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Zeta wished to study for her Doctoral Degree at Manchester University. With a heavy heart Giovanni realised the time had come to let his precious daughter achieve her dreams. The Mafia princess aware of her strong family connections was about to face more than she bargained for. Love was a powerful force in more ways than one and Zeta was about to face reality. A powerful story of love and the force of obsession by a jealous rival. POWERFUL MAFIA ROMANTIC SUSPENSE
Zeta wished to study for her doctoral degree at Manchester university, with a heavy heart Giovanni realised the time had come to let his precious daughter achieve her dreams. The mafia princess: unaware of her strong family connections was about to achieve more than she bargained for. Love was a powerful force in more ways than one and Zeta was about to face reality. A powerful story of love and the force of obsession dealt by a jealous companion.
In many European languages the National Standard Variety is converging with spoken, informal, and socially marked varieties. In Italian this process is giving rise to a new standard variety called Neo-standard Italian, which partly consists of regional features. This book contributes to current research on standardization in Europe by offering a comprehensive overview of the re-standardization dynamics in Italian. Each chapter investigates a specific dynamic shaping the emergence of Neo-standard Italian and Regional Standard Varieties, such as the acceptance of previously non-standard features, the reception of Old Italian features excluded from the standard variety, the changing standard language ideology, the retention of features from Italo-Romance dialects, the standardization of patterns borrowed from English, and the developmental tendencies of standard Italian in Switzerland. The contributions investigate phonetic/phonological, prosodic, morphosyntactic, and lexical phenomena, addressed by several empirical methodologies and theoretical vantage points. This work is of interest to scholars and students working on language variation and change, especially those focusing on standard languages and standardization dynamics.
Zeta wished to study for her doctoral degree at Manchester university, with a heavy heart Giovanni realised the time had come to let his precious daughter achieve her dreams. The mafia princess: unaware of her strong family connections was about to achieve more than she bargained for. Love was a powerful force in more ways than one and Zeta was about to face reality. A powerful story of love and the force of obsession.dealt by a jealous rival.
Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and The cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epsteinndash;Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers.
This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.