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Cytomechanics is the application of the classical principles of mechanics in cell biology. It is an applied science concerned with the description and evaluation of mechanical properties of cells and their organelles as well as of the forces exerted by them. Thus, this topic needs a truly interdisciplinary approach, and accordingly this volume gives an up-to-date account of the current research done on cell division, mitosis, cytokinesis, cell locomotion and cell deformation during normal development and the cytoskeletal role in cell shape. Biologists, biomechanicians, biophysicists, biochemists and biomathematicians here discuss the basic concepts of mechanics and thermodynamics, emphasizing their applicability to cell activities.
The NATO Advanced Study Institute on Biomechanics of Active Movement and Division of Cells was held September 19-29, 1993 in Istanbul and the Proceedings are presented in this volume. Sixty-eight scientists from sixteen countries attended. Prof. J. Bereiter-Hahn of Goethe-Universitat, Frankfurt, Germany, Prof. A.K. Harris of the University of North Carolina, Chapel Hill, USA, Prof. R.M. Nerem of Georgia Institute of Technology, Atlanta, USA and Prof. R. Skalak of the University of California, San Diego, USA were the members of the International Organizing Committee. As the Scientific Director of the Institute, I wish to express my sincere appreciation for their assistance without which the Institute could not have taken place. This Institute is the third one of the meetings which are now called "the NATO Istanbul Meetings on Cytomechanics". The first one was the NATO Advanced Research Workshop on Biomechanics of Cell Division which was held October 12-17, 1986 in Istanbul. The Proceedings were published as NATO ASI Series A Life Sciences Vol. 132 by Plenum Press in 1987. The second one was the NATO Advanced Study Institute on Biomechanics of Active Movement and Deformation of Cells which was held September 3-13, 1989 in Istanbul. The Proceedings were published as NATO ASI Series H : Cell Biology Vol. 42 by Springer-Verlag in 1990.
The NATO Advanced Study Institute on Biomechanics of Active Movement and Division of Cells was held September 19-29, 1993 in Istanbul and the Proceedings are presented in this volume. Sixty-eight scientists from sixteen countries attended. Prof. J. Bereiter-Hahn of Goethe-Universitat, Frankfurt, Germany, Prof. A.K. Harris of the University of North Carolina, Chapel Hill, USA, Prof. R.M. Nerem of Georgia Institute of Technology, Atlanta, USA and Prof. R. Skalak of the University of California, San Diego, USA were the members of the International Organizing Committee. As the Scientific Director of the Institute, I wish to express my sincere appreciation for their assistance without which the Institute could not have taken place. This Institute is the third one of the meetings which are now called "the NATO Istanbul Meetings on Cytomechanics". The first one was the NATO Advanced Research Workshop on Biomechanics of Cell Division which was held October 12-17, 1986 in Istanbul. The Proceedings were published as NATO ASI Series A Life Sciences Vol. 132 by Plenum Press in 1987. The second one was the NATO Advanced Study Institute on Biomechanics of Active Movement and Deformation of Cells which was held September 3-13, 1989 in Istanbul. The Proceedings were published as NATO ASI Series H : Cell Biology Vol. 42 by Springer-Verlag in 1990.
First multi-year cumulation covers six years: 1965-70.
Current Topics in Developmental Biology
Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.
The tendency of a living organism to move to a more favourable environment is a natural but complex reaction, involving the integration of sometimes conflicting environmental stimuli as well as a coordinated mechanical response. The response of motile, single cell organisms to environmental stimuli provides a useful model for understanding first of all how the environment is monitored and sensed, and secondly how this information is processed to result in an integrated and coordinated response. The volume looks at a large number of well-studied examples of the chemotactic response, in prokaryotes and eukaryotes, and casts new light on how cells process information and react to their environment. This fundamental response is of great importance in understanding one of the characteristic features of living organisms.
This 121st IMA volume, entitled MATHEMATICAL MODELS FOR BIOLOGICAL PATTERN FORMATION is the first of a new series called FRONTIERS IN APPLICATION OF MATHEMATICS. The FRONTIERS volumes are motivated by IMA pro grams and workshops, but are specially planned and written to provide an entree to and assessment of exciting new areas for the application of mathematical tools and analysis. The emphasis in FRONTIERS volumes is on surveys, exposition and outlook, to attract more mathematicians and other scientists to the study of these areas and to focus efforts on the most important issues, rather than papers on the most recent research results aimed at an audience of specialists. The present volume of peer-reviewed papers grew out of the 1998-99 IMA program on "Mathematics in Biology," in particular the Fall 1998 em phasis on "Theoretical Problems in Developmental Biology and Immunol ogy." During that period there were two workshops on Pattern Formation and Morphogenesis, organized by Professors Murray, Maini and Othmer. James Murray was one of the principal organizers for the entire year pro gram. I am very grateful to James Murray for providing an introduction, and to Philip Maini and Hans Othmer for their excellent work in planning and preparing this first FRONTIERS volume. I also take this opportunity to thank the National Science Foundation, whose financial support of the IMA made the Mathematics in Biology pro gram possible.
Recent years have seen a growing interest in and activity at the interface between physics and biology, with the realization that both subjects have a great deal to learn from and to teach to one another. A particularly promising aspect of this interface concerns the area of cooperative phenomena and phase transitions. The present book addresses both the structure and motion of biological materials and the increasingly complex behaviour that arises out of interactions in large systems, giving rise to self organization, adaptation, selection and evolution: concepts of interest not only to biology and living systems but also within condensed matter physics. The approach adopted by Physics of Biomaterials: Fluctuations, Self Assembly and Evolution is tutorial, but the book is fully up to date with the latest research. Written at a level appropriate to graduate researchers, preferably with a background either in condensed matter physics or theoretical or physically-oriented experimental biology.