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There is growing interest in the use of physical plasmas (ionized gases) for biomedical applications, especially in the framework of so-called “plasma medicine”, which exploits the action of low-power, atmospheric pressure plasmas for therapeutic purposes. Such plasmas are “cold plasmas”, in the sense that only electrons have a high temperature, whereas ions and the neutral gas particles are at or near room temperature. As a consequence, the “plasma flame” can be directly applied to living matter without appreciable thermal load. Reactive chemical species, charged particles, visible and UV radiation, and electric fields are interaction channels of the plasma with pathogens, cells, and tissues, which can trigger a variety of different responses. Possible applications include disinfection, wound healing, cancer treatment, non-thermal blood coagulation, just to mention some. The understanding of the mechanisms of plasma action on living matter requires a strongly interdisciplinary approach, with competencies ranging from plasma physics and technology to chemistry, to biology and finally to medicine. This book is a collection of work that explores recent advances in this field.
Plasma can be defined as the extracellular matrix of blood cells. Plasma components, their role in human health risk evaluation, and their functional and clinical analyses are covered in this book. Furthermore, physical plasma-ionized gas is one of the four fundamental states of matter. This homonym has begun to emerge because it can interact with living systems. The physical plasma biomedical applications are reviewed in drug delivery and wound healing medical applications. This approach revolutionizes the therapeutic approaches in medicine and may open up new concepts and clinical applications. The book is an essential source for researchers in the field and provides a platform for different professions.
Cold atmospheric plasma (CAP) emerges as a possible new modality for cancer treatment. This book provides a comprehensive introduction into fundamentals of the CAP and plasma devices used in plasma medicine. An analysis of the mechanisms of plasma interaction with cancer and normal cells including description of possible mechanisms of plasma selectivity is included. Recent advances in the field, the primary challenges and future directions are presented.
Cold atmospheric plasma (CAP) generators have been actively developed as a new device for medical treatment. The applications of plasma treatment include 1) disinfection, sterilization, and decontamination, which inactivates or kills bacteria, fungi, viruses and spores; 2) bleeding control, which coagulates blood swiftly; 3) wound healing, which shortens the healing period and benefits the regeneration of the epithelization of tissue to avoid scar formation; etc.Biomedical applications of CAPs are explored via either in-vitro assays, or in-vivo tests using pigs as animal models; tests include sterilization of oral pathogens and biofilm, decontamination of biological warfare agent, blood clotting and rapid control of active life-threatening hemorrhage, and post-operative observation of wound healing after plasma treatment. The conventional approaches in each application are first introduced, then the advantages of plasma treatments are discussed and demonstrated by the test results. The mechanisms of CAPs' biocidal effect, blood clotting effect, and wound healing effect are presented and discussed.
This comprehensive text is suitable for researchers and graduate students of a ‘hot’ new topic in medical physics. Written by the world’s leading experts, this book aims to present recent developments in plasma medicine, both technological and scientific, reviewed in a fashion accessible to the highly interdisciplinary audience consisting of doctors, physicists, biologists, chemists and other scientists, university students and professors, engineers and medical practitioners. The book focuses on major topics and covers the physics required to develop novel plasma discharges relevant for medical applications, the medicine to apply the technology not only in-vitro but also in-vivo testing and the biology to understand complicated bio-chemical processes involved in plasma interaction with living tissues.
This book presents the state of the art in clinical plasma medicine and outlines translational research strategies. Written by an international group of authors, it is divided into four parts. Part I is a detailed introduction and includes basic and recent research information on plasma sciences, plasma devices and mechanisms of biological plasma effects. Parts II and III provide valuable clinical insights f.e. into the treatment of superficial contaminations, ulcerations, wounds, treatment of cells in cancer, special indications like in heart surgery, dentistry, palliative treatment in head and neck cancer or the use of plasma in hygiene. Part IV offers information on how and where to qualify in plasma medicine and which companies produce and supply medical devices and is thus of particular interest to medical practitioners. This comprehensive book offers a sciences based practical to the clinical use of plasma and includes an extended selection of scientific medical data and translational literature.
The first book dedicated exclusively to plasma medicine for graduate students and researchers in physics, engineering, biology, medicine and biochemistry.
Written by a team of pioneering scientists from around the world, Low Temperature Plasma Technology: Methods and Applications brings together recent technological advances and research in the rapidly growing field of low temperature plasmas. The book provides a comprehensive overview of related phenomena such as plasma bullets, plasma penetration into biofilms, discharge-mode transition of atmospheric pressure plasmas, and self-organization of microdischarges. It describes relevant technology and diagnostics, including nanosecond pulsed discharge, cavity ringdown spectroscopy, and laser-induced fluorescence measurement, and explores the increasing research on atmospheric pressure nonequilibrium plasma jets. The authors also discuss how low temperature plasmas are used in the synthesis of nanomaterials, environmental applications, the treatment of biomaterials, and plasma medicine. This book provides a balanced and thorough treatment of the core principles, novel technology and diagnostics, and state-of-the-art applications of low temperature plasmas. It is accessible to scientists and graduate students in low-pressure plasma physics, nanotechnology, plasma medicine, and materials science. The book is also suitable as an advanced reference for senior undergraduate students.
Cold Plasma in Food and Agriculture: Fundamentals and Applications is an essential reference offering a broad perspective on a new, exciting, and growing field for the food industry. Written for researchers, industry personnel, and students interested in nonthermal food technology, this reference will lay the groundwork of plasma physics, chemistry, and technology, and their biological applications. Food scientists and food engineers interested in understanding the theory and application of nonthermal plasma for food will find this book valuable because it provides a roadmap for future developments in this emerging field. This reference is also useful for biologists, chemists, and physicists who wish to understand the fundamentals of plasma physics, chemistry, and technology and their biological interactions through applying novel plasma sources to food and other sensitive biomaterials. - Examines the topic of cold plasma technology for food applications - Demonstrates state-of-the-art developments in plasma technology and potential solutions to improve food safety and quality - Presents a solid introduction for readers on the topics of plasma physics and chemistry that are required to understand biological applications for foods - Serves as a roadmap for future developments for food scientists, food engineers, and biologists, chemists, and physicists working in this emerging field
Atmospheric-pressure plasmas continue to attract considerable research interest due to their diverse applications, including high power lasers, opening switches, novel plasma processing applications and sputtering, EM absorbers and reflectors, remediation of gaseous pollutants, excimer lamps, and other noncoherent light sources. Atmospheric-pressure plasmas in air are of particular importance as they can be generated and maintained without vacuum enclosure and without any additional feed gases. Non-Equilibrium Air Plasmas at Atmospheric Pressure reviews recent advances and applications in the generation and maintenance of atmospheric-pressure plasmas. With contributions from leading international researchers, the coverage includes advances in atmospheric-pressure plasma source development, diagnostics and characterization, air plasma chemistry, modeling and computational techniques, and an assessment of the status and prospects of atmospheric-pressure air plasma applications. The extensive application sections make this book attractive for practitioners in many fields where technologies based on atmospheric-pressure air plasmas are emerging.