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Experience with animals exposed in a variety of above and below ground structures during full-scale field operations at the Nevada Test Site in 1953, 1955 and 1957 were reviewed. The data were assembled and summarized to illustrate the nature of the blast-induced problems of significance in protective shelters, "open" as well as "closed". Potential hazards were related to the following: various patterns of variation in environmental pressure; translational events associated with transient, high-velocity winds, ground shock and gravity involving the impact of energized inanimate objects on the one hand the the consequences of whole-body displacement on the other; non-line-of-site thermal phenomena including hot objects and rapidly moving hot, dust- laden air and debris; and dust, in the respirable size range, sufficiently high in concentration even in "closed" shelters as to warrant design measures to minimize or eliminate the occurrence of small particulates whether arising from wall spalling or otherwise. Tentative biological criteria, conceived to help assess human hazards from blast-related phenomena, were presented. Relevant data from the literature and on- going research in environmental medicine were set forth to aid the reader in appreciating how the criteria were formulated, what information was extrapolated from animal data, and wherein "best estimates" were employed. "State-of-the-art" concepts were noted to emphasize areas in which more thinking and research must continue if more refined, complete and adequate criteria are to be forthcoming for assessing man's response to blast-induced variation in his immediate environment.
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
This book aims to help clinicians who seek to conduct science and engineering based research on blast injuries as well as engineers and scientists who seek to apply their expertise to address blast injuries. Blast injuries are prevalent. While the current conflict in Afghanistan is reaching its final stages, the legacy of landmines will sadly ensure that injuries and fatalities will continue to occur. The understanding of these injuries and the science behind their mitigation and treatment is a multi-disciplinary effort. Current knowledge has rapidly grown due to recent conflicts, yet the learning has not yet been captured in any formal way.
Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.