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As fifteen-year-old Kit does chores on her family's Vermont farm, she puzzles over her mother's apparent unhappiness, complains about being homeschooled after a minor incident at school, and strives to communicate just how important dance is to her.
Sixteen-year-old Kit Tyler is marked by suspicion and disapproval from the moment she arrives on the unfamiliar shores of colonial Connecticut in 1687. Alone and desperate, she has been forced to leave her beloved home on the island of Barbados and join a family she has never met. Torn between her quest for belonging and her desire to be true to herself, Kit struggles to survive in a hostile place. Just when it seems she must give up, she finds a kindred spirit. But Kit's friendship with Hannah Tupper, believed by the colonists to be a witch, proves more taboo than she could have imagined and ultimately forces Kit to choose between her heart and her duty. Elizabeth George Speare won the 1959 Newbery Medal for this portrayal of a heroine whom readers will admire for her unwavering sense of truth as well as her infinite capacity to love.
A “must-read” (The Washington Post) funny and practical guide to help you find, build, and keep the relationship of your dreams. Have you ever looked around and wondered, “Why has everyone found love except me?” You’re not the only one. Great relationships don’t just appear in our lives—they’re the culmination of a series of decisions, including whom to date, how to end it with the wrong person, and when to commit to the right one. But our brains often get in the way. We make poor decisions, which thwart us on our quest to find lasting love. Drawing from years of research, behavioral scientist turned dating coach Logan Ury reveals the hidden forces that cause those mistakes. But awareness on its own doesn’t lead to results. You have to actually change your behavior. Ury shows you how. This “simple-to-use guide” (Lori Gottlieb, New York Times bestselling author of Maybe You Should Talk to Someone) focuses on a different decision in each chapter, incorporating insights from behavioral science, original research, and real-life stories. You’ll learn: -What’s holding you back in dating (and how to break the pattern) -What really matters in a long-term partner (and what really doesn’t) -How to overcome the perils of online dating (and make the apps work for you) -How to meet more people in real life (while doing activities you love) -How to make dates fun again (so they stop feeling like job interviews) -Why “the spark” is a myth (but you’ll find love anyway) This “data-driven” (Time), step-by-step guide to relationships, complete with hands-on exercises, is designed to transform your life. How to Not Die Alone will help you find, build, and keep the relationship of your dreams.
Going flying – even in winter when it's stormy and snowing outside - is a long-cherished dream of model pilots. Until just a few years ago, the fulfilment of this dream of flying indoors was reserved for only a few specialists. Only the discovery of the material "Depron" for model flying, brushless motors and LiPo batteries as well as the ever smaller and lighter components for the RC system make possible flying weights and performances with which even demanding aerobatics, including 3D flight, can be realised. This book makes it easier for the interested model pilot to get started in indoor (aerobatic) flying and gives tips on equipment as well as on building an indoor flying model. From the content: • Silhouette or full fuselage, self-built or finished model? • CFRP profiles, Depron, surface design • Motor, controller, batteries, connectors, charging station • The RC components - transmitter, receiver, servos, rudder linkages, pushrods, cable linkages, • Tips on material processing and assembly • Tips for flying in - flying technique in the hangar and first aerobatic manoeuvres • Illustrated repair instructions for a damaged front wing • Requirements for the hall, contact persons, safety rules, hall regulations, • "preparation" of the hall and special features of the unfamiliar environment • Tabular compilation of the models used
Issues in Prevention, Diagnostics, Screening, Statistics, and Testing: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Translational Medicine. The editors have built Issues in Prevention, Diagnostics, Screening, Statistics, and Testing: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Translational Medicine in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Prevention, Diagnostics, Screening, Statistics, and Testing: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.
Molecular hydrogen (H2) is an important molecule in the metabolism of diverse microorganisms. It is used either as energy source or for the disposal of reducing equivalents depending on environmental conditions. Furthermore, H2 transmits energy between different species within microbial communities. The enzymes that split or evolve H2 are called hydrogenases and these metalloproteins can be divided into three phylogenetically unrelated classes distinguishable by the metal composition of their active sites, namely [Fe]-, [FeFe]-, and [NiFe]- hydrogenases. Following a century of hydrogenase research, it is now possible to isolate, handle, and investigate these fragile enzymes. There have been numerous advances in understanding the regulation, function, structures, and maturation of these enzymes, as well as their involvement in important processes such as microbial pathogenesis and biogeochemical cycling. The employment of hydrogenases and hydrogenase-based applications could also potentially facilitate the world’s transition to a future sustainable H2-based energy economy.
Cirrhosis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Cirrhosis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cirrhosis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.