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The use of laser light for targeting devices and industry has dramatically increased the likelihood that personnel will be exposed to laser energy during military and commercial operations. The increased potential for exposure of humans to lasers highlights the need to understand laser-tissue interactions at the most basic cell and molecular levels. Current ultrashort pulse laser safety standards are based on a minimal visible lesion (MVL), i.e., histological, damage endpoint in the Rhesus monkey model (Shaver, 2001). A human model for assessing laser-light damage to tissue at the cell and molecular level is desirable for scientific, political and fiduciary reasons. This research assesses the effects of sublethal pulsed laser-light treatment to a human melanocyte (skin) cell line. Proteomic inquiry into the cellular effect of laser treatment was accomplished via parallel sample analysis with over 850 monoclonal antibodies in order to screen for changes in the levels of protein expression. In short, the data indicated dramatically increased molecular debridement, decreased apoptotic signaling and cell cycling and other cellular phenomena sufficient to propose a stress response and recovery paradigm.
This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.
A careful review of the literature covering various aspects of applications of lasers in science and technology reveals that lasers are being applied very widely throughout the entire gamut of physical medicine. After surveying the current developments taking place in the field of medical applications of lasers, it was considered appropriate to bring together these efforts of international research scientists and experts into one volume. It is with this aim that the editors have prepared this volume which brings current research and recent developments to the attention of a wide spectrum of readership associated with hospitals, medical institutions and universities world wide, including also the medical instrument industry. Both teachers and students in the medical faculties will especially find this compendium quite useful. This book is comprised of eleven chapters. All of the important medical applications of lasers are featured. The editors have made every effort that individual chapters are self-contained and written by experts. Emphasis has been placed on straight and simple presentation of the subject matter so that even the new entrants into the field will find the book of value.
The series “Clinical Approach and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume addresses the most important physical approaches in cosmetic dermatology, disclosing their uses and advantages. Here are discussed in detail the applicability of lasers and other lights, photodynamic therapy, radiofrequency, ultrasound and transepidermal drug delivery.
This book introduces modern directed-energy beam weaponry and emerging technical concepts based on unclassified and declassified information. The book covers laser systems, analyzing the interaction between high-power laser beams and matter, and examines penetration of high power beams such as microwave and scalar wave. It also covers the use of particle and high-power radar beams and scalar wave as weapons of the future. In-depth coverage of the relevant mathematical and engineering topics and concepts are included. The book will provide scientists and engineers with valuable guidance on the fundamentals needed to understand state-of-the-art directed energy weaponry technology research and applications. Provides guidance on the fundamentals of state-of-the-art directed-energy weaponry technology; Introduces the physics behind directed-energy weapons; Offers in-depth coverage of mathematical and engineering topics.