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Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems. - Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers - Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications - Offers an insight into how to develop cost-effective diagnostics for early detection of cancer
Bridging the gap between research and clinical application, Biosensors and Molecular Technologies for Cancer Diagnostics explores the use of biosensors as effective alternatives to the current standard methods in cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer as well as the basic elements
Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. * Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins * Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research * Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.
Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnostics Particular focus on biosensors for cancer Summarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.
Biomedical sensors are an essential tool in the detection and monitoring of a wide range of medical conditions from cancer to Parkinson's disease. Biosensors for medical applications provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications.Part one focuses on key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors. Impedence interrogated affinity biosensors for medical applications and practical applications of enzyme biosensors are explored, before part two goes on to review specific medical applications. Biosensors for DNA and RNA detection and characterization, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors are investigated, along with biosensors for drug testing and discovery, non-invasive measurements, and wearable biosensors for medical applications.With its distinguished editor and international team of expert contributors, Biosensors for medical applications is an essential guide for all those involved in the research, design, production and use of medical biosensors. - Provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications - Examines key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors - Reviews biosensors for DNA and RNA detection and characterisation, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors
This new volume in the WHO series on histological and genetic typing of human tumors covers tumors of the kidney, the urinary system, the prostate, the testis and paratesticular tissue and the penis. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. This book is an authoritative, concise reference, prepared by 131 authors from 22 countries. It contains more than 800 color photographs, numerous MRIs, ultrasound images, CT scans, charts and 3000 references.This book is in the series commonly referred to as the "Blue Book" series."Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs"Contributors:: Dr Lauri A. Aaltonen, Dr Ferran Algaba, Dr William C. Allsbrook Jr., Dr Isabel Alvarado-Cabrero, Dr Mahul B. Amin, Dr Pedram Argani, Dr Hans Arnholdt, Dr Alberto G. Ayala, Dr Sheldon Bastacky, Dr Louis R. Begin, Dr Athanase Billis, Dr Liliane Boccon-Gibod, Dr Stephen M. Bonsib, Dr Christer Busch, Dr Paul Cairns, Dr Liang Cheng, Dr John Cheville, Dr Carlos Cordon-Cardo, Dr Antonio L. Cubilla, Dr Ivan Damjanov, Dr Charles J. Davis, Dr Angelo M. De Marzo, Dr Louis P. Dehner, Dr Brett Delahunt, Dr Gonzague De Pinieux, Dr P. Anthony Di Sant agnese, Dr Joakim Dillner, Dr John N. Eble, Dr Diana M. Eccles, Dr Lars Egevad, Dr M.N. El-Bolkainy, Dr Jonathan I. Epstein, Dr John F. Fetsch, Dr Masakuni Furusato, Dr Thomas Gasser, Dr William L. Gerald, Dr A. Geurts Van Kessel, Dr David J. Grignon, Dr Kenneth Grigor, Dr Jay L. Grosfeld, Dr Louis Guillou Dr Seife Hailemariam, Professor Ulrike Maria Hamper, Dr Arndt Hartmann, Dr Tadashi Hasegawa, Dr Axel Heidenreich, Dr Philipp U. Heitz, Dr Burkhard Helpap, Dr Riitta Herva, Professor Ferdinand Hofstadter, Professor Simon Horenblas, Dr Peter A. Humphrey, Dr Kenneth A. Iczkowski, Dr Grete Krag Jacobsen, Dr Sonny L. Johansson, Dr Michael A. Jones, Dr Peter A. Jones, Dr George W. Kaplan, Dr Charles E. Keen, Dr Kyu Rae Kim, Dr Maija Kiuru, Dr Paul Kleihues, Dr Margaret A. Knowles, Dr Gyula Kovacs, Dr Marc Ladanyi, Dr Virpi Launonen, Dr Ivo Leuschner, Dr Howard S. Levin, Dr W. Marston Linehan, Dr Leendert H.J. Looijenga, Dr Antonio Lopez-Beltran, Dr J. Carlos Manivel, Dr Guido Martignoni, Dr Alexander Marx, Dr David G. Mcleod, Dr L. Jeffrey Medeiros, Dr Maria J. Merino, Dr Helen Michael, Dr Markku Miettinen, Dr Holger Moch, Dr Henrik Moller, Dr Rodolfo Montironi, Dr F. Kash Mostofi, Dr Hartmut P.H. Neumann, Dr Manuel Nistal, Dr Lucien Nochomovitz, Dr Esther Oliva, Dr Tim D. Oliver, Dr J. Wolter Oosterhuis, Dr Attilio Orazi, Dr Chin-Chen Pan, Dr Ricardo Paniagua, Dr David M. Parham, Dr D. Max Parkin, Dr M. Constance Parkinson, Dr Christian P. Pavlovich, Dr Elizabeth J. Perlman, Dr Paola Pisani, Dr Andrew A. Renshaw, Dr Victor E. Reuter, Dr Jae Y. Ro, Professor Mark A. Rubin, Dr H. Gil Rushton, Dr Wael A. Sakr, Dr Hemamali Samaratunga, Dr Guido Sauter, Dr Paul F. Schellhammer, Dr Bernd J. Schmitz-Drager, Dr Mark Philip Schoenberg, Dr Isabell A. Sesterhenn, Dr David Sidransky, Dr Ronald Simon, Dr Leslie H. Sobin, Dr Poul H. B. Sorensen, Dr John R. Srigley, Dr Stephan Storkel, Dr Aleksander Talerman, Dr Pheroze Tamboli, Dr Puay H. Tan, Dr Bernard Tetu, Dr Kaori Togashi, Dr Lawrence True, Dr Jerzy E. Tyczynski, Dr Thomas M. Ulbright, Dr Eva Van Den Berg, Dr Theo H. Van Der Kwast, Dr Annick Vieillefond, Dr Geo Von Krogh, Dr Thomas Wheeler, Dr Paula J. Woodward, Dr Ximing J. Yang, Dr Berton Zbar"
This book presents recent research on cancer detection methods based on nanobiosensors, which offer ultrasensitive point-of-care diagnosis. Several methods for diagnosing cancer have been discovered and many more are currently being developed. Conventional clinical approaches to detecting cancers are based on a biopsy followed by histopathology, or on the use of biomarkers (protein levels or nucleic acid content). Biopsy is the most widely used technique; however, it is an invasive technique and is not always applicable. Furthermore, biomarker-based detection cannot be relied on when the biomarkers are present in an extremely low concentration in the body fluids and in malignant tissues. Thus, in recent years highly sensitive and robust new cancer diagnosis techniques have been developed for clinical application, and may offer an alternative strategy for cancer diagnosis. As such, this book gathers the latest point-of-care cancer diagnostic methods and protocols based on biomedical sensors, microfluidics, and integrated systems engineering. It also discusses recent developments and diagnostics tests that can be conducted outside the laboratory in remote areas. These technologies include electrochemical sensors, paper-based microfluidics, and other kit-based diagnostic methods that can be adapted to bring cancer detection and diagnostics to more remote settings around the globe. Overall, the book provides students, researchers, and clinicians alike a comprehensive overview of interdisciplinary approaches to cancer diagnosis.
Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. - Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications - Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications - Includes contributions from leading international researchers with extensive experience in developing medical biosensors - Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care
The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.