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Beginning with the germ theory of disease in the 19th century and extending through most of the 20th century, microbes were believed to live their lives as solitary, unicellular, disease-causing organisms . This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. Most such inquiries were designed to identify microbial pathogens by satisfying Koch's postulates.3 This pathogen-centric approach to the study of microorganisms produced a metaphorical "war" against these microbial invaders waged with antibiotic therapies, while simultaneously obscuring the dynamic relationships that exist among and between host organisms and their associated microorganisms-only a tiny fraction of which act as pathogens. Despite their obvious importance, very little is actually known about the processes and factors that influence the assembly, function, and stability of microbial communities. Gaining this knowledge will require a seismic shift away from the study of individual microbes in isolation to inquiries into the nature of diverse and often complex microbial communities, the forces that shape them, and their relationships with other communities and organisms, including their multicellular hosts. On March 6 and 7, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats hosted a public workshop to explore the emerging science of the "social biology" of microbial communities. Workshop presentations and discussions embraced a wide spectrum of topics, experimental systems, and theoretical perspectives representative of the current, multifaceted exploration of the microbial frontier. Participants discussed ecological, evolutionary, and genetic factors contributing to the assembly, function, and stability of microbial communities; how microbial communities adapt and respond to environmental stimuli; theoretical and experimental approaches to advance this nascent field; and potential applications of knowledge gained from the study of microbial communities for the improvement of human, animal, plant, and ecosystem health and toward a deeper understanding of microbial diversity and evolution. The Social Biology of Microbial Communities: Workshop Summary further explains the happenings of the workshop.
This book explores the significance of soil microbial diversity to understand its utility in soil functions, ecosystem services, environmental sustainability, and achieving the sustainable development goals. With a focus on agriculture and environment, the book highlights the importance of the microbial world by providing state-of-the-art technologies for examining the structural and functional attributes of soil microbial diversity for applications in healthcare, industrial biotechnology, and bioremediation studies. In seven chapters, the book will act as a primer for students, environmental biotechnologists, microbial ecologists, plant scientists, and agricultural microbiologists. Chapter 1 introduces readers to the soil microbiome, and chapter 2 discusses the below ground microbial world. Chapter 3 addresses various methods for exploring microbial diversity, chapter 4 discusses the genomics methods, chapter 5 provides the metaproteomics and metatranscriptomics approaches and chapter 6 details the bioinformatics tools for soil microbial community analysis, and chapter 7 concludes the text with future perspectives on further soil microbial uses and applications.
An agricultural revolution is sweeping the land. Appreciation for high-quality food, often locally grown, an awareness of the fragility of our farmlands, and a new generation of young people interested in farming, animals, and respect for the earth have come together to create a new agrarian community. To this group of farmers, chefs, activists, and visionaries, Letters to a Young Farmer is addressed. Three dozen esteemed leaders of the changes that made this revolution possible speak to the highs and lows of farming life in vivid and personal letters specially written for this collaboration. Barbara Kingsolver speaks to the tribe of farmers—some born to it, many self-selected—with love, admiration, and regret. Dan Barber traces the rediscovery of lost grains and foodways. Michael Pollan bridges the chasm between agriculture and nature. Bill McKibben connects the early human quest for beer to the modern challenge of farming in a rapidly changing climate. Letters to a Young Farmer is a vital road map of how we eat and farm, and why now, more than ever before, we need farmers.
