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Short presentation of aspects important for the application of X-ray contrast media: Composition and properties of contrast media, handling with respect to stability, purity and sterility; applications, interaction, risks; drugs for prophylaxis and treatment of side effects.
Journalists, always very direct and in search of sensation, essentially asked me two questions on the occasion of this workshop: What were the goals of the meeting? With the improvement of diagnosis through the development of image techniques, didn't the contrast media already have their future behind them? Many answers were provided during the course of the workshop, and in order to best answer the journalists I proposed the following synopsis. 1. Since the 1979 Colorado Springs workshop organized by E. Lasser, progress has been so rapid and the newly available works so numerous that another meeting on an international level for the purpose of pre senting and discussing these advances appeared indispensable. Why not then in Europe and why not in Lyon? To expand on this progress, by 1981 the new contrast media with less-hyperosmolar molecules, still in the trial stage in 1979, were al most all available commercially for angiography, albeit at prohibitive prices. The advantages of these various media are becoming better known; moreover, in the wake of Lasser's work, our understanding of the pathophysiology of their noxious effects is also advancing rapidly owing to the use of models (for the target organs: heart, vessel wall, nervous system, kidney; and for the more general reactions: blood cells, coagulation, complement system, circulating enzymatic systems). In addition, further new molecules are currently being studied in re search laboratories. 2.
This volume highlights and broadens our understanding of the correct use and the possible contraindications of contrast agents applied in radiology. Written by experts in the field, it not only focuses on the chemistry, physiochemical properties and pharmacokinetics of both iodinated and gadolinium-containing contrast agents, but also on the relevant safety issues such as frequency of their short- and long-term side effects and ways to avoid them nephrotoxicity risk related to the iodinated contrast agents NSF (nephrogenic systemic fibrosis) accumulation of gadolinium in the brain use of contrast agents in pediatric patients and pregnancy It also includes essential data on the use of contrast agents, such as scanning protocols, in the context of various clinical conditions. This comprehensive manual addresses all professionals involved in radiological imaging and is an invaluable tool for radiologists and technologists, as well as for residents and clinicians.
A fully integrated view of the medical and surgical aspects of both vascular and cardiovascular disease. Covering the complete spectrum of angiology, from basic physiologic principles to phlebology, this is the only text of its kind, and will thus be a must for the libraries of cardiologists and cardiovascular surgeons alike.
This book documents the fascinating history of radiological techniques that use contrast agents. The text includes many of the fundamental documentary sources that bring to life the social and scientific background of the discoveries, the personalities of the discoverers, and implementation of new technologies. Such agents when used with X-rays allow clinicians to distinguish anatomical structures with nearly identical densities. Focus is on urological and angiographic uses of contrast agents. Key selling features: Documents and thoroughly references the history of contrast agent development Reviews the priority and importance of patents Discusses the role that important individual scientists and leading research institutions have played in technology development and implementation
This open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspects of X-ray contrast media. The overall goal of this book is to provide a comprehensive overview relevant for the optimal use of x-ray contrast media covering next to the historic development, their structure and properties also practical information for handling of contrast media, and explanation of the relevant risks during use and measures for prevention and treatment of potential side effects.
This revised edition of Contrast Media: Safety Issues and Guidelines, updates the successful first edition and contains new chapters. It provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media.
For all that new non-X-ray technologies such as MR and ultrasound and its various manifestations have made an enormous impact in recent years on the practice of medical imaging, the use of X-rays and X-ray contrast-enhancing agents has retained an important position at the heart of the process. Indeed, with its frequent requirements for high total dose regimes, CT has increased the use of contrast agents. Even helical/spiral CT which, it was initially argued, should reduce contrast as well as radiation loads, may actually require just as much or more of both because of the potential it offers for multi-phase scanning. Iodinated intravascular X-ray contrast agents, especially the more recently developed non-ionic agents, continue therefore to play a pivotal role in clinical imaging. These succinct and authoritative articles, originally appearing in the journal Advances in X-ray Contrast, range sufficiently widely for their compilation in this volume to be considered a mini-textbook on the water-soluble iodinated X-ray contrast agents and their applications. Each is written by an acknowledged and experienced expert in the field. They usefully cover the developmental history of the agents; defined risk factors, approaches to prophylaxis and, ultimately, of the treatment of adverse reactions; the interesting subject of supposed delayed reactions to contrast agents; the important organ-specific toxicities, cardiac toxicity, neurotoxicity and nephrotoxicity and high-dose toxicity as encountered in complex procedures; the sometimes special circumstances and occasional extreme conditions to which contrast agents may be exposed in Interventional Radiology; the special, in several ways, case of paediatric radiology; the controversial subject of thromboembolic phenomena in clinical angiography; and the precise role of contrast agents. As regards the practicalities of contrast administration regimes and imaging protocols it is really only in the area of CT that there is debate and controversy, and articles are included which cover CT of the liver, spleen and pancreas, and protocols for the new spiral/helical technology and even for the much less widely available electron-beam CT technology visualization. Pulmonary embolus diagnosis and protocols for contrast administration with this technology are also discussed.
This book is the first to cover the field of contrast media from basic sciences through to clinical practice. Textbook of Contrast Media provides the first exhaustive account of the use of contrast media in clinical practice. Edited by distinguished figures in the field, the book is divided into five main sections: history and background, X-ray contrast agents, MR contrast agents, ultrasound contrast agents, and future developments. Each chapter is fully referenced and benefits from the exensive use of high quality radiographs and illustrations.
This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.