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This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.
History of Analytical Chemistry is a systematic account of the historical development of analytical chemistry spanning about 4,000 years. Many scientists who have helped to develop the methods of analytical chemistry are mentioned. Various methods of analysis are discussed, including electrogravimetry, optical methods, electrometric analysis, radiochemical analysis, and chromatography. This volume is comprised of 14 chapters and begins with an overview of analytical chemistry in ancient Greece, the origin of chemistry, and the earliest knowledge of analysis. The next chapter focuses on analytical chemistry during the Middle Ages, with emphasis on alchemy. Analytical knowledge during the period of iatrochemistry and the development of analytical chemistry during the phlogiston period are then examined. Subsequent chapters deal with the development of the fundamental laws of chemistry, including the principle of the indestructibility of matter; analytical chemistry during the period of Berzelius; and developments in qualitative and gravimetric analysis. Elementary organic analysis is also considered, along with the development of the theory of analytical chemistry. This book will be helpful to chemists as well as students and researchers in the field of analytical chemistry.
Vols. for 1975- include publications cataloged by the Research Libraries of the New York Public Library with additional entries from the Library of Congress MARC tapes.
Each chapter of Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences have been carefully selected by the editors in order to represent a state-of-the-art overview of how phosphorus chemistry can provide solutions in various fields of applications. The editors have assembled an international array of world-renowned scientists and each chapter is written by experts in the fields of synthetic chemistry, homogeneous catalysis, dendrimers, theoretical calculations, materials science, and medicinal chemistry with a special focus on the chemistry of phosphorus compounds. Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences is of interest to a general readership ranging from advanced university course students to experts in academia and industry.