The book Methods in Silkworm Microbiology is the first ever publication that provides in-depth reviews on the latest progresses about silkworm -pathogen interactions, diseases and management practices for sustainable development of sericulture. Different molecular and immunodiagnostic methods for the detection of pathogens have been comprehensively addressed. Most recent advancements on the role of Micro RNAs in silkworm and pathogen interactions are provided with suitable illustrations. Recent technological advances and emerging trends in exploring silkworm gut microbial communities towards translation research, particularly to understand microbiome functions have been highlighted. Information on various immune mechanisms of silkworm against invading pathogens is summarized. The book further highlights the silkworm gut microbiota as a potential source for biotechnological applications. Provide comprehensive reviews and valuable methods from the selected experts on the topic "Methods in silkworm microbiology/pathology" Provides latest information on application of genomics and transcriptomics to decipher silkworm gut microbial communities. Different molecular and immunodiagnostic methods for the detection of pathogens have been comprehensively addressed Provides up to date information on silkworm-pathogen interactions, different silkworm diseases and immune mechanisms
“A fascinating, funny, and easy-to-read book about the latest human microbiome discoveries and how these discoveries might help us tend to our inner microbes so as to optimize our overall health.” —Daphne Miller, MD author of Farmacology: Total health from the Ground Up and The Jungle Effect “Virtually every aspect of health and vitality is influenced by the collection of microbes living within us. The Good Gut empowers the reader with the opportunity to embrace this leading edge science in an actionable, user-friendly way.” —David Perlmutter, MD and author, #1 New York Times Bestseller, Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar: Your Brain's Silent Killers The groundbreaking science behind the surprising source of good health Stanford University’s Justin and Erica Sonnenburg are pioneers in the most exciting and potentially transformative field in the entire realm of human health and wellness, the study of the relationship between our bodies and the trillions of organisms representing thousands of species to which our bodies play host, the microbes that we collectively call the microbiota. The microbiota interacts with our bodies in a number of powerful ways; the Sonnenburgs argue that it determines in no small part whether we’re sick or healthy, fit or obese, sunny or moody. The microbiota has always been with us, and in fact has coevolved with humans, entwining its functions with ours so deeply, the Sonnenburgs show us, humans are really composite organisms having both microbial and human parts. But now, they argue, because of changes to diet, antibiotic over-use, and over-sterilization, our gut microbiota is facing a “mass extinction event,” which is causing our bodies to go haywire, and may be behind the mysterious spike in some of our most troubling modern afflictions, from food allergies to autism, cancer to depression. It doesn’t have to be this way. The Good Gut offers a new plan for health that focuses on how to nourish your microbiota, including recipes and a menu plan. In this groundbreaking work, the Sonnenburgs show how we can keep our microbiota off the endangered species list and how we can strengthen the community that inhabits our gut and thereby improve our own health. The answer is unique for each of us, and it changes as you age. In this important and timely investigation, the Sonnenburgs look at safe alternatives to antibiotics; dietary and lifestyle choices to encourage microbial health; the management of the aging microbiota; and the nourishment of your own individual microbiome. Caring for our gut microbes may be the most important health choice we can make.
This book encompasses the current knowledge of plant microbiomes and their potential biotechnological application for plant growth, crop yield and soil health for sustainable agriculture. The plant microbiomes (rhizospheric, endophytic and epiphytic) play an important role in plant growth, development, and soil health. Plant and rhizospheric soil are a valuable natural resource harbouring hotspots of microbes, and it plays critical roles in the maintenance of global nutrient balance and ecosystem function. The diverse group of microbes is key components of soil–plant systems, where they are engaged in an intense network of interactions in the rhizosphere/endophytic/phyllospheric. The rhizospheric microbial diversity present in rhizospheric zones has a sufficient amount of nutrients release by plant root systems in form of root exudates for growth, development and activities of microbes. The endophytic microbes are referred to those microorganisms, which colonize in the interior of the plant parts, viz root, stem or seeds without causing any harmful effect on host plant. Endophytic microbes enter in host plants mainly through wounds, naturally occurring as a result of plant growth, or through root hairs and at epidermal conjunctions. Endophytes may be transmitted either vertically (directly from parent to offspring) or horizontally (among individuals). The phyllosphere is a common niche for synergism between microbes and plant. The leaf surface has been termed as phyllosphere and zone of leaves inhabited by microorganisms as phyllosphere. The plant part, especially leaves, is exposed to dust and air currents resulting in the establishments of typical flora on their surface aided by the cuticles, waxes and appendages, which help in the anchorage of microorganisms. The phyllospheric microbes may survive or proliferate on leaves depending on extent of influences of material in leaf diffuseness or exudates. The leaf diffuseness contains the principal nutrients factors (amino acids, glucose, fructose and sucrose), and such specialized habitats may provide niche for nitrogen fixation and secretions of substances capable of promoting the growth of plants. The microbes associated with plant as rhizospheric, endophytic and epiphytic with plant growth promoting (PGP) attributes have emerged as an important and promising tool for sustainable agriculture. PGP microbes promote plant growth directly or indirectly, either by releasing plant growth regulators; solubilization of phosphorus, potassium and zinc; biological nitrogen fixation or by producing siderophore, ammonia, HCN and other secondary metabolites which are antagonistic against pathogenic microbes. The PGP microbes belong to different phylum of archaea (Euryarchaeota); bacteria (Acidobacteria, Actinobacteria, Bacteroidetes, Deinococcus-Thermus, Firmicutes and Proteobacteria) and fungi (Ascomycota and Basidiomycota), which include different genera namely Achromobacter, Arthrobacter, Aspergillus, Azospirillum, Azotobacter, Bacillus, Beijerinckia, Burkholderia, Enterobacter, Erwinia, Flavobacterium, Gluconoacetobacter, Haloarcula, Herbaspirillum, Methylobacterium, Paenibacillus, Pantoea, Penicillium, Piriformospora, Planomonospora, Pseudomonas, Rhizobium, Serratia and Streptomyces. These PGP microbes could be used as biofertilizers/bioinoculants at place of chemical fertilizers for sustainable agriculture. The aim of “Plant Microbiomes for Sustainable Agriculture” is to provide the current developments in the understanding of microbial diversity associated with plant systems in the form of rhizospheric, endophytic and epiphytic. The book is useful to scientist, research and students related to microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.
