Loyd Thompson
Published: 2017-10-30
Total Pages: 980
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Excerpt from The American Journal of Syphilis, Vol. 1: January, April, July, October, 1917 Kolle and Rothermundt11 regarded chicken spirillosis as a favor able experimental infection to work with. Known mercurials which possess value in the treatment of syphilis, exhibit a favorable in fluence in chicken spirillosis. This fact makes the infection with the spirocheta gallinarum a good test for the determination of the value of new mercurial compounds. Experiments with Asurol, dinitro mercuri-diphenyl-carboxylic acid and other new synthetic mercury compounds, demonstrated that they were not superior to any of the known preparations. The working hypothesis advanced by Blumen thal, that therapeutically active mercurial compounds must possess an affinity for liver cells, and the opinion of Schrauth and Schoeller concerning the necessity of mercury being firmly attached to the or ganie molecule in half complex form, were not concurred in by the authors; they invoked data based upon actual experimentation in support of their adverse views. They held that the therapeutic value of a mercurial preparation bore no relationship to the firm ness of mercury in the molecule nor to the fact that the compound was a precipitant for protein, nor to the solubility or insolubility of the compound. The establishing of the therapeutic index was re garded by them as most important; i. E., the relationship of the dosis lethalis to the dosis therapeutica, as proposed by Ehrlich. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.