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The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
DESCRIPTION Weatherization Technician Level One provides an overview of the materials and techniques used in constructing buildings along with the selection and installation of products used to reduce thermal loss. It also provides basic knowledge of HVAC ducts and duct systems as well as pipes and piping systems. The building science knowledge and specialized techniques learned from this program will give you the skills necessary to perform weatherization installations. INSTRUCTOR SUPPLEMENTS Instructors: Product supplements may be ordered directly through OASIS at http://oasis.pearson.com. For more information contact your Pearson NCCER/Contren Sales Specialist at http://nccer.pearsonconstructionbooks.com/store/sales.aspx. Weatherization Technician Level 1 AIG 9780132569842 PowerPoint CD 9780132569811 Stand-alone Test Gen Access Code Card 9780132494984