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Can blockades and occupations be catalysts for positive change in Canada's Aboriginal communities?
Since the 1970s, environmental blockades disrupting the exploitation and destruction of forests, rivers, and other biodiverse places have been one of the most attention-grabbing and contentious forms of political action. This book explores when, where, and why environmental blockading and its associated tactics first arose. The author explores a broad range of questions, including how did tactics and practices first developed and popularised during environmental blockades come to feature regularly in animal rights, peace, refugee, and other campaigns? What are blockaders hoping to achieve? How have such blockades and tactics shaped government policy, the culture of modern politics, and popular understandings of ecology, colonialism, and activism? This book offers the first comprehensive history and analysis of environmental blockading in three key countries: Australia, the United States, and Canada. As the first places to experience sustained protest cycles which fully established, promoted, and developed the environmental blockading repertoire as an ongoing strategic option for movements nationally and internationally, these campaigns were central in creating a new approach to conservation issues. They also played a leading role in making obstructive direct action a regular part of political campaigning, as seen in the form of the Extinction Rebellion (XR), alter-globalisation, climate justice, and other movements. This book draws on rigorous archival research including sources ranging from personal diaries, campaign minutes, and video footage through to police reports and newspaper articles, as well as interviews with more than 30 protest leaders and campaigners. It will be of great interest to students and scholars in the fields of sociology, political science, history, green criminology, and interdisciplinary environmental studies.
Blockades have become a common response to Canada's failure to address and resolve the legitimate claims of First Nations. Blockades or Breakthroughs? debates the importance and effectiveness of blockades and occupations as political and diplomatic tools for Aboriginal people. The adoption of direct action tactics like blockades and occupations is predicated on the idea that something drastic is needed for Aboriginal groups to break an unfavourable status quo, overcome structural barriers, and achieve their goals. But are blockades actually "breakthroughs"? What are the objectives of Aboriginal people and communities who adopt this approach? How can the success of these methods be measured? This collection offers an in-depth survey of occupations, blockades, and their legacies, from 1968 to the present. Individual case studies situate specific blockades and conflicts in historical context, examine each group’s reasons for occupation, and analyze the media labels and frames applied to both Aboriginal and state responses. Direct action tactics remain a powerful political tool for First Nations in Canada. The authors of Blockades or Breakthroughs? Argue that blockades and occupations are instrumental, symbolic, and complex events that demand equally multifaceted responses. Contributors include Yale D. Belanger, Tom Flanagan, Sarah King, P. Whitney Lackenbauer, David Rossiter, John Sandlos, Nick Shrubsole, and Timothy Winegard.
Simpson uses Michi Saagiig Nishnaabeg storytelling to deepen our understanding of Indigenous resistance.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
This book provides an understanding of the Aboriginal resistence movement and the armed occupation at Oka. Part one focuses on the experiences of participants, both Aboriginal and non-Aboriginal, in the Temagami blockades in 1988-89 as well as to a lesser degree, in Oka in 1990. Part Two reviews themes of resistance in their historical context, and examples from the nineteenth and twentieth centuries are analyzed to develop those themes. Part three analyzes contemporary aspects of resistence, including resistence in the justice system, the courts and Aboriginal title, education and literature.
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.