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By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.
The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Vorrangig werden radiologische und Ultraschallverfahren vorgestellt. Komplexere Bildgebungsverfahren wie Computertomographie und MRT werden ebenfalls präsentiert. Das Referenzwerk enthält mehr als 1.750 hochwertige Abbildungen und ist eine wahre Fundgrube für Veterinärmediziner, die sich insbesondere auf die Behandlung von Katzen spezialisiert haben. Feline Diagnostic Imaging beschäftigt sich zunächst mit der Auswertung von unauffälligen und pathologischen Röntgenaufnahmen des Thorax, Abdomens und des Bewegungsapparats. Im Anschluss werden Diagnosen aus gängigen echokardiographischen und Ultraschalluntersuchungen erläutert. Auch beschreibt das Referenzwerk bildgebende Untersuchungen des Schädels mittels Computertomographie sowie Gehirn- und Wirbelsäulenerkrankungen, die über ein MRT erkannt werden können. - Präsentiert bildgebende Techniken und konzentriert sich dabei auf die Anforderungen bei der Untersuchung von Katzen. - Legt den Schwerpunkt auf gängige Verfahren, behandelt aber auch komplexere Bildgebungstechniken. - Gibt einen vollständigen Überblick über diagnostischen Imaging-Verfahren bei Katzen. - Mit einer Fülle von Tipps und Tricks für die Behandlung von Katzen. - Ein Muss für Veterinärmediziner, die sich auf Katzen spezialisiert haben. Feline Diagnostic Imaging legt in einzigartiger Weise der Fokus auf Katzen und ist daher ein Muss für Veterinärmediziner, die ihre Kompetenzen bei diagnostischen Bildgebungsverfahren verbessern möchten. Das Buch eignet sich ebenfalls hervorragend für Fachtierärzte für Radiologie, Studenten der Veterinärmedizin und Kliniker.
Several genetic, biochemical and radiologic discoveries have impacted the management of endocrine hypertension, while surgical procedures have revolutionized treatment of patients with endocrine hypertension. This text contains the proceedings of a 2001 workshop on the topic.
Atlas of Endocrine Pathology provides a comprehensive compendium of photomicrographs of common and uncommon entities in endocrine pathology. The volume includes histologic features of normal features, reactive conditions, hyperplasia and tumors. The most helpful diagnostic features are illustrated to provide direction and clues to the diagnosis of endocrine tumors. Furthermore, photomicrographs highlight the most pertinent diagnostic features in problematic diagnoses in endocrine pathology. Authored by a nationally and internationally recognized pathologist, Atlas of Endocrine Pathology is an important learning tool for those becoming familiar with the diverse entities encountered in endocrine pathology and a valuable reference for practicing pathologists faced with challenging diagnoses in endocrine pathology.
This practical resource provides the latest evidence, management strategies and recommendations for the treatment of disorders of the adrenal glands, including related physiology, genetics and pharmacology. This book is divided into three thematic sections. The first covers adrenal physiology, presenting adrenal zonation and development, the regulation of steroidogenesis, and the pharmacology of glucocortisoids. Part two discusses the genetics and pathophysiology of a number of adrenal disorders, including autoimmune Addison’s disease, congenital adrenal hyperplasia, primary aldosteronism, adrenocortical tumors and hyperplasias, and pheochromocytomas and paragangliomas. The final section presents the latest diagnostic and management strategies for these disorders, addressing adrenal insufficiency, adrenal Cushing’s Syndrome and aldosteronism, among others. Over the past twenty years, our understanding of disorders of the adrenal glands has been altered and deepened. Providing a much-needed update to the literature, Adrenal Disorders: Physiology, Pathophysiology and Treatment will be an important resource for both academic and clinical endocrinologists working with the adrenal glands and managing patients with adrenal disorders.
The present book provides a state-of-the-art overview of the adrenal gland pathophysiology. It covers both up-to-date basic and clinical notions on adrenal glands. Amidst the molecular aspects, discussed by leading scientists in the field, there are ER stress, microRNA, hormone biosynthesis, and interactions with other organs. Clinical insights for students and physicians are also provided, from the imaging to the therapeutic management of common disorders of the gland, including adrenal failure, hyperaldosteronism, Cushing's syndrome, neurologic disease, and cancer both in adults and pediatric patients. As mentioned above, chapter contributions are made by worldwide renowned experts, scientists and physicians, working in prestigious hospitals and universities including Brown, Oxford, Case Western Reserve University, Cleveland Clinic, Chinese University of Honk Kong, University of Tennessee, Indiana University School of Medicine, Monash Health in Clayton, Australia, University of Calgary, Northern Ontario School of Medicine and Laurentian University, Medical University of Gdańsk, Université Pierre et Marie Curie in Paris, France, University of Minho, Braga, Portugal, St. Vincent's University Hospital in Dublin, Universities of Londrina, Alfenas, Sao Paulo, and Rio de Janeiro, Brazil. Throughout these chapters, the authors spotlight future avenues for research in basic pathophysiology and in therapy/prevention, in addition to thorough overviews of the current literature pertaining to the adrenal gland and its functional roles. The book also includes several color photographs, schemes and diagrams of molecular relationships, and tables that support and complement the text. The comprehensive and systematic overview provided within this book is expected to assist the reader in comprehending the importance of taking into account the functional roles of the adrenal gland and also to address questions and unresolved issues regarding the treatment of its disorders. Finally, the editor would like to express his sincere appreciation to all the contributors for their dedicated collaboration in this project. He would also like to thank Ms. Carra Feagaiga for her patient support. He sincerely hopes this book will enable readers to connect basic research principles with up-to-date clinical knowledge, thereby encouraging future discoveries and developments of new therapeutic strategies to treat disorders of the adrenal gland.
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.