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​​The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer. The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation.
THE EVOLUTIONARY STRATEGIES THAT SHAPE ECOSYSTEMS In 1837 a young Charles Darwin took his notebook, wrote “I think”, and then sketched a rudimentary, stick-like tree. Each branch of Darwin’s tree of life told a story of survival and adaptation – adaptation of animals and plants not just to the environment but also to life with other living things. However, more than 150 years since Darwin published his singular idea of natural selection, the science of ecology has yet to account for how contrasting evolutionary outcomes affect the ability of organisms to coexist in communities and to regulate ecosystem functioning. In this book Philip Grime and Simon Pierce explain how evidence from across the world is revealing that, beneath the wealth of apparently limitless and bewildering variation in detailed structure and functioning, the essential biology of all organisms is subject to the same set of basic interacting constraints on life-history and physiology. The inescapable resulting predicament during the evolution of every species is that, according to habitat, each must adopt a predictable compromise with regard to how they use the resources at their disposal in order to survive. The compromise involves the investment of resources in either the effort to acquire more resources, the tolerance of factors that reduce metabolic performance, or reproduction. This three-way trade-off is the irreducible core of the universal adaptive strategy theory which Grime and Pierce use to investigate how two environmental filters selecting, respectively, for convergence and divergence in organism function determine the identity of organisms in communities, and ultimately how different evolutionary strategies affect the functioning of ecosystems. This book refl ects an historic phase in which evolutionary processes are finally moving centre stage in the effort to unify ecological theory, and animal, plant and microbial ecology have begun to find a common theoretical framework. Companion website This book has a companion website www.wiley.com/go/grime/evolutionarystrategies with Figures and Tables from the book for downloading.
Life History Evolution represents a synthetic approach to the understanding of the evolution of life history variation using the three types of environment (constant, stochastic, predictable) as the focus under which the theory is developed and tested. First, the author outlines a general framework for the study and analysis of life history variation, bringing together the approaches of quantitative genetic modeling and optimality analysis. Using this framework, he then discusses how life histories evolve in the three different types of environments, each of which presents unique characteristics. The theme of the book is that an understanding of evolutionary change requires analysis at both the genetic and phenotypic levels, and that the environment plays a central role in such analyses. Intended for graduate students and researchers, the book's emphasis is on assumptions and testing of models. Mathematical processes are described, but mathematical derivations are kept to a minimum. Each chapter includes a summary, and boxes provide supplementary material.
Evolution since Darwin: The First 150 Years comprises 22 chapters and eight shorter commentaries that emerged from a symposium held in November 2009 at Stony Brook University, USA. Thirty-nine authors from 22 universities and two museums in five countries write on areas of evolutionary biology and related topics on which their research focuses. Their essays cover the history of evolutionary biology, populations, genes and genomes, evolution of form, adaptation and speciation, diversification and phylogeny, paleobiology, human cultural and biological evolution, and applied evolution. The volume summarizes progress in major areas of research in evolutionary biology since Darwin, reviewing the current state of knowledge and active research in those areas, and looking toward the future of the broader field.
Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€"recombinant DNA, scanning tunneling microscopes, and moreâ€"are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€"for funding, effective information systems, and other supportâ€"of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.
With more than 500 species distributed all around the Northern Hemisphere, the genus Quercus L. is a dominant element of a wide variety of habitats including temperate, tropical, subtropical and mediterranean forests and woodlands. As the fossil record reflects, oaks were usual from the Oligocene onwards, showing the high ability of the genus to colonize new and different habitats. Such diversity and ecological amplitude makes genus Quercus an excellent framework for comparative ecophysiological studies, allowing the analysis of many mechanisms that are found in different oaks at different level (leaf or stem). The combination of several morphological and physiological attributes defines the existence of different functional types within the genus, which are characteristic of specific phytoclimates. From a landscape perspective, oak forests and woodlands are threatened by many factors that can compromise their future: a limited regeneration, massive decline processes, mostly triggered by adverse climatic events or the competence with other broad-leaved trees and conifer species. The knowledge of all these facts can allow for a better management of the oak forests in the future.
Generations of plant scientists have been fascinated by alpine plant lifean ecosystem that experiences dramatic climatic gradients over a very short distance. This comprehensive book examines a wide range of topics including alpine climate and soils, plant distribution and the treeline phenomenon, plant stress and development, global change at high elevation, and the human impact on alpine vegetation. Geographically, the book covers all parts of the world including the tropics.
Southwestern Australia is unique as it contains the world’s most nutrient-impoverished soils, experiences a prolonged-summer period and the vegetation is extremely fire-prone. It is also world-renowned for its relative high level of flora biodiversity. This book focuses on the diverse range of morphological and physiological adaptations evolved by the flora to survive in the harsh Mediterranean-type climate.
By joining phylogenetics and evolutionary ecology, this book explores the patterns of parasite diversity while revealing diversification processes.