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This book discusses all the major topics of complex analysis, beginning with the properties of complex numbers and ending with the proofs of the fundamental principles of conformal mappings. Topics covered in the book include the study of holomorphic and analytic functions, classification of singular points and the Laurent series expansion, theory of residues and their application to evaluation of integrals, systematic study of elementary functions, analysis of conformal mappings and their applications—making this book self-sufficient and the reader independent of any other texts on complex variables. The book is aimed at the advanced undergraduate students of mathematics and engineering, as well as those interested in studying complex analysis with a good working knowledge of advanced calculus. The mathematical level of the exposition corresponds to advanced undergraduate courses of mathematical analysis and first graduate introduction to the discipline. The book contains a large number of problems and exercises, making it suitable for both classroom use and self-study. Many standard exercises are included in each section to develop basic skills and test the understanding of concepts. Other problems are more theoretically oriented and illustrate intricate points of the theory. Many additional problems are proposed as homework tasks whose level ranges from straightforward, but not overly simple, exercises to problems of considerable difficulty but of comparable interest.
The second edition of Yiddish: A Survey and a Grammar makes this classic text available again to students, teachers, and Yiddish-speakers alike.
This book presents a review of the existing literature on natural mycotoxins to create a comprehensive reference for mycotoxin levels. Each entry includes contamination, concentration rate, mostly mean mycotoxin concentration of organs (human and animal) and country of origin of the sample. Due to the serious spoilage and health issues the presence of mycotoxins can cause, it is imperative that corresponding scientists, health institutions and the food and feed industries have a more qualified understanding of mycotoxins in living things. To this end, Natural Mycotoxin Contamination in Humans and Animals provides an excellent resource. The present book complements the series of the author’s previous books, Mycotoxins in Feedstuffs and Mycotoxins in Foodstuffs, in that it is a review of the literature to create a comprehensive reference for mycotoxin levels. As with Mycotoxins and their Metabolites in Humans and Animals, the focus remains the same, but the scope now covers natural mycotoxins only. Comprehensive reference of natural mycotoxin levels in humans and animals Easy-to-use database of mycotoxins Each entry is comprehensive
Improve Failure Detection and Optimize Protection In the ever-evolving field of protective relay technology, an engineer’s personal preference and professional judgment are as important to power system protection as the physical relays used to detect and isolate abnormal conditions. Invaluable Insights from an Experienced Expert Protective Relay Principles focuses on probable power system failure modes and the important characteristics of the protective relays used to detect these postulated failures. The book presents useful new concepts in a way that is easier to understand because they are equally relevant to older, electromechanical and solid-state relays, and newer, more versatile microprocessor-based relays. It introduces the applications, considerations, and setting philosophies used in transmission-line, distribution-line, and substation applications, covering concepts associated with general system operations and fault detection. Topics include relay load limits, cold load pickup, voltage recovery, and arc flash. The author also delves into the philosophies that engineers employ in both urban and rural areas, with a detailed consideration of setpoint function. Analysis of Key Concepts That Are Usually Just Glossed Over This versatile text is ideal for new engineers to use as a tutorial before they open the instruction manuals that accompany multi-function microprocessor-based relays. Guiding readers through the transient loading conditions that can result in relay misoperation, the author elaborates on concepts that are not generally discussed, but can be very helpful in specific applications. Readers will come away with an excellent grasp of important design considerations for working with overcurrent, over- and undervoltage, impedance, distance, and differential type relay functions, either individually or in combination. Also useful for students as a textbook, this book includes practical examples for many applications, and offers guidance for more unusual ones.
Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecule OXR antagonists as novel treatments for sleep disorders. Proof of concept studies from Glaxo Smith Kline, Actelion Pharmaceuticals Ltd. and Merck have now consistently demonstrated the efficacy of dual OXR antagonists (DORAs) in promoting sleep in rodents, dogs, non-human primates and humans. Some of these antagonists have completed late stage clinical testing in primary insomnia. Orexin drug discovery programs have also been initiated by other large pharmaceutical companies including Hoffmann La Roche, Novartis, Eli Lilly and Johnson & Johnson. Orexins are increasingly recognized for orchestrating the activity of the organism’s arousal system with appetite, reward and stress processing pathways. Therefore, in addition to models of insomnia, pharmacological effects of DORAs have begun to be investigated in rodent models of addiction, depression and anxiety. The first clinical trials in diabetic neuropathy, migraine and depression have been initiated with Merck’s MK-6096 (www.clinicaltrials.gov). Whereas the pharmacology of DORAs is established for their effects on wakefulness, pharmacological effects of selective OXR-1 or OXR-2 antagonists (SORAs) have remained less clear. From an evolutionary point of view, the OXR-2 was expressed first in most vertebrate lineages, whereas the OXR-1 is believed to result from a gene duplication event, when mammals emerged. Yet, both receptors do not have redundant function. Their brain expression pattern, their intracellular signaling, as well as their affinity for orexin-A and orexin-B differs. During the past decade most preclinical research on selective OXR-1 antagonism was performed with SB-334867. Only in recent years, other selective OXR-1 and OXR-2 antagonists with optimized selectivity profiles and pharmacokinetic properties have been discovered, and phenotypes of OXR-1 and OXR-2 knockout mice were described. The present Research Topic (referred to in the Editorial as “special topics issue”) comprises submissions of original research manuscripts as well as reviews, directed towards the neuropharmacology of OXR antagonists. The submissions are preclinical papers dealing with dual and/or selective OXR antagonists that shed light on the differential contribution of endogenous orexin signaling through both OXRs for cellular, physiological and behavioral processes. Some manuscripts also report on convergence or divergence of DORA vs. SORA effects with phenotypes expressed by OXR-1 or OXR-2 knockout animals. Ultimately these findings may help further define the potential of DORAs and SORAs in particular therapeutic areas in insomnia and beyond insomnia.
This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
MMIX is a RISC computer designed by Don Knuth to illustrate machine-level aspects of programming. In the author's book series "The Art of Computer Programming", MMIX replaces the 1960s-style machine MIX. A particular goal in the design of MMIX was to keep its machine language simple, elegant, and easy to learn. At the same time, all of the complexities needed to achieve high performance in practice are taken into account. This book constitutes a collection of programs written in CWEB that make MMIX a virtual reality. Among other utilities, an assembler converting MMIX symbolic files to MMIX objects and two simulators executing the programs in given object files are provided. The latest version of all programs can be downloaded from MMIX's home page. The book provides a complete documentation of the MMIX computer and its assembly language. It also presents mini-indexes, which make the programs much easier to understand. A corrected reprint of the book has been published in August 2014, replacing the version of 1999.