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The brain is the most complex computational device we know, consisting of highly interacting and redundant networks of areas, supporting specific brain functions. The rules by which these areas organize themselves to perform specific computations have only now started to be uncovered. Advances in non-invasive neuroimaging technologies have revolutionized our understanding of the functional anatomy of cortical circuits in health and disease states, which is the focus of this book. The first section of this book focuses on methodological issues, such as combining functional MRI technology with other brain imaging modalities. The second section examines the application of brain neuroimaging to understand cognitive, visual, auditory, motor and decision-making networks, as well as neurological diseases. The use of non-invasive neuroimaging technologies will continue to stimulate an exponential growth in understanding basic brain processes, largely as a result of sustained advances in neuroimaging methods and applications.
This issue of Radiologic Clinics focuses on Advanced Neuroimaging in Brain Tumors and is edited by Dr. Sangam Kanekar. Articles will include: Imaging findings of new entities and patterns in brain tumor: IDH mutant, IDH wildtype, Codeletion, and MGMT methylation; CT and MR perfusion imaging in neuro-oncology; Application of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in the pre- and post-surgical evaluation of brain tumor; Clinical applications of magnetic resonance spectroscopy (MRS) in of brain tumors: grading and recurrence; Cellular and molecular imaging with PET and SPECT in brain tumors; Role of Functional MRI (fMRI) in the presurgical mapping of brain tumor; Imaging surveillance of gliomas: role of advanced imaging techniques; Neoplastic meningitis and paraneoplastic syndrome—role of imaging; Imaging of neurologic injury following oncologic therapy; RadioGenomics of brain tumor; Imaging mimics of brain tumors; Imaging of tumor syndromes; and more!
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease.
Over the last decade, some of the greatest achievements in the field of neuroimaging have been related to remarkable advances in magnetic resonance techniques, including diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. Such techniques have provided valuable insights into tissue microstructure, microvasculature, metabolism and brain connectivity. Previously available mostly in research environments, these techniques are now becoming part of everyday clinical practice in a plethora of clinical MR systems. Nevertheless, despite growing interest and wider acceptance, there remains a lack of a comprehensive body of knowledge on the subject, exploring the intrinsic complexity and physical difficulty of the techniques. This book focuses on the basic principles and theories of diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. It also explores their clinical applications and places emphasis on the associated artifacts and pitfalls with a comprehensive and didactic approach. This book aims to bridge the gap between research applications and clinical practice. It will serve as an educational manual for neuroimaging researchers and radiologists, neurologists, neurosurgeons, and physicists with an interest in advanced MR techniques. It will also be a useful reference text for experienced clinical scientists who wish to optimize their multi-parametric imaging approach.
Meditation techniques, including mindfulness, have become popular wellbeing practices and the scientific study of their effects has recently turned 50 years old. But how much do we know about them: what were they developed for and by whom? How similar or different are they, how effective can they be in changing our minds and biology, what are their social and ethical implications? The Oxford Handbook of Meditation is the most comprehensive volume published on meditation, written in accessible language by world-leading experts on the science and history of these techniques. It covers the development of meditation across the world and the varieties of its practices and experiences. It includes approaches from various disciplines, including psychology, neuroscience, history, anthropology, and sociology and it explores its potential for therapeutic and social change, as well as unusual or negative effects. Edited by practitioner-researchers, this book is the ultimate guide for all interested in meditation, including teachers, clinicians, therapists, researchers, or anyone who would like to learn more about this topic.
Medical Physics covers the applied branch of physics concerned with the application of concepts and methods of physics to diagnostics and therapeutics of human diseases. The first part, Physical and Physiological Aspects of the Body, covers those body systems that have a strong physical component, such as body mechanics, energy household, action potential, signal transmission in neurons, respiratory and circulatory system as well as visual and sound perception. The second part of this volume, Imaging Modalities without Ionizing Radiation, introduces sonography, endoscopy, and magnetic resonance imaging. The second volume complements the imaging modalities with the use of ionizing radiation: x-ray radiography, scintigraphy, SPECT, and PET. This first part is followed by chapters on radiation treatment of tumors, in particular x-ray radiotherapy, proton and neutron radiation therapy, and brachytherapy. The last part treats aspects of diagnostics and therapeutics beyond radiology, including laser applications, multifunctional nanoparticles and prosthetics. This first volume - connects the basic principles of physics with the functionality of the body and with physical methods used for diagnostics and therapeutics. - covers the first part of the entire field, including the physics of the body and imaging methods without the use of ionizing radiation. - provides an introduction for Bachelor students to the main concepts of Medical Physics during their first semesters guiding them to further specialized and advanced literature. - contains many questions & answers related to the content of each chapter. - is also available as a set together with Volume 2. Contents Part A: Physical and physiological aspects of the body Brief overview of body parts and functions Body mechanics and muscles Elastomechanics: bones and fractures Energy household of the body Resting potential and action potential Signal transmission in neurons Electrophysical aspects of the heart The circulatory system The respiratory system Kidneys Basic mechanism of vision Sound and sound perception Part B: Imaging modalities without ionizing radiation Sonography Endoscopy Magnetic resonance imaging Questions & answers
This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.