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This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.
The role of trace metals, especially copper and zinc, in the pathogenesis of rheumatic conditions has continued to receive much interest following the initial upsurge of research activity in the 1970s. Meantime also copper and zinc complexes receive continued attention for their potential anti-inflam matory actions. Since the previous major titles were published in this field some years ago (e. g. 1,2) it was considered timely to consider progress which has been made in the interceding period. Thus in this volume aspects are re viewed of the metabolism and biodisposition of copper and zinc, especially as they may be influenced by inflammatory processes, the mode of action of copper and zinc compounds in inflammatory states, and the actions of some newer copper complexes. While we still understand relatively little about how copper and zinc complexes work in inflammation, and indeed what the fate of the ligands and their complexed ions is in inflammation, it is hoped that this volume will be useful for giving a current view of the "state of art" in the field. Special thanks are given to the valued efforts of the contributors, Dr Peter Clarke (Publishing Director, Kluwer Academic Publishers) and Mrs Veronica Rainsford-Koechli for her help in proof-reading the manuscripts. K D Rainsford Hamilton, Ontario, Canada February 1989 References 1. Rainsford, K. D. , Brune, K. and Whitehouse, M. W. (eds) (1981). Elements in the pathogenesis a treatment of inflammation.
Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varies at different stages of these diseases and with differing types of conditions. The corollary to this situation is the possibility of using drugs or metal complexes to modify both the perturbed status of copper and zinc and thus the disease states. This book comprehensively reviews the clinical and experimental data on the changes in copper and zinc status in different diseases and the use of various complexes of these metals or drugs to treat a diversity of inflammatory and degenerative conditions.
Zinc: Early Development, Applications, and Emerging Trends is a comprehensive book covering various aspects of the metallic element zinc that has a significant role in the growth and survival of humans. The United Nations Organization has aptly declared it as a ‘Life-Saving Material’ since it helps in overcoming infections and strengthening the immune system. Zinc is an essential element next to iron, aluminum, and copper with abundant presence in nature, and is worth billions of dollars commercially. Besides the metal, its compounds and nanoparticles have also become attractive to researchers due to their enormous applications. The industrial and agricultural uses of the metal and its compounds are widespread. An exclusive book covering all important aspects of zinc is yet to hit the market. This book, with contributions from experts in geology, chemistry, medicine (including dentistry and traditional systems), agriculture, veterinary science, biology, bioinformatics, and nanotechnology encompassing the latest developments in their fields related to zinc, fills this void. The uniqueness of the book is its interdisciplinary nature and potential use by researchers, students, and teachers of various specialties. Features: Contributes to a better understanding of the complexities of zinc’s role in various branches of science Contains basic and practical information for a wider audience and researchers of different fields besides those interested in zinc Provides detailed information on the usefulness of zinc in prophylaxis and treatment of diseases in modern medicine, dentistry, and traditional systems such as Ayurveda, Siddha, and Unani, as well as veterinary medicine Highlights zinc’s role in agriculture and food science with various crops and nutritive materials Includes chapters on fast-growing areas – nanotechnology and bioinformatics
Proceedings of the International Symposium on `Zinc in Soils and Plants', held at The University of Western Australia, Perth, Western Australia, 27--28 September 1993