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There are two types of brain tumours: primary brain tumours that originate in the brain and metastatic (secondary) brain tumours that originate from cancer cells that have migrated from other parts of the body. Primary brain cancer rarely spreads beyond the central nervous system, and death results from uncontrolled tumour growth within the limited space of the skull. Metastatic brain cancer indicates advanced disease and has a poor prognosis. Primary brain tumours can be cancerous or non-cancerous. Both types take up space in the brain and may cause serious symptoms (eg: vision or hearing loss) and complications (eg: stroke). All cancerous brain tumours are life threatening (malignant) because they have an aggressive and invasive nature. A non-cancerous primary brain tumour is life threatening when it compromises vital structures (eg: an artery). In the United States, the annual incidence of brain cancer generally is 15-20 cases per 100,000 people. Brain cancer is the leading cause of cancer-related death in patients younger than 35. This new book brings together the leading research in this dynamic area of research.
This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.
This book is a comprehensive and up-to-date compendium of all aspects of brain tumors in children. After introductory chapters on the epidemiology of brain tumors, the book will provide readers with state-of-the art chapters on the principals of radiation therapy, neurosurgery and neuroimaging. Subsequent chapters discuss the biology and treatment of specific types of brain tumors. The concluding chapters present critical information relevant to survivorship, neurocognitive and other late effects, and the global challenges to better diagnosis and treatment of brain tumors in children. This book is co-authored by experts in the treatment of pediatric brain tumors. All of the authors are internationally recognized authorities and they offer an evidence-based consensus on the biology and treatment of brain tumors. This handbook has far-reaching applicability to the clinical diagnosis and management of brain tumors in children and will prove valuable to specialists, generalists and trainees alike.
Intraoperative imaging technologies have taken an ever-increasing role in the daily practice of neurosurgeons and the increasing attention and interest necessitated international interaction and collaboration. The Intraoperative Imaging Society was formed in 2007. This book brings together highlights from the second meeting of the Intraoperative Imaging Society, which took place in Istanbul-Turkey from June 14 to 17, 2009. Included within the contents of the book is an overview of the emergence and development of the intraoperative imaging technology as well as a glimpse on where the technology is heading. This is followed by in detail coverage of intraoperative MRI technology and sections on intraoperative CT and ultrasonography. There are also sections on multimodality integration, intraoperative robotics and other intraoperative technologies. We believe that this book will provide an up-to date and comprehensive general overview of the current intraoperative imaging technology as well as detailed discussions on individual techniques and clinical results.
Video Atlas of Neurosurgery: Contemporary Tumor and Skull Base Surgery is a unique resource that consists of 40 procedural videos and a concise companion book to reinforce your understanding of the material. Dr. Alfredo Quiñones-Hinojosa brings together a group of outstanding faculty, residents, and fellows lead by Dr. Jordina Rincon-Torroella, who carefully designed, assembled, and edited each chapter. The videos are enhanced through the inclusion of intraoperative photos, anatomical dissections, outstanding anatomical drawings, and animations that detail key steps and provide the experience of viewing a real-time surgery. Whether consulted together or independently of each other, the video and print content deliver all of the expert knowledge you need for effectively planning and understanding tumor and skull base surgeries. - Step-by-step, state-of-the-art videos – 40 in total – are accessible through Expert Consult and narrated by Dr. Quiñones-Hinojosa. - Each video is around 10 minutes with a total running time of over 6 hours - Videos highlight key surgical anatomy, focusing special attention on the relationship between lesions and important landmarks. - Procedures are broken down step-by-step for easy overview and comprehension. - Covers advanced techniques such as: intraoperative brain mapping; intraoperative assessment of resection through iMRI; fluorescence imaging; brain stem mapping techniques; combined open-and-endoscopic approaches, cortical-subcortical stimulation in awake surgery; and more. - Dedicated neurosurgical artwork by Devon Stuart includes superb figures that depict the surgical neuroanatomy and approaches in a step-wise fashion. - Chapters are presented from the less complex, more common surgeries to the most complex and cutting-edge procedures that may require multidisciplinary approaches.
The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. - Discusses the importance of the hypothalamus in human growth and development - Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders - Includes metabolic and eating disorders - Identifies mechanisms of disease action and etiology - Provides best practice information for assessment and treatment
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Because of tremendous advancements in research, neurosurgical oncology has become increasingly complex, and it is imperative that physicians have scientific evidence to guide and defend their decision making as they strive to provide the best patient care. Controversies in Neuro-Oncology: Best Evidence Medicine for Brain Tumor Surgery, written by world-renowned experts, is a comprehensive guide that compiles, synthesizes, and summarizes the most relevant scientific literature available in neurosurgical oncology. It provides objective recommendations based on the data found in the literature, giving physicians the information they need to make fully informed treatment decisions. Key Features: An opening chapter, Introduction to Best Evidence Medicine, illustrates how the authors rate the viability of the data presented Authors discuss in detail commonly disputed topics specific to tumor type, such as the roles of surgery and gross total resection as well as radiosurgery options Expert recommendation boxes highlight "takeaways" for the reader Summary tables distill abundant scientific evidence and emphasize the main conclusions of published studies This book will be the go-to guide for all neurosurgeons, oncologists, and neurologists involved in the multidisciplinary care of patients with brain tumors.
Rehabilitation of a person with cancer of the brain and spinal cord requires individualized care by a team of specialists from time of initial diagnosis through active treatment, survivorship, and advanced stages of the disease. The purpose of this book is to provide useful information to assist these clinicians in the noble endeavor of rehabilitating individuals diagnosed and treated for cancer of the central nervous system with the goal of maximizing the level of function and quality of life. This book begins with a description of the cancer rehabilitation continuum of care, safety considerations, and functional outcomes. The section on brain cancer provides content on neurosurgical management, rehabilitation, cognitive deficits, communication, and swallowing impairments. The section on spinal cord cancer provides the reader with information on characteristics of spinal cord tumors, neurosurgical management, and rehabilitation. A chapter on rehabilitation of the child with brain and spinal cord cancer addresses the unique needs of this population. Pain and fatigue are very common concerns raised by persons with cancer of the central nervous system, and these topics are covered as well. The final chapter covers the equally important topic of the role of palliative rehabilitation in advanced cancer--page ix.