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Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.
The New World’s earliest Jewish immigrants and their unique, little-known history: A New York Times bestseller from the author of Life at the Dakota. In 1654, twenty-three Jewish families arrived in New Amsterdam (now New York) aboard a French privateer. They were the Sephardim, members of a proud orthodox sect that had served as royal advisors and honored professionals under Moorish rule in Spain and Portugal but were then exiled from their homeland by intolerant monarchs. A small, closed, and intensely private community, the Sephardim soon established themselves as businessmen and financiers, earning great wealth. They became powerful forces in society, with some, like banker Haym Salomon, even providing financial support to George Washington’s army during the American Revolution. Yet despite its major role in the birth and growth of America, this extraordinary group has remained virtually impenetrable and unknowable to outsiders. From author of “Our Crowd” Stephen Birmingham, The Grandees delves into the lives of the Sephardim and their historic accomplishments, illuminating the insulated world of these early Americans. Birmingham reveals how these families, with descendants including poet Emma Lazarus, Barnard College founder Annie Nathan Meyer, and Supreme Court Justice Benjamin N. Cardozo, influenced—and continue to influence—American society.
The final volume in this tripartite series on Brain Augmentation is entitled “From Clinical Applications to Ethical Issues and Futuristic Ideas”. Many of the articles within this volume deal with translational efforts taking the results of experiments on laboratory animals and applying them to humans. In many cases, these interventions are intended to help people with disabilities in such a way so as to either restore or extend brain function. Traditionally, therapies in brain augmentation have included electrical and pharmacological techniques. In contrast, some of the techniques discussed in this volume add specificity by targeting select neural populations. This approach opens the door to where and how to promote the best interventions. Along the way, results have empowered the medical profession by expanding their understanding of brain function. Articles in this volume relate novel clinical solutions for a host of neurological and psychiatric conditions such as stroke, Parkinson’s disease, Huntington’s disease, epilepsy, dementia, Alzheimer’s disease, autism spectrum disorders (ASD), traumatic brain injury, and disorders of consciousness. In disease, symptoms and signs denote a departure from normal function. Brain augmentation has now been used to target both the core symptoms that provide specificity in the diagnosis of a disease, as well as other constitutional symptoms that may greatly handicap the individual. The volume provides a report on the use of repetitive transcranial magnetic stimulation (rTMS) in ASD with reported improvements of core deficits (i.e., executive functions). TMS in this regard departs from the present-day trend towards symptomatic treatment that leaves unaltered the root cause of the condition. In diseases, such as schizophrenia, brain augmentation approaches hold promise to avoid lengthy pharmacological interventions that are usually riddled with side effects or those with limiting returns as in the case of Parkinson’s disease. Brain stimulation can also be used to treat auditory verbal hallucination, visuospatial (hemispatial) neglect, and pain in patients suffering from multiple sclerosis. The brain acts as a telecommunication transceiver wherein different bandwidth of frequencies (brainwave oscillations) transmit information. Their baseline levels correlate with certain behavioral states. The proper integration of brain oscillations provides for the phenomenon of binding and central coherence. Brain augmentation may foster the normalization of brain oscillations in nervous system disorders. These techniques hold the promise of being applied remotely (under the supervision of medical personnel), thus overcoming the obstacle of travel in order to obtain healthcare. At present, traditional thinking would argue the possibility of synergism among different modalities of brain augmentation as a way of increasing their overall effectiveness and improving therapeutic selectivity. Thinking outside of the box would also provide for the implementation of brain-to-brain interfaces where techniques, proper to artificial intelligence, could allow us to surpass the limits of natural selection or enable communications between several individual brains sharing memories, or even a global brain capable of self-organization. Not all brains are created equal. Brain stimulation studies suggest large individual variability in response that may affect overall recovery/treatment, or modify desired effects of a given intervention. The subject’s age, gender, hormonal levels may affect an individual’s cortical excitability. In addition, this volume discusses the role of social interactions in the operations of augmenting technologies. Finally, augmenting methods could be applied to modulate consciousness, even though its neural mechanisms are poorly understood. Finally, this volume should be taken as a debate on social, moral and ethical issues on neurotechnologies. Brain enhancement may transform the individual into someone or something else. These techniques bypass the usual routes of accommodation to environmental exigencies that exalted our personal fortitude: learning, exercising, and diet. This will allow humans to preselect desired characteristics and realize consequent rewards without having to overcome adversity through more laborious means. The concern is that humans may be playing God, and the possibility of an expanding gap in social equity where brain enhancements may be selectively available to the wealthier individuals. These issues are discussed by a number of articles in this volume. Also discussed are the relationship between the diminishment and enhancement following the application of brain-augmenting technologies, the problem of “mind control” with BMI technologies, free will the duty to use cognitive enhancers in high-responsibility professions, determining the population of people in need of brain enhancement, informed public policy, cognitive biases, and the hype caused by the development of brain- augmenting approaches.
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The world's most comprehensive, well documented, and well illustrated book on this subject. With extensive subject and geographical index. 30 photographs and illustrations - mostly color. Free of charge in digital PDF format.
This collection of essays represents research currently being undertaken on women's lives and their representations in various ancient societies. It provides a forum for the exchange and development of ideas and methods at a crucial period in the growth of women's studies in the UK.
“Christopher Sykes has written the authoritative work on the Palestine Mandate... His account is almost unbearably fair to all concerned, even to Britain... a very excellent book. Mr. Sykes steers his way through the reigns of successive High Commissioners and through the maze of White Papers and Royal Commissions with amazing virtuosity. We see the whole picture of the Mandate in a way which was impossible to those at the time.” — International Affairs “Mr. Sykes (son of Mark Sykes, co-author of the Sykes-Picot Agreement) has written an illuminating, highly-informed and balanced study of the development of the Zionist movement into the State of Israel. By virtue of his acquaintance with many of the leading persons involved, Mr. Sykes has had access to a considerable amount of unpublished material upon which he has drawn heavily to clarify much that was previously obscure about events in the unhappy Holy Land. He also writes with an easy, lucid style so that apart from the book’s intrinsic merit it is immensely readable.” — International Journal “One of the many merits of Mr Sykes’s wholly meritorious book is that he is not anchored in time or prejudice.” — Middle Eastern Studies
First published in 1957, Nathan Glazer's classic, historical study of Judaism in America has been described by the New York Times Book Review as "a remarkable story . . . told briefly and clearly by an objective historical mind, yet with a fine combination of sociological insight and religious sensitivity." Glazer's new introduction describes the drift away from the popular equation of American Judaism with liberalism during the last two decades and considers the threat of divisiveness within American Judaism. Glazer also discusses tensions between American Judaism and Israel as a result of a revivified Orthodoxy and the disillusionment with liberalism. "American Judaism has been arguably the best known and most used introduction to the study of the Jewish religion in the United States. . . . It is an inordinately clear-sighted work that can be read with much profit to this day."—American Jewish History (1987)
This book studies the role of the Ottoman Empire and Republic of Turkey in providing refuge and prosperity for Jews fleeing from persecution in Europe and Byzantium in medieval times and from Russian pogroms and the Nazi holocaust in the nineteenth and twentieth centuries. It studies the religiously-based communities of Ottoman and Turkish Jews as well as their economic, cultural and religious lives and their relations with the Muslims and Christians among whom they lived.