This book provides an overview of the latest advances concerning symbiotic relationships between plants and microbes, and their applications in plant productivity and agricultural sustainability. Symbiosis is a living phenomenon including dynamic variations in the genome, metabolism and signaling network, and adopting a multidirectional perspective on their interactions is required when studying symbiotic organisms. Although various plant-microbe symbiotic systems are covered in this book, it especially focuses on arbuscular mycorrhiza (AM) symbiosis and root nodule symbiosis, the two most prevalent systems. AM symbiosis involves the most extensive interaction between plants and microbes, in the context of phylogeny and ecology. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition, as well as the diversity of natural ecosystems, are frequently dependent upon the presence and activity of mycorrhizas. In turn, root nodule symbiosis includes morphogenesis and is formed by communication between plants and nitrogen-fixing bacteria. The biotechnological application of plant–microbe symbiosis is expected to foster the production of agricultural and horticultural products while maintaining ecologically and economically sustainable production systems. Designed as a hands-on guide, this book offers an essential resource for researchers and students in the areas of agri-biotechnology, soil biology and fungal biology.
The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts across different disciplines, this book focuses on the biochemical and anlayticial aspects of novel lipid signals, their pharmacological activities and their potential utilization for the development of new and effective therapeutic strategies. The first book of its kind, The Endocannabinoidome is a meaningful reference for all those involved in experimental efforts to further the development of this field. - Explores the novel and exciting aspects of several endocannabinoid-like molecules for which researchers are still seeking a function - Discusses the novel metabolic pathways for endocannabinoids in order to explain the failure of some clinical trials with inhibitors of more conventional metabolic pathways - Incorporates pharmacology, biochemistry and potential clinical applications to provide researchers with a complete look at endocannabinoids
Biosurfactants are structurally diverse group of bioactive molecules produced by a variety of microorganisms. They are secondary metabolites that accumulate at interfaces, reduce surface tension and form micellar aggregates. This research topic describes few novel microbial strains with a focus on increasing our understanding of genetics, physiology, regulation of biosurfactant production and their commercial potentials. A major stumbling block in the commercialization of biosurfactants is their high cost of production. Many factors play a significant role in making the process cost-effective and the most important one being the use of low-cost substrates such as agricultural residues for the production of biosurfactants. With the stringent government regulations coming into effect in favor of production and usage of the bio-based surfactants, many new companies aim to commercialize technologies used for the production of biosurfactants and to bring down costs. This Research Topic covers a compilation of original research articles, reviews and research commentary submitted by researchers enthusiastically working in the field of biosurfactants and highlights recent advances in our knowledge of the biosurfactants and understanding of the biochemical and molecular mechanisms involved in their production, scale-up and industrial applications. Apart from their diverse applications in the field of bioremediation, enhanced oil recovery, cosmetic, food and medical industries, biosurfactants can also boast off their unique eco-friendly nature to attract consumers and give the chemical surfactants a tough competition in the global market. This biosurfactant focused research topic aims to summarize the current achievements and explore the direction of development for the future generation of biosurfactants and bioemulsifiers. Some of the biosurfactant optimization processes presented are well-structured and already have a well-established research community. We wish to stimulate on-going discussions at the level of the biosurfactant production including common challenges in the process development, novel organisms and new feedstock and technologies for maximum benefit, key features of next generation biosurfactants and bioemulsifiers. We have compiled the research outputs of international leaders in the filed of biosurfactant particularly on the development of a state-of-the-art and highly-efficient process platform.
This book addresses “phyto-microbiome mediated stress regulation”. Fundamentally speaking, the microbial community’s importance for the survival of plants under stress conditions has already been confirmed. This book focuses on the roles of those rhizospheric microbiomes that are advantageous to plant developmental pathways. Gathering contributions by authors with specialized expertise in plant growth and health under stress conditions, as well as opportunistic pathogenic bacteria, the book reviews the functional aspects of rhizospheric microorganisms and how they impact plant health and disease. It offers a compendium of plant and microbial interactions at the level of multitrophic interactions, and identifies gaps between future demand and present research on plant stress. In closing, the authors highlight several directions for reshaping rhizosphere microbiomes in favor of microorganisms that are beneficial to plant growth and health.