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Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. - Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences - Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics - Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology
This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Nomenclature -- 1: Introduction -- References -- 2: Rates, Rate Constants, and Order -- I. Order -- II. Rates and Rate Constants -- 3: Active and Passive Transport -- I. Introduction -- II. Passive Transport -- III. Active Transport -- References -- 4: Pharmacokinetics -- I. Introduction -- II. Drug Disposition -- III. Constant-Rate Intravenous Infusion -- IV. Compartmental Models and Their Limitations -- V. Absorption Rate Constants -- References -- 5: Biopharmaccutics -- I. Extravascular Administration -- II. Absorption of Drugs from the Gastrointestinal Tract -- III. Factors Influencing Bioavailability -- IV. Evaluation of the Bioavailability of a Single Drug -- V. Drug Delivery to Prolong Duration -- References -- 6: Dosage Regimens -- I. Introduction -- II. Accumulation During Repetitive Dosing -- III. Adjustment of Dosage Regimen in Renal Failure -- IV. Multiple Dosing of Constant-Rate Intravenous Infusions -- References -- 7: Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy -- I. Introduction -- II. Antimicrobial Agents -- III. Pharmacokinetics of Prodrugs -- IV. Stereoisomers -- References -- 8: Pharmacokinetic Applications in Clinical Practice -- I. Introduction -- II. Pharmacokinetic Drug Interactions -- III. Clinical Pharmacokinetics -- References -- Appendix -- Index
This book deals with the basics of the two disciplines of biopharmaceutics and pharmacokinetics. Different factors such as biological, physiochemical and formulation that influence the therapeutic efficacy of a drug are covered in biopharmaceutics. The absorption, distribution, metabolism and excretion of drugs are studied under this subject. Salient Features - Basics of biopharmaceutics and pharmacokinetics help to understand the various procedures and advances in drug design, product development, therapeutic drug monitoring, etc. - Pharmacokinetics covers the fundamentals of one compartment open model, multi-compartmental models. One compartment open model is presented in an elaborate manner to make the students familiar with various aspects of pharmacokinetics - Mathematical equations are developed using simple integration and differentiation methods - Practice problems are provided wherever necessary, and a question bank is included at the end of each chapter - Extreme care has been exercised to present the concepts in a simple way Second Edition includes - Application of principles in formulation development in industry for successful bioequivalence studies is included - One chapter on "In-vitro Dissolution Testing" is included to evaluate test formulations to chose right product for bioequivalence studies - A chapter on biostatistics with practice problems is included
Essentials of Biopharmaceutics and Pharmacokinetics Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically. The book interrelates five different sections: Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? Section 2 Biopharmaceutics Section 3 Pharmacokinetics Section 4 Clinical Pharmacokinetics Section 5 Bioavailability and Bioequivalence Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics. Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.
The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.