting-edge research and a heroic exploration of why we ultimately do the things we do . . . for good and for ill.
In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.
The true story of the first case to reveal the relation between the brain and complex personality characteristics.
From the illustrator of the classic edition of Snow-White and the Seven Dwarfs On a ridge above the Kalihari, Lion naps, until Mouse bumbles into him, willy-nilly, startling him awake. After a show of teeth, Lion is softened by Mouse's pledge of loyalty and sets him free. When a cold moon brings a humbling lesson, Lion comes to recognize Mouse's keen skill, and deeper kindness. Mouse and Lion, Aesop's fabled duo, renew their ancient bond in this warm retelling by Rand Burkert, illuminated by the authentic natural detail of Nancy Ekholm Burkert's art.