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Biomineralization is a natural process by which living organisms form minerals in association with organic biostructures to form hybrid biological materials such as bone, enamel, dentine and nacre among others. Scientists have researched the fundamentals of these processes and the unique structures and properties of the resulting mineralized tissues. Inspired by them, new biomaterials for tissue engineering and regenerative medicine have been developed in recent years. Biomineralization and biomaterials: fundamentals and applications looks at the characteristics of these essential processes and natural materials and describes strategies and technologies to biomimetically design and produce biomaterials with improved biological performance. - Provides a thorough overview of the biomineralization process - Presents the most recent information on the natural process by which crystals in tissues form into inorganic structures such as bone, teeth, and other natural mineralized tissues - Investigates methods for improving mineralization - Explores new techniques that will help improve the biomimetic process
This first comprehensive overview of the modern aspects of biomineralization represents life and materials science at its best: Bioinspired pathways are the hot topics in many disciplines and this holds especially true for biomineralization. Here, the editors -- well-known members of associations and prestigious institutes -- have assembled an international team of renowned authors to provide first-hand research results. This second volume deals with biometic model systems in biomineralization, including the biomineral approach to bionics, bioinspired materials synthesis and bio-supported materials chemistry, encapsulation and the imaging of internal nanostructures of biominerals. An interdisciplinary must-have account, for biochemists, bioinorganic chemists, lecturers in chemistry and biochemistry, materials scientists, biologists, and solid state physicists.
This volume provides a comprehensive academic review of both positive and negative effects of minerals on human health and quality of life. The book adopts the concept of mineral latu sensu (mineral l.s.), which encompasses a broad spectrum of natural, inorganic, solid, and crystalline, of natural and inorganic chemical elements (metals and metalloids), of modified natural minerals, of biominerals, and of syntetic minerals, all products that branch across the disciplines of earth, soil, environmental, materials, nutrition, and health sciences. Using this broad framework, the authors are able to provide a multidisciplinary assessment on many types of minerals which can be essential, beneficial and hazardous to human health, covering applications in medical geology, medical hydrology or balneotherapy, pharmacology, chemistry, nutrition, and biophysics. The book performs historical analyses of the uses of minerals for therapeutic and cosmetic purposes to better understand current trends and developments in mineral research and human health. The book will be of interest to students, public health officials, environmental agencies and researchers from various disciplines, as well as scientific societies and organizations focusing on medical geology, health resort medicine (crenotherapy, hydrotherapy and climatotherapy), and on pharmaceutical, cosmetic and biomedical applications.
Bioactive materials, or biomaterials, have the ability to interact biologically with the tissue to which it is inserted, and to stimulate the deposition of mineralized tissue. The calcium phosphate-based ceramics were the first known materials in dentistry to have bioactivity, and currently, these materials are the most used for biomedical purposes, with different morphological characteristics. In dentistry, these materials have achieved immense importance by stimulating the deposition of osseous tissue in injured bone, and by having the ability to remineralize hard tooth tissues (enamel and dentin). Furthermore, repair materials based on aggregated trioxides mineral or on calcium hydroxide are classic biomaterials and widely used in dentistry, mainly in contact with the pulp tissue or periodontal ligament, for repair processes. However, various formulations of these materials appear all the time, in search of the ideal material. In general, bioactive materials have been shown to promote the release of calcium, sodium, silicon and phosphate ions, which are metabolized by the body, having effects such as angiogenesis and antimicrobial action, which can be improved depending on the composition of the material. Pulp tissue is a highly specialized dental tissue and is the subject of intense studies about the response to biomaterials. It is also understood that some systemic alterations in individuals have an influence on the action of bioactive materials during tissue repair processes. Thus, this book will address the use of different bioactive materials in dentistry, considering the performance of these biomaterials in the hard tissues of the tooth, and the response of the dental pulp, as well as the influence of the composition of these materials and of the individual's systemic alterations in bioactivity and in antimicrobial activity. The several in vivo and in vitro tests to evaluate the bioactivity of a biomaterial will also be addressed.
Biomineralization is a hot topic in the area of materials, and this volume in the Metals Ions in Life Sciences series takes a systematic approach, dealing with all aspects from the fundamentals to applications. Key biological features of biomineralization, such as gene directed growth and the role of enzymes are covered, as are new areas, including copper/zinc in the jaws of invertebrates or magnetic biomaterials that help birds with navigation
Takes a materials science approach, correlating structure-property relationships with function across a broad range of biological materials.
Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms.
Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated. With its distinguished editors and international team of contributors, Tissue Engineering using Ceramics and Polymers reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. Part one discusses general issues such as ceramic and polymeric biomaterials, scaffolds, transplantation of engineered cells, surface modification and drug delivery. Later chapters review characterisation using x-ray photoelectron spectroscopy and secondary ion mass spectrometry as well as environmental scanning electron microscopy and Raman micro-spectroscopy. Chapters in part two analyse bone regeneration and specific types of tissue engineering and repair such as cardiac, intervertebral disc, skin, kidney and bladder tissue. The book concludes with the coverage of themes such as nerve bioengineering and the micromechanics of hydroxyapatite-based biomaterials and tissue scaffolds. Tissue Engineering using Ceramics and Polymers is an innovative reference for professionals and academics involved in the field of tissue engineering. - An innovative and up-to-date reference for professionals and academics - Environmental scanning electron microscopy is discussed - Analyses bone regeneration and specific types of tisue engineering
Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. - Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties - Presents the clinical potential of octacalcium phosphate biomaterials - Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration