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Atopic dermatitis is a chronic inflammatory skin disease that is characterized by xerosis, eczema lesions with skin barrier defects, and severe itch. This compilation describes recent advances in our understanding of intractable itch mechanisms and the development of antipruritic therapies in in this condition. Additionally, the authors summarize the current developments in understanding the comorbidities of atopic dermatitis.Insight into various emerging therapies along with currently approved treatments is provided. Some proposed interventions are presented regarding the population group that can benefit the most according to the severity of the symptoms, the mechanism of action of the intervention and the possible adverse effects.The authors use Pentaherbs Formula to educate to readers on efforts in Traditional Chinese Medicine research to adopt this historic and unique complementary medicine as a safer and scientific-based therapy for atopic dermatitis.In closing, Atopic Dermatitis: From Diagnosis to Treatment focuses on topical corticosteroids that are commonly used by dermatologists and general physicians to treat selected difficult dermatoses effectively.
This book presents the state of the art in research into atopic dermatitis, or atopic eczema, and provides numerous effective practical management recommendations that are grounded in the immense clinical experience of the author. A scientific evidence-based approach to the subject is adopted, progressing from clinical symptoms in different disease stages, molecular genetics, and pathophysiology through to treatment and prevention. All aspects of patient management are covered, including diagnostics, avoidance strategies, emollient therapy, and acute treatment of eczema and itch. Diverse special therapeutic approaches are discussed, ranging from glucocorticoids, topical calcineurin inhibitors, and antimicrobial therapy through to UV therapy, allergen-specific immunotherapy, systemic immunosuppressive therapy, and emerging options. Environmental influences are considered, and there is a focus on the whole human being, with attention to psychosocial aspects of the disease and the benefit of educational programs such as “eczema schools”. Atopic Dermatitis will be invaluable for dermatologists, allergists, pediatricians, and general practitioners and informative for other interested persons and sufferers.
Contact urticaria syndrome was first defined in 1975 and since then scientific interest has steadily increased. New cases are continuously being reported furnishing information on novel clinical features. A large number of compounds could be responsible for triggering the syndrome including fragrances, cosmetics, latex, preservatives, flavorings, a
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
State-of-the-art review on atopic eczema, one of the most common skin diseases today. This multi-authored handbook covers all aspects relevant for physicians from various disciplines.
This accurate, profusely illustrated guide to the diagnosis and treatment of skin abnormalities and diseases covers various topical therapies as well as specific skin diseases such as dermatitis, warts, diseases, and tumors. It also details surgical procedures and chemical peels.
Management of Generalized Dermatitis in Clinical Practice translates the mechanisms of dermatitis from basic science evidence to practice based recommendations for clinical care. The role of allergic contact dermatitis in atopic dermatitis is explored in depth. Primary care physicians, allergists, and dermatologists will enjoy the fresh perspective that moves beyond treatment with corticosteroids and provides diagnostic and therapeutic algorithms for this complex condition.
Sensitive skin is a widely reported condition where there is subjective cutaneous hyper-reactivity to environmental factors. Progress has been made in many aspects of the background science that will help clinicians in their management of patients presenting with the condition. This new text sums up the advances in thinking on pathophysiology, classification, methods of investigation, and the different susceptibilities of different types of skin.
A wide-ranging account of the epidemiology of atopic eczema, its prevalence and possible causes.